RegulonDB RegulonDB 10.10: Gene Form
   

exuT gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

uxaC exuT exuR ExuR CRP UxuR ExuR ExuR CRP ExuR ExuR CRP ExuR TSS_3391 (cluster) TSS_3391 (cluster) exuRp2 exuRp2 exuRp exuRp exuTp1 exuTp1 exuTp2 exuTp2 uxaCp uxaCp uxaCp1 uxaCp1 TSS_3390 TSS_3390 TSS_3389 TSS_3389

Gene      
Name: exuT    Texpresso search in the literature
Synonym(s): ECK3084, EG12738, b3093
Genome position(nucleotides): 3245224 --> 3246522 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.43
External database links:  
ASAP:
 ABE-0010171
CGSC:
 800
ECHOBASE:
 EB2594
ECOLIHUB:
 exuT
OU-MICROARRAY:
 b3093
STRING:
 511145.b3093
COLOMBOS: exuT


Product      
Name: hexuronate transporter
Synonym(s): ExuT
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 46.892
Isoelectric point: 8.946
Motif(s):
 
Type Positions Sequence
49 -> 69 YIIAAYSAAYTVMQPVAGYVL
100 -> 120 GLAVARGAVGAAEAAMIPAGL
76 -> 96 IGYAMFAVLWAVFCGATALAG
139 -> 159 FNVGSSIGAMIAPPLVVWAIV
328 -> 350 AIMLLCIGGFAHQALSGALITLS

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0022857 - transmembrane transporter activity
GO:0015134 - hexuronate transmembrane transporter activity
biological_process GO:0055085 - transmembrane transport
GO:0015736 - hexuronate transmembrane transport
GO:0015778 - hexuronide transport
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 EXUT-MONOMER
ECOLIWIKI:
 b3093
INTERPRO:
 IPR020846
INTERPRO:
 IPR036259
INTERPRO:
 IPR011701
MODBASE:
 P0AA78
PFAM:
 PF07690
PRIDE:
 P0AA78
PRODB:
 PRO_000022558
PROSITE:
 PS50850
REFSEQ:
 NP_417564
UNIPROT:
 P0AA78


Operon      
Name: exuT         
Operon arrangement:
Transcription unit        Promoter
exuT
exuT


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, DpiA
Repressed by: ExuR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3389 3244779 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3390 3244787 reverse nd [RS-EPT-CBR] [1]
  promoter exuRp 3246508 forward nd [AIPP], [ICWHO] [2], [3]
  promoter TSS_3391 (cluster) 3246624 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [AIPP] Automated inference of promoter position

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Gama-Castro S., Jimenez-Jacinto V., Peralta-Gil M., Santos-Zavaleta A., Penaloza-Spinola MI., Contreras-Moreira B., Segura-Salazar J., Muniz-Rascado L., Martinez-Flores I., Salgado H., Bonavides-Martinez C., Abreu-Goodger C., Rodriguez-Penagos C., Miranda-Rios J., Morett E., Merino E., Huerta AM., Trevino-Quintanilla L., Collado-Vides J., 2008, RegulonDB (version 6.0): gene regulation model of Escherichia coli K-12 beyond transcription, active (experimental) annotated promoters and Textpresso navigation., Nucleic Acids Res 36(Database issue):D120-4

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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