RegulonDB RegulonDB 10.8: Gene Form
   

sgrS gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

sgrR setA sgrS sgrT SgrR Cra DksA DksA ppGpp ppGpp terminator anti-terminator anti-anti-terminator sgrSp sgrSp sgrRp sgrRp

Gene      
Name: sgrS    Texpresso search in the literature
Synonym(s): ECK0071, G0-9941, b4577, ryaA
Genome position(nucleotides): 77367 --> 77593 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
47.58
External database links:  
ASAP:
ABE-0285090
ECHOBASE:
EB4546
PortEco:
sgrS
COLOMBOS: sgrS


Product      
Name: SgrS
Synonym(s): RyaA, ryaA, small regulatory RNA SgrS
Type: small RNA
Classification:
Multifun Terms (GenProtEC)  
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.6 - antisense RNA
Gene Ontology Terms (GO)  
molecular_function GO:0005515 - protein binding
GO:0003729 - mRNA binding
biological_process GO:0006950 - response to stress
GO:0040033 - negative regulation of translation, ncRNA-mediated
GO:0045975 - positive regulation of translation, ncRNA-mediated
GO:0070928 - regulation of mRNA stability, ncRNA-mediated
GO:1900192 - positive regulation of single-species biofilm formation
GO:1902201 - negative regulation of bacterial-type flagellum-dependent cell motility
Note(s): Note(s): ...[more].
Evidence: [IDA] Inferred from direct assay
[IE] Inferred from experiment
[IMP] Inferred from mutant phenotype
Reference(s): [1] Kawamoto H., et al., 2005
[2] Malecka EM., et al., 2015
[3] Mihailovic MK., et al., 2018
[4] Sun Y., et al., 2013
[5] Vanderpool CK., et al., 2004
External database links:  
ECOCYC:
RNA0-241
ECOLIWIKI:
b4577


Operon      
Name: sgrST-setA         
Operon arrangement:
Transcription unit        Promoter
sgrST-setA


Transcriptional Regulation      
Display Regulation             
Activated by: SgrR
Repressed by: Cra


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Kawamoto H., Morita T., Shimizu A., Inada T., Aiba H., 2005, Implication of membrane localization of target mRNA in the action of a small RNA: mechanism of post-transcriptional regulation of glucose transporter in Escherichia coli., Genes Dev 19(3):328-38

 [2] Malecka EM., Strozecka J., Sobanska D., Olejniczak M., 2015, Structure of bacterial regulatory RNAs determines their performance in competition for the chaperone protein Hfq., Biochemistry 54(5):1157-70

 [3] Mihailovic MK., Vazquez-Anderson J., Li Y., Fry V., Vimalathas P., Herrera D., Lease RA., Powell WB., Contreras LM., 2018, High-throughput in vivo mapping of RNA accessible interfaces to identify functional sRNA binding sites., Nat Commun 9(1):4084

 [4] Sun Y., Vanderpool CK., 2013, Physiological consequences of multiple-target regulation by the small RNA SgrS in Escherichia coli., J Bacteriol 195(21):4804-15

 [5] Vanderpool CK., Gottesman S., 2004, Involvement of a novel transcriptional activator and small RNA in post-transcriptional regulation of the glucose phosphoenolpyruvate phosphotransferase system., Mol Microbiol 54(4):1076-89


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