RegulonDB RegulonDB 11.1: Gene Form
   

prpD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

prpE prpD prpC

Gene      
Name: prpD    Texpresso search in the literature
Synonym(s): ECK0331, G6199, acnC, b0334, yahT
Genome position(nucleotides): 351215 --> 352666
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.96
External database links:  
ASAP:
 ABE-0001152
ECHOBASE:
 EB3371
ECOLIHUB:
 prpD
OU-MICROARRAY:
 b0334
STRING:
 511145.b0334
COLOMBOS: prpD


Product      
Name: 2-methylcitrate dehydratase
Synonym(s): AcnC, PrpD, YahT
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 53.952
Isoelectric point: 5.855
Motif(s):
 
Type Positions Sequence Comment
2 -> 483 SAQINNIRPEFDREIVDIVDYVMNYEISSKVAYDTAHYCLLDTLGCGLEALEYPACKKLLGPIVPGTVVPNGVRVPGTQFQLDPVQAAFNIGAMIRWLDFNDTWLAAEWGHPSDNLGGILATADWLSRNAVASGKAPLTMKQVLTAMIKAHEIQGCIALENSFNRVGLDHVLLVKVASTAVVAEMLGLTREEILNAVSLAWVDGQSLRTYRHAPNTGTRKSWAAGDATSRAVRLALMAKTGEMGYPSALTAPVWGFYDVSFKGESFRFQRPYGSYVMENVLFKISFPAEFHSQTAVEAAMTLYEQMQAAGKTAADIEKVTIRTHEACIRIIDKKGPLNNPADRDHCIQYMVAIPLLFGRLTAADYEDNVAQDKRIDALREKINCFEDPAFTADYHDPEKRAIANAITLEFTDGTRFEEVVVEYPIGHARRRQDGIPKLVDKFKINLARQFPTRQQQRILEVSLDRARLEQMPVNEYLDLYVI UniProt: 2-methylcitrate dehydratase.
18 -> 269 DIVDYVMNYEISSKVAYDTAHYCLLDTLGCGLEALEYPACKKLLGPIVPGTVVPNGVRVPGTQFQLDPVQAAFNIGAMIRWLDFNDTWLAAEWGHPSDNLGGILATADWLSRNAVASGKAPLTMKQVLTAMIKAHEIQGCIALENSFNRVGLDHVLLVKVASTAVVAEMLGLTREEILNAVSLAWVDGQSLRTYRHAPNTGTRKSWAAGDATSRAVRLALMAKTGEMGYPSALTAPVWGFYDVSFKGESFRF
287 -> 462 FPAEFHSQTAVEAAMTLYEQMQAAGKTAADIEKVTIRTHEACIRIIDKKGPLNNPADRDHCIQYMVAIPLLFGRLTAADYEDNVAQDKRIDALREKINCFEDPAFTADYHDPEKRAIANAITLEFTDGTRFEEVVVEYPIGHARRRQDGIPKLVDKFKINLARQFPTRQQQRILEV

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.2 - fatty acids
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0047780 - citrate dehydratase activity
GO:0016829 - lyase activity
GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0003994 - aconitate hydratase activity
GO:0047547 - 2-methylcitrate dehydratase activity
biological_process GO:0006099 - tricarboxylic acid cycle
GO:0019679 - propionate metabolic process, methylcitrate cycle
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P77243
DIP:
 DIP-10580N
ECOCYC:
 G6199-MONOMER
ECOLIWIKI:
 b0334
INTERPRO:
 IPR042183
INTERPRO:
 IPR036148
INTERPRO:
 IPR005656
INTERPRO:
 IPR012705
INTERPRO:
 IPR042188
MODBASE:
 P77243
PANTHER:
 PTHR16943
PDB:
 1SZQ
PFAM:
 PF19305
PFAM:
 PF03972
PRIDE:
 P77243
PRODB:
 PRO_000023608
REFSEQ:
 NP_414868
SMR:
 P77243
UNIPROT:
 P77243


Operon      
Name: prpBCDE         
Operon arrangement:
Transcription unit        Promoter
prpBCDE


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, PrpR
Repressed by: Cra


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



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