RegulonDB RegulonDB 10.8: Gene Form
   

lolC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

lolE lolC ycfT lolD terminator nagKp3 nagKp3 TSS_1454 TSS_1454 TSS_1453 TSS_1453 TSS_1452 TSS_1452 TSS_1451 TSS_1451 TSS_1450 TSS_1450 lolCp5 lolCp5 lolCp6 lolCp6 TSS_1449 TSS_1449 ycfTp11 ycfTp11 ycfTp9 ycfTp9

Gene      
Name: lolC    Texpresso search in the literature
Synonym(s): ECK1102, G6573, b1116, ycfU
Genome position(nucleotides): 1175427 --> 1176626 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
54.17
External database links:  
ASAP:
ABE-0003772
ECHOBASE:
EB3213
OU-MICROARRAY:
b1116
PortEco:
lolC
STRING:
511145.b1116
COLOMBOS: lolC


Product      
Name: lipoprotein release complex - inner membrane subunit
Synonym(s): LolC, YcfU
Sequence: Get amino acid sequence Fasta Format
Cellular location: periplasmic space,inner membrane
Molecular weight: 43.264
Isoelectric point: 6.084
Motif(s):
 
Type Positions Sequence
25 -> 45 FVSWLSTIGITLGVMALVTVL
40 -> 40 A
172 -> 172 F
177 -> 177 R
173 -> 173 T

 

Classification:
Multifun Terms (GenProtEC)  
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0098797 - plasma membrane protein complex
molecular_function GO:0140306 - lipoprotein releasing activity
GO:0005515 - protein binding
biological_process GO:0042953 - lipoprotein transport
GO:0044874 - lipoprotein localization to outer membrane
GO:0089705 - protein localization to outer membrane
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-58651N
ECOCYC:
YCFU-MONOMER
ECOLIWIKI:
b1116
INTERPRO:
IPR011925
INTERPRO:
IPR025857
INTERPRO:
IPR003838
PDB:
6F49
PDB:
5NAA
PDB:
6F3Z
PFAM:
PF12704
PFAM:
PF02687
PRIDE:
P0ADC3
PRODB:
PRO_000023105
REFSEQ:
NP_415634
SMR:
P0ADC3
UNIPROT:
P0ADC3


Operon      
Name: lolCDE         
Operon arrangement:
Transcription unit        Promoter
 


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter ycfTp9 1175325 reverse Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter ycfTp11 1175329 reverse Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter TSS_1449 1175350 forward nd [RS-EPT-CBR] [2]
  promoter lolCp6 1175374 forward Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter lolCp5 1175399 forward Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter TSS_1450 1176220 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1451 1177193 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1452 1177616 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1453 1178231 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1454 1178238 forward nd [RS-EPT-CBR] [2]
  promoter nagKp3 1178540 forward Similarity to the consensus
Read more >
[ICWHO] [1]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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