RegulonDB RegulonDB 11.1: Gene Form
   

tynA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

tynA paaZ feaB FeaR FeaR anti-anti-terminator anti-terminator terminator tynAp tynAp

Gene      
Name: tynA    Texpresso search in the literature
Synonym(s): ECK1383, EG13139, b1386, feaA, maoA
Genome position(nucleotides): 1449076 <-- 1451349
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.62
Reference(s): [1] Steinebach V., et al., 1996
External database links:  
ASAP:
 ABE-0004639
CGSC:
 59
ECHOBASE:
 EB2934
ECOLIHUB:
 tynA
OU-MICROARRAY:
 b1386
STRING:
 511145.b1386
COLOMBOS: tynA


Product      
Name: copper-containing amine oxidase
Synonym(s): FeaA, MaoA, TynA
Sequence: Get amino acid sequence Fasta Format
Cellular location: periplasmic space
Molecular weight: 84.379
Isoelectric point: 5.715
Motif(s):
 
Type Positions Sequence Comment
1 -> 30 MGSPSLYSARKTTLALAVALSFAWQAPVFA
31 -> 757 HGGEAHMVPMDKTLKEFGADVQWDDYAQLFTLIKDGAYVKVKPGAQTAIVNGQPLALQVPVVMKDNKAWVSDTFINDVFQSGLDQTFQVEKRPHPLNALTADEIKQAVEIVKASADFKPNTRFTEISLLPPDKEAVWAFALENKPVDQPRKADVIMLDGKHIIEAVVDLQNNKLLSWQPIKDAHGMVLLDDFASVQNIINNSEEFAAAVKKRGITDAKKVITTPLTVGYFDGKDGLKQDARLLKVISYLDVGDGNYWAHPIENLVAVVDLEQKKIVKIEEGPVVPVPMTARPFDGRDRVAPAVKPMQIIEPEGKNYTITGDMIHWRNWDFHLSMNSRVGPMISTVTYNDNGTKRKVMYEGSLGGMIVPYGDPDIGWYFKAYLDSGDYGMGTLTSPIARGKDAPSNAVLLNETIADYTGVPMEIPRAIAVFERYAGPEYKHQEMGQPNVSTERRELVVRWISTVGNYDYIFDWIFHENGTIGIDAGATGIEAVKGVKAKTMHDETAKDDTRYGTLIDHNIVGTTHQHIYNFRLDLDVDGENNSLVAMDPVVKPNTAGGPRTSTMQVNQYNIGNEQDAAQKFDPGTIRLLSNPNKENRMGNPVSYQIIPYAGGTHPVAKGAQFAPDEWIYHRLSFMDKQLWVTRYHPGERFPEGKYPNRSTHDTGLGQYSKDNESLDNTDAVVWMTTGTTHVARAEEWPIMPTEWVHTLLKPWNFFDETPTLGALKKDK UniProt: Primary amine oxidase.
33 -> 33 G UniProt: In Ref. 9; AA sequence..
36 -> 110 HMVPMDKTLKEFGADVQWDDYAQLFTLIKDGAYVKVKPGAQTAIVNGQPLALQVPVVMKDNKAWVSDTFINDVFQ
42 -> 42 K UniProt: In strain: W..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.4 - amines
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.30 - threonine catabolism
Gene Ontology Terms (GO)  
cellular_component GO:0030288 - outer membrane-bounded periplasmic space
GO:0042597 - periplasmic space
molecular_function GO:0005507 - copper ion binding
GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0008131 - primary amine oxidase activity
GO:0005509 - calcium ion binding
GO:0042803 - protein homodimerization activity
GO:0048038 - quinone binding
GO:0052593 - tryptamine:oxygen oxidoreductase (deaminating) activity
GO:0052594 - aminoacetone:oxygen oxidoreductase(deaminating) activity
GO:0052595 - aliphatic-amine oxidase activity
GO:0052596 - phenethylamine:oxygen oxidoreductase (deaminating) activity
biological_process GO:0009308 - amine metabolic process
GO:0019607 - phenylethylamine catabolic process
GO:0006559 - L-phenylalanine catabolic process
External database links:  
ALPHAFOLD:
 P46883
DIP:
 DIP-11057N
ECOCYC:
 AMINEOXID-MONOMER
ECOLIWIKI:
 b1386
INTERPRO:
 IPR012854
INTERPRO:
 IPR036460
INTERPRO:
 IPR000269
INTERPRO:
 IPR036582
INTERPRO:
 IPR015798
INTERPRO:
 IPR015800
INTERPRO:
 IPR015802
INTERPRO:
 IPR016182
MODBASE:
 P46883
PANTHER:
 PTHR10638
PDB:
 2WOH
PDB:
 6EZZ
PDB:
 2WOF
PDB:
 2WO0
PDB:
 2WGQ
PDB:
 2W0Q
PDB:
 1SPU
PDB:
 1QAL
PDB:
 1QAK
PDB:
 1QAF
PDB:
 1OAC
PDB:
 1LVN
PDB:
 1JRQ
PDB:
 1DYU
PDB:
 1D6Z
PDB:
 1D6U
PDB:
 1D6Y
PFAM:
 PF01179
PFAM:
 PF02727
PFAM:
 PF02728
PFAM:
 PF07833
PRIDE:
 P46883
PRODB:
 PRO_000024148
PROSITE:
 PS01164
PROSITE:
 PS01165
REFSEQ:
 NP_415904
SMR:
 P46883
UNIPROT:
 P46883


Operon      
Name: tynA         
Operon arrangement:
Transcription unit        Promoter
tynA


Transcriptional Regulation      
Display Regulation             
Activated by: FeaR


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Steinebach V., Benen JA., Bader R., Postma PW., De Vries S., Duine JA., 1996, Cloning of the maoA gene that encodes aromatic amine oxidase of Escherichia coli W3350 and characterization of the overexpressed enzyme., Eur J Biochem 237(3):584-91

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