RegulonDB

RegulonDB RegulonDB 10.8: Gene Form

tehA gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	tehA
Synonym(s):	ECK1422, EG11883, b1429
Genome position(nucleotides):	1500573 --> 1501565 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.17
External database links:

ASAP:	ABE-0004770
CGSC:	32106
ECHOBASE:	EB1829
OU-MICROARRAY:	b1429
PortEco:	tehA
STRING:	511145.b1429
COLOMBOS:	tehA

Product

Name:

tellurite resistance protein

Synonym(s):

TehA

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

35.932

Isoelectric point:

8.814

Motif(s):

Type	Positions	Sequence
	162 -> 189	TDAGLVFLGAGVFSWLSLEPVILQRLRS
	80 -> 98	SSFVSLFPATTMLVAIGFV
	195 -> 218	TALRTSLGIQLAPALVACSAWLSV
	255 -> 275	ASFWSFSFGVSALATTGLHLG
	8 -> 28	NLPAGYFGIVLGTIGMGFAWR

Classification:

Multifun Terms (GenProtEC)
		4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
		5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
		6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane
	molecular_function	GO:0046583 - cation efflux transmembrane transporter activity GO:0042802 - identical protein binding
	biological_process	GO:0006811 - ion transport GO:0006812 - cation transport GO:0046677 - response to antibiotic GO:0046690 - response to tellurium ion GO:0055085 - transmembrane transport GO:0098655 - cation transmembrane transport

Note(s):

Note(s): ...[more].

Reference(s):

[1] Jindal S., et al., 2019

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

tehAB

Operon arrangement:

Transcription unit	Promoter
tehAB	tehAp

Transcriptional Regulation
	Display Regulation
Repressed by:	NsrR

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	ydcKp8	1500640	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 4.846. P-value: 4.276e-5 Read more >	[ICWHO]	[2]
promoter	TSS_1809	1501349	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_1810	1501486	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_1811	1501538	forward	nd	[RS-EPT-CBR]	[3]
promoter	ydcLp7	1502323	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 6.095. P-value: 3.792e-5 Read more >	[ICWHO]	[2]
promoter	ydcLp4	1502345	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.54. P-value: 4.233e-5 Read more >	[ICWHO]	[2]
promoter	ydcLp1	1502369	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: 2.814. P-value: 6.252e-5 Read more >	[ICWHO]	[2]
promoter	ydcLp6	1502445	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.89. P-value: 1.441e-6 Read more >	[ICWHO]	[2]
promoter	ydcLp5	1502446	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.286. P-value: 9.611e-5 Read more >	[ICWHO]	[2]

Evidence
[ICWHO] Inferred computationally without human oversight
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195
[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
[3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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