RegulonDB RegulonDB 10.7: Gene Form
   

cyaR gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

trhP ogrK cyaR CRP cyaRp cyaRp

Gene      
Name: cyaR    Texpresso search in the literature
Synonym(s): ECK2078, G0-8878, b4438, ryeE
Genome position(nucleotides): 2167114 --> 2167200 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
42.53
External database links:  
ASAP:
ABE-0047258
ECHOBASE:
EB4522
PORTECO:
cyaR
REGULONDB:
b4438
M3D: cyaR
COLOMBOS: cyaR
PortEco: cyaR


Product      
Name: CyaR
Synonym(s): RyeE, ryeE, small regulatory RNA CyaR
Type: small RNA
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.2 - RNA related --> 2.2.7 - antisense RNA
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.6 - antisense RNA
Gene Ontology Terms (GO)  
molecular_function GO:0005515 - protein binding
GO:0003729 - mRNA binding
GO:0048027 - mRNA 5'-UTR binding
biological_process GO:0070928 - regulation of mRNA stability, ncRNA-mediated
Note(s): Note(s): ...[more].
Evidence: [IDA] Inferred from direct assay
[IMP] Inferred from mutant phenotype
Reference(s): [1] De Lay N., et al., 2009
[2] Johansen J., et al., 2008
[3] Mihailovic MK., et al., 2018
[4] Sylwan L., et al., 2010
[5] Wassarman KM., et al., 2001
External database links:  
ECOCYC:
RYEE-RNA
ECOLIWIKI:
b4438


Operon      
Name: cyaR         
Operon arrangement:
Transcription unit        Promoter
cyaR


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: CpxR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] De Lay N., Gottesman S., 2009, The Crp-activated small noncoding regulatory RNA CyaR (RyeE) links nutritional status to group behavior., J Bacteriol 191(2):461-76

 [2] Johansen J., Eriksen M., Kallipolitis B., Valentin-Hansen P., 2008, Down-regulation of Outer Membrane Proteins by Noncoding RNAs: Unraveling the cAMP-CRP- and sigma(E)-Dependent CyaR-ompX Regulatory Case., J Mol Biol 383(1):1-9

 [3] Mihailovic MK., Vazquez-Anderson J., Li Y., Fry V., Vimalathas P., Herrera D., Lease RA., Powell WB., Contreras LM., 2018, High-throughput in vivo mapping of RNA accessible interfaces to identify functional sRNA binding sites., Nat Commun 9(1):4084

 [4] Sylwan L., Frumerie C., Haggard-Ljungquist E., 2010, Identification of bases required for P2 integrase core binding and recombination., Virology 404(2):240-5

 [5] Wassarman KM., Repoila F., Rosenow C., Storz G., Gottesman S., 2001, Identification of novel small RNAs using comparative genomics and microarrays., Genes Dev 15(13):1637-51


RegulonDB