RegulonDB RegulonDB 10.8: Gene Form
   

nudG gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gdhA ynjF nudG ynjH Nac Nac Nac CRP ArgP Nac ArgP terminator TSS_2070 TSS_2070 TSS_2069 TSS_2069 TSS_2068 TSS_2068 TSS_2067 TSS_2067 TSS_2066 TSS_2066 TSS_2065 TSS_2065 gdhAp1 gdhAp1 ynjHp2 ynjHp2 ynjHp ynjHp ynjFp6 ynjFp6 nudGp3 nudGp3 ynjFp ynjFp

Gene      
Name: nudG    Texpresso search in the literature
Synonym(s): ECK1757, G6954, b1759, orf135, ynjG
Genome position(nucleotides): 1841490 --> 1841897 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.9
External database links:  
ASAP:
 ABE-0005855
ECHOBASE:
 EB3765
OU-MICROARRAY:
 b1759
PortEco:
 nudG
STRING:
 511145.b1759
COLOMBOS: nudG


Product      
Name: 5-hydroxy-CTP diphosphatase
Synonym(s): NudG, Orf135, YnjG
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 15.046
Isoelectric point: 4.991
Motif(s):
 
Type Positions Sequence
77 -> 77 R
36 -> 36 G
38 -> 38 K
52 -> 52 E
53 -> 53 L

 
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.1 - DNA related
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
GO:0016787 - hydrolase activity
GO:0008413 - 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0035539 - 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO:0044715 - 8-oxo-dGDP phosphatase activity
GO:0044716 - 8-oxo-GDP phosphatase activity
biological_process GO:0006281 - DNA repair
Note(s): Note(s): ...[more].
Reference(s): [1] Kamiya H. 2008
[2] Zhang Y., et al., 2018
External database links:  
DIP:
 DIP-10376N
ECOCYC:
 G6954-MONOMER
ECOLIWIKI:
 b1759
INTERPRO:
 IPR000086
INTERPRO:
 IPR020476
INTERPRO:
 IPR020084
INTERPRO:
 IPR015797
MODBASE:
 P77788
PDB:
 2RRK
PFAM:
 PF00293
PRIDE:
 P77788
PRINTS:
 PR00502
PRODB:
 PRO_000023425
PROSITE:
 PS51462
PROSITE:
 PS00893
REFSEQ:
 NP_416273
SMR:
 P77788
UNIPROT:
 P77788


Operon      
Name: nudG         
Operon arrangement:
Transcription unit        Promoter
nudG


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter nudGp3 1841438 forward Similarity to the consensus
Read more > 		[ICWHO] [3]
  promoter ynjFp6 1841611 reverse Similarity to the consensus
Read more > 		[ICWHO] [3]
  promoter TSS_2065 1842321 forward nd [RS-EPT-CBR] [4]
  promoter TSS_2066 1842327 forward nd [RS-EPT-CBR] [4]
  promoter TSS_2067 1842332 forward nd [RS-EPT-CBR] [4]
  promoter TSS_2068 1842691 forward nd [RS-EPT-CBR] [4]
  promoter TSS_2069 1843057 forward nd [RS-EPT-CBR] [4]
  promoter TSS_2070 1843063 forward nd [RS-EPT-CBR] [4]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Kamiya H., 2008, [Mutations induced by damaged DNA precursors and their prevention by nucleotide pool sanitization and DNA repair enzymes]., Seikagaku 80(5):413-6

 [2] Zhang Y., Zbornikova E., Rejman D., Gerdes K., 2018, Novel (p)ppGpp Binding and Metabolizing Proteins of Escherichia coli., MBio 9(2)

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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