RegulonDB RegulonDB 10.9: Gene Form
   

lldP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

lldP lldD lldR yibL LldR ArcA ArcA LldR lldPp lldPp

Gene      
Name: lldP    Texpresso search in the literature
Synonym(s): ECK3593, EG11961, b3603, lct, lctP
Genome position(nucleotides): 3777399 --> 3779054 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
55.13
Reference(s): [1] Erwin AL., et al., 1996
External database links:  
ASAP:
ABE-0011777
CGSC:
35161
ECHOBASE:
EB1904
ECOLIHUB:
lldP
ECOO157CYC:
LLDP
OU-MICROARRAY:
b3603
STRING:
511145.b3603
COLOMBOS: lldP


Shine dalgarno      
Sequence: cgtggactccAGGAGAcctgcaATG


Product      
Name: lactate/glycolate:H+ symporter LldP
Synonym(s): Lct, LctP, LldP
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 59.168
Isoelectric point: 9.019
Motif(s):
 
Type Positions Sequence
37 -> 57 LKGYVAASWTVAIALAVALLF
16 -> 542 LSSLIASLPILFFFFALIKLKLKGYVAASWTVAIALAVALLFYKMPVANALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFCFGAFLEGAAGFGAPVAITAALLVGLGFKPLYAAGLCLIVNTAPVAFGAMGIPILVAGQVTGIDSFEIGQMVGRQLPFMTIIVLFWIMAIMDGWRGIKETWPAVVVAGGSFAIAQYLSSNFIGPELPDIISSLVSLLCLTLFLKRWQPVRVFRFGDLGASQVDMTLAHTGYTAGQVLRAWTPFLFLTATVTLWSIPPFKALFASGGALYEWVINIPVPYLDKLVARMPPVVSEATAYAAVFKFDWFSATGTAILFAALLSIVWLKMKPSDAISTFGSTLKELALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFTFFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGVSDLLLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFTVKHSLIFTCIVGVITTLQ
159 -> 179 LCLIVNTAPVAFGAMGIPILV
13 -> 33 NIWLSSLIASLPILFFFFALI
70 -> 90 VYGFFYGLWPIAWIIIAAVFV

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015295 - solute:proton symporter activity
GO:0015129 - lactate transmembrane transporter activity
GO:0043879 - glycolate transmembrane transporter activity
biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0015727 - lactate transport
GO:0035873 - lactate transmembrane transport
GO:1902600 - proton transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-10109N
ECOCYC:
LCTP-MONOMER
ECOLIWIKI:
b3603
INTERPRO:
IPR003804
PANTHER:
PTHR30003
PFAM:
PF02652
PRIDE:
P33231
PRODB:
PRO_000023101
REFSEQ:
NP_418060
UNIPROT:
P33231


Operon      
Name: lldPRD         
Operon arrangement:
Transcription unit        Promoter
lldPRD


Transcriptional Regulation      
Display Regulation             
Activated by: LldR
Repressed by: LldR, ArcA


Regulation by small RNA    
  Display Regulation
small RNA spf


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Erwin AL., Gotschlich EC., 1996, Cloning of a Neisseria meningitidis gene for L-lactate dehydrogenase (L-LDH): evidence for a second meningococcal L-LDH with different regulation., J Bacteriol 178(16):4807-13


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