RegulonDB RegulonDB 11.1: Gene Form
   

nuoN gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

Gene      
Name: nuoN    Texpresso search in the literature
Synonym(s): ECK2270, EG12093, b2276
Genome position(nucleotides): 2390048 <-- 2391505
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
57.2
External database links:  
ASAP:
ABE-0007526
CGSC:
29354
ECHOBASE:
EB2017
ECOLIHUB:
nuoN
OU-MICROARRAY:
b2276
STRING:
511145.b2276
COLOMBOS: nuoN


Product      
Name: NADH:quinone oxidoreductase subunit N
Synonym(s): NADH:ubiquinone oxidoreductase, membrane subunit N, NuoN
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 52.044
Isoelectric point: 8.697
Motif(s):
 
Type Positions Sequence Comment
1 -> 1 M UniProt: Shows 20% of the wild-type rate of deamino-NADH oxidase..
8 -> 28 LIALLPLLIVGLTVVVVMLSI UniProt: Helical.
35 -> 55 FLNATLSVIGLNAALVSLWFV UniProt: Helical.
71 -> 91 GFAMLYTGLVLLASLATCTFA UniProt: Helical.
105 -> 125 FYLLVLIAALGGILLANANHL UniProt: Helical.

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.6 - aerobic respiration
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.7 - anaerobic respiration
  1 - metabolism --> 1.4 - energy production/transport --> 1.4.1 - electron donors
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.D - Oxidoreduction-driven Active Transporters
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0030964 - NADH dehydrogenase complex
GO:0045271 - respiratory chain complex I
GO:0045272 - plasma membrane respiratory chain complex I
molecular_function GO:0003954 - NADH dehydrogenase activity
GO:0008137 - NADH dehydrogenase (ubiquinone) activity
GO:0050136 - NADH dehydrogenase (quinone) activity
GO:0048038 - quinone binding
biological_process GO:0009060 - aerobic respiration
GO:0015990 - electron transport coupled proton transport
GO:0042773 - ATP synthesis coupled electron transport
GO:0022904 - respiratory electron transport chain
Note(s): Note(s): ...[more].
Reference(s): [1] Gustavsson T., et al., 2010
External database links:  
ALPHAFOLD:
P0AFF0
DIP:
DIP-59256N
ECOCYC:
NUON-MONOMER
ECOLIWIKI:
b2276
INTERPRO:
IPR001750
INTERPRO:
IPR010096
PFAM:
PF00361
PRIDE:
P0AFF0
PRODB:
PRO_000023441
REFSEQ:
NP_416779
SMR:
P0AFF0
UNIPROT:
P0AFF0


Operon      
Name: nuoABCEFGHIJKLMN         
Operon arrangement:
Transcription unit        Promoter
nuoABCEFGHIJKLMN
nuoABCEFGHIJKLMN
nuoMN


Transcriptional Regulation      
Display Regulation             
Activated by: NarL, Fis
Repressed by: FNR, IHF, ArcA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2530 2390949 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2531 2391121 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2532 2391223 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2533 2391462 forward nd [RS-EPT-CBR] [2]
  promoter nuoNp1 2391717 reverse nd [COMP-AINF] [3]



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