RegulonDB

Gene
Name:	ldrA
Synonym(s):	ECK1204, G0-9602, b4419
Genome position(nucleotides):	1269168 <-- 1269275 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	55.56
External database links:

ASAP:	ABE-0047280
ECHOBASE:	EB4335
ECOLIHUB:	ldrA
COLOMBOS:	ldrA

Product

Name:

small toxic polypeptide LdrA

Synonym(s):

LdrA

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

4.014

Isoelectric point:

11.477

Motif(s):

Type	Positions	Sequence
	3 -> 32	LAQFAMIFWHDLAAPILAGIITAAIVSWWR
	1 -> 35	MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		5 - cell processes --> 5.6 - protection --> 5.6.3 - cell killing
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane
	biological_process	GO:0008219 - cell death GO:0012501 - programmed cell death

Note(s):

Note(s): ...[more].

Evidence:

[HIFS] Human inference of function from sequence
[IE] Inferred from experiment

Reference(s):

[1] Kawano M., et al., 2002
[2] Yamaguchi Y., et al., 2014

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

PFAM:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

ldrA

Operon arrangement:

Transcription unit	Promoter
ldrA

RNA cis-regulatory element

Attenuation:	Translational

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	rdlAp5	1269323		forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.696. P-value: 1.481e-5 Read more >	[ICWHO]	[3]

Evidence
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Kawano M., Oshima T., Kasai H., Mori H., 2002, Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli., Mol Microbiol 45(2):333-49
[2] Yamaguchi Y., Tokunaga N., Inouye M., Phadtare S., 2014, Characterization of LdrA (Long Direct Repeat A) Protein of Escherichia coli., J Mol Microbiol Biotechnol 24(2):91-97
[3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78