RegulonDB RegulonDB 10.9: Gene Form
   

gpsA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gpsA cysE secB grxC CRP RyhB TSS_4189 TSS_4189 TSS_4188 TSS_4188 secBp secBp TSS_4186 TSS_4186 gpsAp5 gpsAp5 gpsAp8 gpsAp8 TSS_4185 TSS_4185 TSS_4184 TSS_4184 TSS_4183 (cluster) TSS_4183 (cluster) cysEp cysEp

Gene      
Name: gpsA    Texpresso search in the literature
Synonym(s): ECK3598, EG20091, b3608
Genome position(nucleotides): 3782642 <-- 3783661 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
56.76
External database links:  
ASAP:
ABE-0011795
CGSC:
663
ECHOBASE:
EB4142
ECOLIHUB:
gpsA
MIM:
614480
OU-MICROARRAY:
b3608
STRING:
511145.b3608
COLOMBOS: gpsA


Product      
Name: glycerol-3-phosphate dehydrogenase
Synonym(s): GpsA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 36.362
Isoelectric point: 6.517
Motif(s):
 
Type Positions Sequence
12 -> 17 GAGSYG
259 -> 260 RN
184 -> 323 DFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVQSAQEKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREA
8 -> 163 MTVIGAGSYGTALAITLARNGHEVVLWGHDPEHIATLERDRCNAAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFGEVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDQTF

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.6 - misc. glycerol metabolism
  1 - metabolism --> 1.8 - metabolism of other compounds --> 1.8.1 - phosphorous metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0009331 - glycerol-3-phosphate dehydrogenase complex
molecular_function GO:0016491 - oxidoreductase activity
GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0047952 - glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO:0004367 - glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0042803 - protein homodimerization activity
GO:0051287 - NAD binding
biological_process GO:0005975 - carbohydrate metabolic process
GO:0006629 - lipid metabolic process
GO:0006650 - glycerophospholipid metabolic process
GO:0008654 - phospholipid biosynthetic process
GO:0046474 - glycerophospholipid biosynthetic process
GO:0006072 - glycerol-3-phosphate metabolic process
GO:0046167 - glycerol-3-phosphate biosynthetic process
GO:0046168 - glycerol-3-phosphate catabolic process
GO:0055114 - oxidation-reduction process
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-48003N
ECOCYC:
GLYC3PDEHYDROGBIOSYN-MONOMER
ECOLIWIKI:
b3608
INTERPRO:
IPR008927
INTERPRO:
IPR036291
INTERPRO:
IPR013328
INTERPRO:
IPR011128
INTERPRO:
IPR006168
INTERPRO:
IPR006109
MODBASE:
P0A6S7
PFAM:
PF01210
PFAM:
PF07479
PRIDE:
P0A6S7
PRINTS:
PR00077
PRODB:
PRO_000022833
PROSITE:
PS00957
REFSEQ:
NP_418065
SMR:
P0A6S7
UNIPROT:
P0A6S7


Operon      
Name: yibN-grxC-secB-gpsA         
Operon arrangement:
Transcription unit        Promoter
secB-gpsA
yibN-grxC-secB-gpsA
grxC
yibN


Transcriptional Regulation      
Display Regulation             
Activated by: CRP


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4183 (cluster) 3783637 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_4184 3783640 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4185 3783644 reverse nd [RS-EPT-CBR] [1]
  promoter gpsAp8 3783681 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter gpsAp5 3783810 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_4186 3784160 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4188 3784234 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4189 3784239 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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