RegulonDB RegulonDB 10.8: Gene Form
   

exoX gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ptrB exoX yebE yobB ptrBp ptrBp TSS_2187 (cluster) TSS_2187 (cluster)

Gene      
Name: exoX    Texpresso search in the literature
Synonym(s): ECK1845, G7016, b1844, yobC
Genome position(nucleotides): 1926120 --> 1926782 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.89
External database links:  
ASAP:
ABE-0006131
ECHOBASE:
EB3785
OU-MICROARRAY:
b1844
PortEco:
exoX
STRING:
511145.b1844
COLOMBOS: exoX


Product      
Name: exonuclease X
Synonym(s): ExoX, YobC
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 25.133
Isoelectric point: 7.658
Motif(s):
 
Type Positions Sequence
4 -> 147 IIDTETCGLQGGIVEIASVDVIDGKIVNPMSHLVRPDRPISPQAMAIHRITEAMVADKPWIEDVIPHYYGSEWYVAHNASFDRRVLPEMPGEWICTMKLARRLWPGIKYSNMALYKTRKLNVQTPPGLHHHRALYDCYITAALL

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.2 - DNA
  2 - information transfer --> 2.1 - DNA related --> 2.1.4 - DNA repair
  2 - information transfer --> 2.1 - DNA related --> 2.1.5 - DNA degradation
  5 - cell processes --> 5.6 - protection --> 5.6.1 - radiation
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0044776 - DNA polymerase III, core complex
molecular_function GO:0003676 - nucleic acid binding
GO:0004518 - nuclease activity
GO:0004527 - exonuclease activity
GO:0016787 - hydrolase activity
GO:0008408 - 3'-5' exonuclease activity
biological_process GO:0006281 - DNA repair
GO:0006974 - cellular response to DNA damage stimulus
GO:0045004 - DNA replication proofreading
GO:0006298 - mismatch repair
GO:0090305 - nucleic acid phosphodiester bond hydrolysis
Note(s): Note(s): ...[more].
Evidence: [APPH] Assay of protein purified to homogeneity
[IGI] Inferred from genetic interaction
Reference(s): [1] Burdett V., et al., 2001
[2] Feschenko VV., et al., 2003
[3] Viswanathan M., et al., 2001
[4] Viswanathan M., et al., 1999
External database links:  
ECOCYC:
G7016-MONOMER
ECOLIWIKI:
b1844
INTERPRO:
IPR012337
INTERPRO:
IPR036397
INTERPRO:
IPR013520
MODBASE:
P0AEK0
PDB:
4FZZ
PDB:
4FZX
PDB:
4FZY
PFAM:
PF00929
PRIDE:
P0AEK0
PRODB:
PRO_000022556
REFSEQ:
NP_416358
SMART:
SM00479
SMR:
P0AEK0
UNIPROT:
P0AEK0


Operon      
Name: yobB-exoX         
Operon arrangement:
Transcription unit        Promoter
 


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2187 (cluster) 1926096 forward For this promoter, there
Read more >
[RS-EPT-CBR] [5]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Burdett V., Baitinger C., Viswanathan M., Lovett ST., Modrich P., 2001, In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair., Proc Natl Acad Sci U S A 98(12):6765-70

 [2] Feschenko VV., Rajman LA., Lovett ST., 2003, Stabilization of perfect and imperfect tandem repeats by single-strand DNA exonucleases., Proc Natl Acad Sci U S A 100(3):1134-9

 [3] Viswanathan M., Burdett V., Baitinger C., Modrich P., Lovett ST., 2001, Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair., J Biol Chem 276(33):31053-8

 [4] Viswanathan M., Lovett ST., 1999, Exonuclease X of Escherichia coli. A novel 3'-5' DNase and Dnaq superfamily member involved in DNA repair., J Biol Chem 274(42):30094-100

 [5] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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