RegulonDB

Gene
Name:	feaR
Synonym(s):	ECK1381, G6706, b1384, maoB, maoX, ydbM
Genome position(nucleotides):	1446378 <-- 1447283
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	48.57
External database links:

ASAP:	ABE-0004630
ECHOBASE:	EB3198
ECOLIHUB:	feaR
OU-MICROARRAY:	b1384
STRING:	511145.b1384
COLOMBOS:	feaR

Product

Name:

DNA-binding transcriptional activator FeaR

Synonym(s):

FeaR, MaoB, MaoX, YdbM

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

AraC/XylS

Cellular location:

cytosol

Molecular weight:

34.62

Isoelectric point:

6.868

Motif(s):

Type	Positions	Sequence	Comment
	12 -> 185	WLSQINQVCGNFTGRLLTERYTGVLDTHFAKGLKLSTVTTSGVNLSRTWQEVKGSDDAWFYTVFQLSGQAIMEQDERQVQIGAGDITLLDASRPCSLYWQESSKQISLLLPRTLLEQYFPHQKPICAERLDADLPMVQLSHRLLQESMNNPALSETESEAALQAMVCLLRPVLH
	81 -> 81	A	Ligand-binding
	83 -> 83	M	Ligand-binding
	199 -> 299	QKVVTLIDDNIREEILRPEWIAGETGMSVRSLYRMFADKGLVVAQYIRNRRLDFCADAIRHAADDEKLAGIGFHWGFSDQSHFSTVFKQRFGMTPGEYRRK	UniProt: HTH araC/xylS-type.
	217 -> 238	EWIAGETGMSVRSLYRMFADKG	UniProt: H-T-H motif.

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
		1 - metabolism --> 1.1 - carbon utilization --> 1.1.4 - amines
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.2 - activator
		3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0043565 - sequence-specific DNA binding GO:0000987 - cis-regulatory region sequence-specific DNA binding
	biological_process	GO:0006355 - regulation of transcription, DNA-templated GO:0045893 - positive regulation of transcription, DNA-templated

Note(s):

Note(s): ...[more].

Evidence:

[COMP-HINF-FN-FROM-SEQ] Human inference of function from sequence
[EXP-IEP] Inferred from expression pattern
[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis

Reference(s):

[1] Hanlon SP., et al., 1997
[2] Yamashita M., et al., 1996

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PFAM:

PRIDE:

PRINTS:

PRODB:

PROSITE:

REFSEQ:

SMART:

SMR:

UNIPROT:

Transcriptional Regulation
	Display Regulation
Activated by:	Nac, CRP, QseB
Repressed by:	NsrR, PhoB, QseB

Reference(s)
[1] Hanlon SP., Hill TK., Flavell MA., Stringfellow JM., Cooper RA., 1997, 2-phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression., Microbiology 143 ( Pt 2):513-8
[2] Yamashita M., Azakami H., Yokoro N., Roh JH., Suzuki H., Kumagai H., Murooka Y., 1996, maoB, a gene that encodes a positive regulator of the monoamine oxidase gene (maoA) in Escherichia coli., J Bacteriol 178(10):2941-7