RegulonDB

RegulonDB RegulonDB 10.9: Gene Form

gntR gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	gntR
Synonym(s):	ECK3423, EG12630, b3438
Genome position(nucleotides):	3577731 <-- 3578726 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	54.42
External database links:

ASAP:	ABE-0011226
CGSC:	667
ECHOBASE:	EB2514
ECOLIHUB:	gntR
OU-MICROARRAY:	b3438
STRING:	511145.b3438
COLOMBOS:	gntR

Shine dalgarno
Sequence:	tttgtaccttCAGGACGAT

Product

Name:

DNA-binding transcriptional repressor GntR

Synonym(s):

GntR

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

GalR/LacI

Cellular location:

cytosol

Molecular weight:

36.422

Isoelectric point:

6.883

Motif(s):

Type	Positions	Sequence
	8 -> 52	LQDVADRVGVTKMTVSRFLRNPEQVSVALRGKIAAALDELGYIPN
	6 -> 60	PVLQDVADRVGVTKMTVSRFLRNPEQVSVALRGKIAAALDELGYIPNRAPDILSN
	64 -> 309	RAIGVLLPSLTNQVFAEVLRGIESVTDAHGYQTMLAHYGYKPEMEQERLESMLSWNIDGLILTERTHTPRTLKMIEVAGIPVVELMDSKSPCLDIAVGFDNFEAARQMTTAIIARGHRHIAYLGARLDERTIIKQKGYEQAMLDAGLVPYSVMVEQSSSYSSGIELIRQARREYPQLDGVFCTNDDLAVGAAFECQRLGLKVPDDMAIAGFHGHDIGQVMEPRLASVLTPRERMGSIGAERLLARI

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
		3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0000976 - transcription regulatory region sequence-specific DNA binding
	biological_process	GO:0006355 - regulation of transcription, DNA-templated GO:0006974 - cellular response to DNA damage stimulus GO:0045892 - negative regulation of transcription, DNA-templated GO:0045893 - positive regulation of transcription, DNA-templated GO:0046177 - D-gluconate catabolic process

Note(s):

Note(s): ...[more].

Evidence:

[IE] Inferred from experiment

Reference(s):

[1] Tong S., et al., 1996
[2] Zwaig N., et al., 1973

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PFAM:

PRIDE:

PRODB:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMR:

UNIPROT:

Operon

Name:

gntRKU

Operon arrangement:

Transcription unit	Promoter
gntK	gntKp
gntKU	gntKp
gntR	gntRp2
gntR	gntRp3
gntR	gntRp4
gntRKU
gntU

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	gntUp2	3577085		reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.825. P-value: 3.363e-5 Read more >	[ICWHO]	[3]
	promoter	gntRp1	3578749		reverse	The gntRp promoter is constitutively expressed. Read more >	[AIPP], [ICWHO]	[3], [4]

Evidence
[ICWHO] Inferred computationally without human oversight
[AIPP] Automated inference of promoter position

Reference(s)
[1] Tong S., Porco A., Isturiz T., Conway T., 1996, Cloning and molecular genetic characterization of the Escherichia coli gntR, gntK, and gntU genes of GntI, the main system for gluconate metabolism., J Bacteriol 178(11):3260-9
[2] Zwaig N., Nagel de Zwaig R., Isturiz T., Wecksler M., 1973, Regulatory mutations affecting the gluconate system in Escherichia coli., J Bacteriol 114(2):469-73
[3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
[4] Izu H., Adachi O., Yamada M., 1997, Gene organization and transcriptional regulation of the gntRKU operon involved in gluconate uptake and catabolism of Escherichia coli., J Mol Biol 267(4):778-93

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