RegulonDB RegulonDB 11.1: Gene Form
   

hybB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hybC hybB hybO hybA hybD hybE TSS_3309 (cluster) TSS_3309 (cluster) TSS_3308 TSS_3308 TSS_3307 TSS_3307 TSS_3306 TSS_3306

Gene      
Name: hybB    Texpresso search in the literature
Synonym(s): ECK2989, EG11800, b2995
Genome position(nucleotides): 3142986 <-- 3144164
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.11
External database links:  
ASAP:
 ABE-0009830
CGSC:
 33414
ECHOBASE:
 EB1748
ECOLIHUB:
 hybB
OU-MICROARRAY:
 b2995
STRING:
 511145.b2995
COLOMBOS: hybB


Product      
Name: hydrogenase 2 membrane subunit
Synonym(s): HybB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 43.602
Isoelectric point: 9.033
Motif(s):
 
Type Positions Sequence Comment
12 -> 32 IISKPVMIFGPLIVICMLLIV UniProt: Helical.
35 -> 55 LVFGLGSVSDLNGGFPWGVWI UniProt: Helical.
45 -> 330 LNGGFPWGVWIAFDLLIGTGFACGGWALAWAVYVFNRGQYHPLVRPALLASLFGYSLGGLSITIDVGRYWNLPYFYIPGHFNVNSVLFETAVCMTIYIGVMALEFAPALFERLGWKVSLQRLNKVMFFIIALGALLPTMHQSSMGSLMISAGYKVHPLWQSYEMLPLFSLLTAFIMGFSIVIFEGSLVQAGLRGNGPDEKSLFVKLTNTISVLLAIFIVLRFGELIYRDKLSLAFAGDFYSVMFWIEVLLMLFPLVVLRVAKLRNDSRMLFLSALSALLGCATWRL
59 -> 79 LLIGTGFACGGWALAWAVYVF UniProt: Helical.
91 -> 111 ALLASLFGYSLGGLSITIDVG UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.7 - anaerobic respiration
  1 - metabolism --> 1.4 - energy production/transport --> 1.4.1 - electron donors
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.15 - large molecule carriers --> 1.6.15.1 - cytochromes
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0009326 - formate dehydrogenase complex
GO:0044569 - [Ni-Fe] hydrogenase complex
molecular_function GO:0046872 - metal ion binding
GO:0033748 - hydrogenase (acceptor) activity
GO:0036397 - formate dehydrogenase (quinone) activity
biological_process GO:0009061 - anaerobic respiration
GO:0019645 - anaerobic electron transport chain
GO:0015944 - formate oxidation
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P37180
ECOCYC:
 EG11800-MONOMER
ECOLIWIKI:
 b2995
INTERPRO:
 IPR005614
PFAM:
 PF03916
PRIDE:
 P37180
REFSEQ:
 NP_417469
UNIPROT:
 P37180


Operon      
Name: hybOABCDEFG         
Operon arrangement:
Transcription unit        Promoter
hybOABCDEFG


Transcriptional Regulation      
Display Regulation             
Repressed by: NarL, ArcA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3306 3141794 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3307 3144533 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3308 3145033 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3309 (cluster) 3145041 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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