RegulonDB RegulonDB 10.8: Gene Form
   

ccmA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ccmC ccmB ccmA napC ccmD

Gene      
Name: ccmA    Texpresso search in the literature
Synonym(s): ECK2193, EG12059, b2201, yejW
Genome position(nucleotides): 2297021 <-- 2297644 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
55.93
External database links:  
ASAP:
ABE-0007279
CGSC:
36574
ECHOBASE:
EB1989
OU-MICROARRAY:
b2201
PortEco:
ccmA
STRING:
511145.b2201
COLOMBOS: ccmA


Product      
Name: heme trafficking system ATP-binding protein
Synonym(s): CcmA, YejW
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol,inner membrane
Molecular weight: 23.053
Isoelectric point: 7.22
Motif(s):
 
Type Positions Sequence
42 -> 42 K
129 -> 133 LSAGQ
132 -> 132 G
36 -> 43 GSNGAGKT
4 -> 207 LEARELLCERDERTLFSGLSFTLNAGEWVQITGSNGAGKTTLLRLLTGLSRPDAGEVLWQGQPLHQVRDSYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGLAGFEDIPVNQLSAGQQRRVALARLWLTRATLWILDEPFTAIDVNGVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRAA

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.12 - heme, porphyrine
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.15 - large molecule carriers --> 1.6.15.1 - cytochromes
  2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.a - ABC superfamily ATP binding cytoplasmic component
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
molecular_function GO:0005515 - protein binding
GO:0016887 - ATPase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0015439 - ATPase-coupled heme transmembrane transporter activity
GO:0022857 - transmembrane transporter activity
biological_process GO:0035351 - heme transmembrane transport
GO:0017004 - cytochrome complex assembly
GO:0015886 - heme transport
GO:0055085 - transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
[2] Schulz H., et al., 1999
External database links:  
ECOCYC:
CCMA-MONOMER
ECOLIWIKI:
b2201
INTERPRO:
IPR005895
INTERPRO:
IPR027417
INTERPRO:
IPR017871
INTERPRO:
IPR003593
INTERPRO:
IPR003439
MODBASE:
P33931
PANTHER:
PTHR43499
PFAM:
PF00005
PRIDE:
P33931
PRODB:
PRO_000022257
PROSITE:
PS00211
PROSITE:
PS51243
PROSITE:
PS50893
REFSEQ:
NP_416705
SMART:
SM00382
SMR:
P33931
UNIPROT:
P33931


Operon      
Name: napFDAGHBC-ccmABCDEFGH         
Operon arrangement:
Transcription unit        Promoter
napFDAGHBC-ccmABCDEFGH
napFDAGHBC-ccmABCDEFGH
napFDAGHBC
ccmABCDEFGH


Transcriptional Regulation      
Display Regulation             
Activated by: FNR, NarP, FlhDC, ModE
Repressed by: NarL, NarP


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Schulz H., Fabianek RA., Pellicioli EC., Hennecke H., Thony-Meyer L., 1999, Heme transfer to the heme chaperone CcmE during cytochrome c maturation requires the CcmC protein, which may function independently of the ABC-transporter CcmAB., Proc Natl Acad Sci U S A 96(11):6462-7


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