RegulonDB RegulonDB 10.10: Gene Form
   

uxuR gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

uxuB yjiC uxuR UxuR UxuR ExuR UxuR TSS_5143 (cluster) TSS_5143 (cluster) TSS_5142 TSS_5142 uxuRp uxuRp

Gene      
Name: uxuR    Texpresso search in the literature
Synonym(s): ECK4315, EG20249, b4324
Genome position(nucleotides): 4554576 --> 4555349 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.62
External database links:  
ASAP:
 ABE-0014179
CGSC:
 12
ECHOBASE:
 EB4151
ECOLIHUB:
 uxuR
OU-MICROARRAY:
 b4324
STRING:
 511145.b4324
COLOMBOS: uxuR


Product      
Name: DNA-binding transcriptional repressor UxuR
Synonym(s): UxuR
Sequence: Get amino acid sequence Fasta Format
Regulator Family: GntR
Cellular location: cytosol
Molecular weight: 29.308
Isoelectric point: 4.762
Motif(s):
 
Type Positions Sequence
10 -> 73 PYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV
8 -> 76 QRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDN
97 -> 225 ELLQARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATHNSMLVELFRQSWQWRENNPMWIQLHSHLDDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLE
36 -> 55 EREIAEMLDVTRTVVREALI

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
  3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
biological_process GO:0006351 - transcription, DNA-templated
GO:0006355 - regulation of transcription, DNA-templated
Note(s): Note(s): ...[more].
Evidence: [IEP] Inferred from expression pattern
Reference(s): [1] Blanco C. 1987
[2] Blanco C., et al., 1986
External database links:  
DIP:
 DIP-11110N
ECOCYC:
 EG20249-MONOMER
ECOLIWIKI:
 b4324
INTERPRO:
 IPR036390
INTERPRO:
 IPR036388
INTERPRO:
 IPR000524
INTERPRO:
 IPR008920
INTERPRO:
 IPR011711
MODBASE:
 P39161
PFAM:
 PF00392
PFAM:
 PF07729
PRIDE:
 P39161
PRINTS:
 PR00035
PRODB:
 PRO_000024208
PROSITE:
 PS50949
REFSEQ:
 NP_418744
SMART:
 SM00895
SMART:
 SM00345
SMR:
 P39161
UNIPROT:
 P39161


Operon      
Name: uxuR         
Operon arrangement:
Transcription unit        Promoter
uxuR


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: ExuR, UxuR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_5142 4554477 forward nd [RS-EPT-CBR] [3]
  promoter TSS_5143 (cluster) 4554479 forward nd [RS-EPT-CBR] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Blanco C., 1987, Transcriptional and translational signals of the uidA gene in Escherichia coli K12., Mol Gen Genet 208(3):490-8

 [2] Blanco C., Ritzenthaler P., Kolb A., 1986, The regulatory region of the uxuAB operon in Escherichia coli K12., Mol Gen Genet 202(1):112-9

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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