RegulonDB RegulonDB 10.6.3: Gene Form
   

mdtF gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mdtF mdtE gadW

Gene      
Name: mdtF    Texpresso search in the literature
Synonym(s): ECK3498, EG12241, b3514, yhiV
Genome position(nucleotides): 3660414 --> 3663527 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
53.02
External database links:  
ASAP:
ABE-0011480
ECHOBASE:
EB2152
ECOCYC:
EG12241
ECOLIHUB:
mdtF
OU-MICROARRAY:
b3514
REGULONDB:
b3514
STRING:
511145.b3514
M3D: mdtF
COLOMBOS: mdtF
PortEco: b3514


Product      
Name: multidrug efflux pump RND permease MdtF
Synonym(s): MdtF, YhiV
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 111.517
Isoelectric point: 5.105
Motif(s):
 
Type Positions Sequence
392 -> 413 TLTMFGMVLAIGLLVDDAIVVV
537 -> 555 GRYMVVYLLICAGMAVLFL
10 -> 28 VFAWVLAIIMMLAGGLAIM
1005 -> 1027 VMGGMFAATVLAIYFVPVFFVVV
923 -> 944 VYFQVGLLTTIGLSAKNAILIV

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters
  5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015125 - bile acid transmembrane transporter activity
GO:0005215 - transporter activity
GO:0015562 - efflux transmembrane transporter activity
GO:0022857 - transmembrane transporter activity
GO:0015238 - drug transmembrane transporter activity
GO:0042802 - identical protein binding
biological_process GO:1990961 - drug transmembrane export
GO:0009636 - response to toxic substance
GO:0046677 - response to antibiotic
GO:0006855 - drug transmembrane transport
GO:0055085 - transmembrane transport
GO:0015721 - bile acid and bile salt transport
Note(s): Note(s): ...[more].
Reference(s): [1] Shuster Y., et al., 2016
External database links:  
ECOCYC:
YHIV-MONOMER
ECOLIWIKI:
b3514
INTERPRO:
IPR027463
INTERPRO:
IPR004764
INTERPRO:
IPR001036
MODBASE:
P37637
PANTHER:
PTHR32063
PFAM:
PF00873
PRIDE:
P37637
PRINTS:
PR00702
PRODB:
PRO_000023186
PROTEINMODELPORTAL:
P37637
REFSEQ:
NP_417971
SMR:
P37637
SWISSMODEL:
P37637
UNIPROT:
P37637


Operon      
Name: gadEF-mdtEF         
Operon arrangement:
Transcription unit        Promoter
gadE
gadE-mdtEF
gadE
gadEF-mdtEF
null
mdtEF
mdtEF


Transcriptional Regulation      
Display Regulation             
Activated by: EvgA, GadX, GadW, YdeO, GadE
Repressed by: FliZ, CRP, H-NS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Shuster Y., Steiner-Mordoch S., Alon Cudkowicz N., Schuldiner S., 2016, A Transporter Interactome Is Essential for the Acquisition of Antimicrobial Resistance to Antibiotics., PLoS One 11(4):e0152917


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