RegulonDB

Gene
Name:	ecpR
Synonym(s):	ECK0293, G6165, b0294, matA, ykgK
Genome position(nucleotides):	310746 <-- 311336 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	39.09
External database links:

ASAP:	ABE-0001011
ECHOBASE:	EB4070
OU-MICROARRAY:	b0294
PortEco:	matA
STRING:	511145.b0294
COLOMBOS:	ecpR

Product

Name:

DNA-binding transcriptional dual regulator MatA

Synonym(s):

EcpR, MatA, YkgK

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

LuxR/UhpA

Cellular location:

cytosol

Molecular weight:

23.274

Isoelectric point:

9.78

Motif(s):

Type	Positions	Sequence
	138 -> 196	KDIKKDKITDREMEIIRMTAQGMQPKSIARIENCSVKTVYTHRRNAEAKLYSKIYKLVQ
	162 -> 181	PKSIARIENCSVKTVYTHRR
	145 -> 187	ITDREMEIIRMTAQGMQPKSIARIENCSVKTVYTHRRNAEAKL
	179 -> 179	H

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding
	biological_process	GO:0006355 - regulation of transcription, DNA-templated GO:1902021 - regulation of bacterial-type flagellum-dependent cell motility

Note(s):

Note(s): ...[more].

Evidence:

[AIFS] Automated inference of function from sequence
[APPHINH] Assay of protein purified to homogeneity from its native host
[IEP] Inferred from expression pattern

Reference(s):

[1] Lehti TA., et al., 2012
[2] Perez-Rueda E., et al., 2004

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PRIDE:

PRINTS:

PROSITE:

REFSEQ:

SMART:

SMR:

UNIPROT:

Operon

Name:

ecpR

Operon arrangement:

Transcription unit	Promoter
ecpR	ecpRp

Transcriptional Regulation
	Display Regulation
Activated by:	MatA

RNA cis-regulatory element

Attenuation:	Translational

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	matAp9	311432	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.053. P-value: 3.830e-5 Read more >	[ICWHO]	[3]
promoter	matAp5	311446	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 2.856. P-value: 5.947e-5 Read more >	[ICWHO]	[3]
promoter	matAp10	311460	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.09. P-value: 3.653e-6 Read more >	[ICWHO]	[3]
promoter	matAp7	311482	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.734. P-value: 1.902e-5 Read more >	[ICWHO]	[3]
promoter	ykgLp1	311939	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: -3.05. P-value: 4.773e-5 Read more >	[ICWHO]	[3]

Evidence
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Lehti TA., Bauchart P., Dobrindt U., Korhonen TK., Westerlund-Wikstrom B., 2012, The fimbriae activator MatA switches off motility in Escherichia coli by repression of the flagellar master operon flhDC., Microbiology 158(Pt 6):1444-55
[2] Perez-Rueda E., Collado-Vides J., Segovia L., 2004, Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea., Comput Biol Chem 28(5-6):341-50
[3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78