RegulonDB

Gene
Name:	hicB
Synonym(s):	ECK1432, G6749, b1438, ydcQ
Genome position(nucleotides):	1509508 --> 1509924
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	45.56
External database links:

ASAP:	ABE-0004796
ECHOBASE:	EB3523
ECOLIHUB:	hicB
OU-MICROARRAY:	b1438
STRING:	511145.b1438
COLOMBOS:	hicB

Product

Name:

antitoxin of the HicA-HicB toxin-antitoxin system / DNA-binding transcriptional repressor HicB

Synonym(s):

HicB, YdcQ

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

HTH_3

Cellular location:

cytosol

Molecular weight:

15.247

Isoelectric point:

4.736

Motif(s):

Type	Positions	Sequence	Comment
	3 -> 67	YPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHD
	82 -> 136	LLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLV	UniProt: HTH cro/C1-type.
	88 -> 134	QSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELS
	93 -> 112	QQELARRIGKPKQEITRLFN	UniProt: H-T-H motif.

Classification:

Multifun Terms (GenProtEC)
		3 - regulation --> 3.1 - type of regulation --> 3.1.4 - unknown
		5 - cell processes --> 5.5 - adaptations
Gene Ontology Terms (GO)
	cellular_component	GO:0110001 - toxin-antitoxin complex GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0005515 - protein binding GO:0042802 - identical protein binding
	biological_process	GO:0006355 - regulation of transcription, DNA-templated GO:0006950 - response to stress GO:0040008 - regulation of growth

Note(s):

Note(s): ...[more].

Evidence:

[AIFS] Automated inference of function from sequence
[IGI] Inferred from genetic interaction
[IMP] Inferred from mutant phenotype

Reference(s):

[1] Button JE., et al., 2007
[2] Jorgensen MG., et al., 2009
[3] Perez-Rueda E., et al., 2004

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

PDB:

PDB:

PFAM:

PFAM:

PRIDE:

PROSITE:

REFSEQ:

SMART:

SMR:

UNIPROT:

Transcriptional Regulation
	Display Regulation
Activated by:	CRP
Repressed by:	HicB

Reference(s)
[1] Button JE., Silhavy TJ., Ruiz N., 2007, A suppressor of cell death caused by the loss of sigmaE downregulates extracytoplasmic stress responses and outer membrane vesicle production in Escherichia coli., J Bacteriol 189(5):1523-30
[2] Jorgensen MG., Pandey DP., Jaskolska M., Gerdes K., 2009, HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea., J Bacteriol 191(4):1191-9
[3] Perez-Rueda E., Collado-Vides J., Segovia L., 2004, Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea., Comput Biol Chem 28(5-6):341-50