RegulonDB RegulonDB 11.0: Gene Form
   

dmsD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

clcB ynfH dmsD bidA TSS_1875 TSS_1875

Gene      
Name: dmsD    Texpresso search in the literature
Synonym(s): ECK1586, G6849, b1591, ynfI
Genome position(nucleotides): 1664506 --> 1665120
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.33
External database links:  
ASAP:
 ABE-0005314
ECHOBASE:
 EB3608
ECOLIHUB:
 dmsD
OU-MICROARRAY:
 b1591
STRING:
 511145.b1591
COLOMBOS: dmsD


Product      
Name: redox enzyme maturation protein DmsD
Synonym(s): DmsD, YnfI
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,cytosol
Molecular weight: 23.345
Isoelectric point: 4.635
Motif(s):
 
Type Positions Sequence Comment
2 -> 204 THFSQQDNFSVAARVLGALFYYAPESAEAAPLVAVLTSDGWETQWPLPEASLAPLVTAFQTQCEETHAQAWQRLFVGPWALPSPPWGSVWLDRESVLFGDSTLALRQWMREKGIQFEMKQNEPEDHFGSLLLMAAWLAENGRQTECEELLAWHLFPWSTRFLDVFIEKAEHPFYRALGELARLTLAQWQSQLLIPVAVKPLFR UniProt: Tat proofreading chaperone DmsD.
7 -> 7 Q UniProt: In Ref. 4; AA sequence..
52 -> 163 SLAPLVTAFQTQCEETHAQAWQRLFVGPWALPSPPWGSVWLDRESVLFGDSTLALRQWMREKGIQFEMKQNEPEDHFGSLLLMAAWLAENGRQTECEELLAWHLFPWSTRFL
72 -> 75 WQRL UniProt: 1.5-fold increased binding to DmsA signal sequence..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.4 - energy production/transport --> 1.4.2 - electron acceptors
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane
molecular_function GO:0005515 - protein binding
GO:0005048 - signal sequence binding
biological_process GO:0061077 - chaperone-mediated protein folding
Note(s): Note(s): ...[more].
Evidence: [APPH] Assay of protein purified to homogeneity
Reference(s): [1] Sarfo KJ., et al., 2004
External database links:  
ALPHAFOLD:
 P69853
DIP:
 DIP-47840N
ECOCYC:
 G6849-MONOMER
ECOLIWIKI:
 b1591
ECOO157CYC:
 Z2581-MONOMER
INTERPRO:
 IPR020945
INTERPRO:
 IPR028611
INTERPRO:
 IPR026269
INTERPRO:
 IPR036411
MINT:
 P69853
PDB:
 3U41
PDB:
 3EFP
PDB:
 3CW0
PFAM:
 PF02613
PRIDE:
 P69853
PRODB:
 PRO_000022458
REFSEQ:
 NP_416108
SMR:
 P69853
SWISSMODEL:
 P69853
UNIPROT:
 P69853


Operon      
Name: ynfEFGH-dmsD         
Operon arrangement:
Transcription unit        Promoter
ynfEFGH-dmsD
ynfEFGH-dmsD


Transcriptional Regulation      
Display Regulation             
Activated by: FNR
Repressed by: NarL


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1875 1664208 forward nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Sarfo KJ., Winstone TL., Papish AL., Howell JM., Kadir H., Vogel HJ., Turner RJ., 2004, Folding forms of Escherichia coli DmsD, a twin-arginine leader binding protein., Biochem Biophys Res Commun 315(2):397-403

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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