RegulonDB

RegulonDB RegulonDB 10.8: Gene Form

hokC gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	hokC
Synonym(s):	ECK0017, G0-9563, b4412, gef
Genome position(nucleotides):	16751 <-- 16903 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	52.94
External database links:

ASAP:	ABE-0047278
ECHOBASE:	EB0368
ECOO157CYC:	GEF
PortEco:	hokC
STRING:	511145.b4412
COLOMBOS:	hokC

Product

Name:

protein HokC

Synonym(s):

Gef, HokC, HokC, Gef toxin; interferes with membrane function when in excess

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane,periplasmic space

Molecular weight:

5.502

Isoelectric point:

7.424

Motif(s):

Type	Positions	Sequence
	6 -> 47	AMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAY
	41 -> 41	V
	30 -> 30	C
	15 -> 15	C
	29 -> 29	L

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		5 - cell processes --> 5.6 - protection --> 5.6.3 - cell killing
Gene Ontology Terms (GO)
Gene Ontology Terms (GO)	cellular_component	GO:0016020 - membrane GO:0042597 - periplasmic space GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane

Note(s):

Note(s): ...[more].

External database links:

ECOCYC:

ECOLIWIKI:

ECOO157CYC:

INTERPRO:

INTERPRO:

PFAM:

PRIDE:

PRINTS:

PRODB:

PRODOM:

PROSITE:

REFSEQ:

UNIPROT:

Operon

Name:

mokC-hokC

Operon arrangement:

Transcription unit	Promoter

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_39	15463	forward	nd	[RS-EPT-CBR]	[1]
promoter	TSS_40	15553	forward	nd	[RS-EPT-CBR]	[1]
promoter	hokCp4	16951	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.208. P-value: 8.961e-5 Read more >	[ICWHO]	[2]
promoter	TSS_41	16961	reverse	nd	[RS-EPT-CBR]	[1]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

Reference(s)

[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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