RegulonDB RegulonDB 10.10: Gene Form
   

nanT gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

nanT nanA nanE nanK terminator

Gene      
Name: nanT    Texpresso search in the literature
Synonym(s): ECK3213, G436, b3224
Genome position(nucleotides): 3371084 <-- 3372574 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
55.06
External database links:  
ASAP:
ABE-0010577
CGSC:
18121
ECHOBASE:
EB4145
ECOLIHUB:
nanT
OU-MICROARRAY:
b3224
STRING:
511145.b3224
COLOMBOS: nanT


Product      
Name: N-acetylneuraminate:H+ symporter
Synonym(s): NanT, sialic acid transporter NanT
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 53.551
Isoelectric point: 9.838
Motif(s):
 
Type Positions Sequence
278 -> 298 VMLMVVVLFAFLYSWPIQALL
406 -> 426 FTYNVGALGGALAPIIGALIA
431 -> 451 LGTALASLSFSLTFVVILLIG
22 -> 42 FSAAWLGYLLDGFDFVLIALV
355 -> 375 IIPVFAIGGANVWVLGLLLFF

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.12 - amino sugar conversions
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015538 - sialic acid:proton symporter activity
biological_process GO:0015739 - sialic acid transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
[2] Martinez J., et al., 1995
[3] Rodriguez-Aparicio LB., et al., 1987
[4] Severi E., et al., 2010
External database links:  
ECOCYC:
NANT-MONOMER
ECOLIWIKI:
b3224
INTERPRO:
IPR011701
INTERPRO:
IPR036259
INTERPRO:
IPR020846
INTERPRO:
IPR004742
MODBASE:
P41036
PFAM:
PF07690
PRIDE:
P41036
PROSITE:
PS50850
REFSEQ:
NP_417691
UNIPROT:
P41036


Operon      
Name: nanATEKQ         
Operon arrangement:
Transcription unit        Promoter
nanA
nanATEK-yhcH


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: NanR, Fis


RNA cis-regulatory element    
Attenuation: Translational


Regulation by small RNA    
  Display Regulation
small RNA spf


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Martinez J., Steenbergen S., Vimr E., 1995, Derived structure of the putative sialic acid transporter from Escherichia coli predicts a novel sugar permease domain., J Bacteriol 177(20):6005-10

 [3] Rodriguez-Aparicio LB., Reglero A., Luengo JM., 1987, Uptake of N-acetylneuraminic acid by Escherichia coli K-235. Biochemical characterization of the transport system., Biochem J 246(2):287-94

 [4] Severi E., Hosie AH., Hawkhead JA., Thomas GH., 2010, Characterization of a novel sialic acid transporter of the sodium solute symporter (SSS) family and in vivo comparison with known bacterial sialic acid transporters., FEMS Microbiol Lett 304(1):47-54


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