Gene
Name:	macA
Synonym(s):	ECK0869, G6461, b0878, ybjY
Genome position(nucleotides):	919235 --> 920350 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.05
External database links:

ASAP:	ABE-0002986
ECHOBASE:	EB3458
OU-MICROARRAY:	b0878
PortEco:	macA
STRING:	511145.b0878
COLOMBOS:	macA

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	macBp1	920094	forward	The sigma factor was determined by transcription profiling experiments and a bioinformatics approach Zhao K,2005. We assigned a putative transcriptional start site to this promoter based on the observation that the majority of the promoters, whose transcriptional start sites were determined experimentally, present a distance of 6 nucleotides between the transcriptional start site and the -10 box. Read more >	[AIPP]	[3]
promoter	macBp2	920337	forward	The sigma factor was determined by transcription profiling experiments and a bioinformatics approach Zhao K,2005 We assigned a putative transcriptional start site to this promoter based on the observation that the majority of the promoters, whose transcriptional start sites were determined experimentally, show a distance of 6 nucleotides between the transcriptional start site and the -10 box. Read more >	[AIPP]	[3]
promoter	TSS_1026	921483	forward	nd	[RS-EPT-CBR]	[4]
promoter	TSS_1027	921911	forward	nd	[RS-EPT-CBR]	[4]
promoter	TSS_1028 (cluster)	922360	forward	For this promoter, there is a cluster of 2 transcription start sites,in the interval 922360 to 922361, where the highest frequency is at position 921583. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[4]

Evidence
[AIPP] Automated inference of promoter position
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Pu Y., Zhao Z., Li Y., Zou J., Ma Q., Zhao Y., Ke Y., Zhu Y., Chen H., Baker MAB., Ge H., Sun Y., Xie XS., Bai F., 2016, Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells., Mol Cell 62(2):284-294
[2] Tikhonova EB., Dastidar V., Rybenkov VV., Zgurskaya HI., 2009, Kinetic control of TolC recruitment by multidrug efflux complexes., Proc Natl Acad Sci U S A 106(38):16416-21
[3] Zhao K., Liu M., Burgess RR., 2005, The global transcriptional response of Escherichia coli to induced sigma 32 protein involves sigma 32 regulon activation followed by inactivation and degradation of sigma 32 in vivo., J Biol Chem 280(18):17758-68
[4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.