RegulonDB RegulonDB 10.8: Gene Form
   

tehA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

tehA ydcK ydcL tehB rimL NsrR NsrR terminator anti-terminator anti-anti-terminator terminator ydcLp5 ydcLp5 ydcLp6 ydcLp6 ydcLp1 ydcLp1 ydcLp4 ydcLp4 ydcLp7 ydcLp7 TSS_1811 TSS_1811 TSS_1810 TSS_1810 TSS_1809 TSS_1809 ydcKp8 ydcKp8 tehAp tehAp

Gene      
Name: tehA    Texpresso search in the literature
Synonym(s): ECK1422, EG11883, b1429
Genome position(nucleotides): 1500573 --> 1501565 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
53.17
External database links:  
ASAP:
ABE-0004770
CGSC:
32106
ECHOBASE:
EB1829
OU-MICROARRAY:
b1429
PortEco:
tehA
STRING:
511145.b1429
COLOMBOS: tehA


Product      
Name: tellurite resistance protein
Synonym(s): TehA
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 35.932
Isoelectric point: 8.814
Motif(s):
 
Type Positions Sequence
162 -> 189 TDAGLVFLGAGVFSWLSLEPVILQRLRS
80 -> 98 SSFVSLFPATTMLVAIGFV
195 -> 218 TALRTSLGIQLAPALVACSAWLSV
255 -> 275 ASFWSFSFGVSALATTGLHLG
8 -> 28 NLPAGYFGIVLGTIGMGFAWR

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0046583 - cation efflux transmembrane transporter activity
GO:0042802 - identical protein binding
biological_process GO:0006811 - ion transport
GO:0006812 - cation transport
GO:0046677 - response to antibiotic
GO:0046690 - response to tellurium ion
GO:0055085 - transmembrane transport
GO:0098655 - cation transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
External database links:  
DIP:
DIP-10977N
ECOCYC:
TEHA-MONOMER
ECOLIWIKI:
b1429
INTERPRO:
IPR038665
INTERPRO:
IPR011552
INTERPRO:
IPR004695
INTERPRO:
IPR039264
PFAM:
PF03595
PRIDE:
P25396
PRODB:
PRO_000024046
REFSEQ:
NP_415946
SMR:
P25396
UNIPROT:
P25396


Operon      
Name: tehAB         
Operon arrangement:
Transcription unit        Promoter
tehAB


Transcriptional Regulation      
Display Regulation             
Repressed by: NsrR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter ydcKp8 1500640 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_1809 1501349 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1810 1501486 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1811 1501538 forward nd [RS-EPT-CBR] [3]
  promoter ydcLp7 1502323 forward Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter ydcLp4 1502345 forward Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter ydcLp1 1502369 forward Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter ydcLp6 1502445 forward Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter ydcLp5 1502446 forward Similarity to the consensus
Read more >
[ICWHO] [2]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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