RegulonDB

Gene
Name:	pphA
Synonym(s):	ECK1837, G7011, b1838, prpA, yebX
Genome position(nucleotides):	1922313 <-- 1922969 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	47.79
External database links:

ASAP:	ABE-0006114
ECHOBASE:	EB3780
OU-MICROARRAY:	b1838
PortEco:	pphA
STRING:	511145.b1838
COLOMBOS:	pphA

Product

Name:

phosphoprotein phosphatase 1

Synonym(s):

PphA, PrpA, YebX

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

25.274

Isoelectric point:

7.454

Motif(s):

Type	Positions	Sequence
	107 -> 107	L
	18 -> 155	HIWLSGDIHGCLEQLRRKLWHCRFDPWRDLLISVGDVIDRGPQSLRCLQLLEQHWVCAVRGNHEQMAMDALASQQMSLWLMNGGDWFIALADNQQKQAKTALEKCQHLPFILEVHSRTGKHVIAHADYPDDVYEWQKD
	24 -> 24	D
	26 -> 26	H

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.3 - protein related --> 2.3.3 - posttranslational modification
		3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.2 - covalent modification, demodification, maturation
		3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.3 - inhibition / activation of enzymes
		5 - cell processes --> 5.5 - adaptations --> 5.5.2 - temperature extremes
		5 - cell processes --> 5.5 - adaptations --> 5.5.6 - other (mechanical, nutritional, oxidative stress)
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0016787 - hydrolase activity GO:0046872 - metal ion binding GO:0004721 - phosphoprotein phosphatase activity GO:0008138 - protein tyrosine/serine/threonine phosphatase activity
	biological_process	GO:0009266 - response to temperature stimulus GO:0006470 - protein dephosphorylation

Note(s):

Note(s): ...[more].

Reference(s):

[1] Li B., et al., 2005
[2] Zhang Y., et al., 2010

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PRIDE:

PRODB:

PROSITE:

REFSEQ:

SMR:

SWISSMODEL:

UNIPROT:

Reference(s)
[1] Li B., Brown EW., D'Agostino C., Leclerc JE., Cebula TA., 2005, Structure and distribution of the phosphoprotein phosphatase genes, prpA and prpB, among Shigella subgroups., Microbiology 151(Pt 8):2671-83
[2] Zhang Y., Laing C., Zhang Z., Hallewell J., You C., Ziebell K., Johnson RP., Kropinski AM., Thomas JE., Karmali M., Gannon VP., 2010, Lineage and host source are both correlated with levels of Shiga toxin 2 production by Escherichia coli O157:H7 strains., Appl Environ Microbiol 76(2):474-82

RNA cis-regulatory element

Attenuation:	Transcriptional