RegulonDB RegulonDB 10.10: Gene Form
   

lldR gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

lldP lldD lldR trmL yibL LldR ArcA ArcA LldR terminator anti-terminator lldPp lldPp

Gene      
Name: lldR    Texpresso search in the literature
Synonym(s): ECK3594, EG11962, b3604, lct, lctR
Genome position(nucleotides): 3779054 --> 3779830 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.05
Reference(s): [1] Erwin AL., et al., 1996
External database links:  
ASAP:
 ABE-0011782
CGSC:
 35164
ECHOBASE:
 EB1905
ECOLIHUB:
 lldR
ECOO157CYC:
 LLDR
OU-MICROARRAY:
 b3604
STRING:
 511145.b3604
COLOMBOS: lldR


Shine dalgarno      
Sequence: tgtcttaacgTGGATGattccttaATG


Product      
Name: DNA-binding transcriptional dual regulator LldR
Synonym(s): Lct, LctR, LldR
Sequence: Get amino acid sequence Fasta Format
Regulator Family: GntR
Cellular location: cytosol
Molecular weight: 29.166
Isoelectric point: 6.927
Motif(s):
 
Type Positions Sequence
8 -> 71 LSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI
34 -> 53 ERQLAMQLGVSRNSLREALA
6 -> 74 RRLSDEVADRVRALIDEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWR
100 -> 222 DILEARYAIEASTAWHAAMRATPGDKEKIQLCFEATLSEDPDIASQADVRFHLAIAEASHNIVLLQTMRGFFDVLQSSVKHSRQRMYLVPPVFSQLTEQHQAVIDAIFAGDADGARKAMMAHL

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.6 - aerobic respiration
  2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
  3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0000986 - bacterial-type cis-regulatory region sequence-specific DNA binding
GO:0001217 - DNA-binding transcription repressor activity
GO:0001216 - DNA-binding transcription activator activity
biological_process GO:0006355 - regulation of transcription, DNA-templated
GO:0006974 - cellular response to DNA damage stimulus
GO:0044010 - single-species biofilm formation
GO:2000143 - negative regulation of DNA-templated transcription, initiation
GO:2000144 - positive regulation of DNA-templated transcription, initiation
Note(s): Note(s): ...[more].
Evidence: [IDA] Inferred from direct assay
Reference(s): [2] Aguilera L., et al., 2008
External database links:  
DIP:
 DIP-10110N
ECOCYC:
 EG11962-MONOMER
ECOLIWIKI:
 b3604
ECOO157CYC:
 LLDR-MONOMER
INTERPRO:
 IPR011711
INTERPRO:
 IPR008920
INTERPRO:
 IPR000524
INTERPRO:
 IPR036388
INTERPRO:
 IPR036390
MODBASE:
 P0ACL7
PFAM:
 PF00392
PFAM:
 PF07729
PRIDE:
 P0ACL7
PRINTS:
 PR00035
PROSITE:
 PS50949
REFSEQ:
 NP_418061
SMART:
 SM00345
SMART:
 SM00895
SMR:
 P0ACL7
UNIPROT:
 P0ACL7


Operon      
Name: lldPRD         
Operon arrangement:
Transcription unit        Promoter
lldPRD


Transcriptional Regulation      
Display Regulation             
Activated by: LldR
Repressed by: LldR, ArcA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Erwin AL., Gotschlich EC., 1996, Cloning of a Neisseria meningitidis gene for L-lactate dehydrogenase (L-LDH): evidence for a second meningococcal L-LDH with different regulation., J Bacteriol 178(16):4807-13

 [2] Aguilera L., Campos E., Gimenez R., Badia J., Aguilar J., Baldoma L., 2008, Dual role of LldR in regulation of the lldPRD operon, involved in L-lactate metabolism in Escherichia coli., J Bacteriol 190(8):2997-3005

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