RegulonDB RegulonDB 11.0: Gene Form
   

yecM gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

argS cutC yecM ppGpp terminator anti-terminator anti-anti-terminator TSS_2224 TSS_2224 argSp argSp yecMp2 yecMp2 TSS_2223 TSS_2223 yecMp3 yecMp3 cutCp2 cutCp2 micLp2 micLp2 micLp1 micLp1 TSS_2221 TSS_2221

Gene      
Name: yecM    Texpresso search in the literature
Synonym(s): ECK1876, G7025, b1875, yecL
Genome position(nucleotides): 1959280 <-- 1959846
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.79
External database links:  
ASAP:
 ABE-0006257
ECHOBASE:
 EB3181
ECOLIHUB:
 yecM
OU-MICROARRAY:
 b1875
STRING:
 511145.b1875
COLOMBOS: yecM


Product      
Name: putative metal-binding enzyme YecM
Synonym(s): YecL, YecM
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 21.205
Isoelectric point: 5.283
Motif(s):
 
Type Positions Sequence Comment
10 -> 185 LQDIASDLPRFIHALDELSRRLGLNITPLTADHISLRCHQNATAERWRRGFEQCGELLSENMINGRPICLFKLHEPVQVAHWQFSIVELPWPGEKRYPHEGWEHIEIVLPGDPETLNARALALLSDEGLSLPGISVKTSSPKGEHERLPNPTLAVTDGKTTIKFHPWSIEEIVASE
102 -> 102 G UniProt: In Ref. 4; AAA89200..
120 -> 120 G UniProt: In Ref. 4; AAA89200..
167 -> 167 G UniProt: In Ref. 4; AAA89201..

 
Classification:
Multifun Terms (GenProtEC)  
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
Note(s): Note(s): ...[more].
Evidence: [IHBCE] Inferred by a human based on computational evidence
Reference(s): [1] Zhang RG., et al., 2003
External database links:  
ALPHAFOLD:
 P52007
ECOCYC:
 G7025-MONOMER
ECOLIWIKI:
 b1875
INTERPRO:
 IPR010393
INTERPRO:
 IPR029068
MODBASE:
 P52007
PANTHER:
 PTHR37519
PDB:
 1K4N
PFAM:
 PF06185
PRIDE:
 P52007
REFSEQ:
 NP_416389
SMR:
 P52007
UNIPROT:
 P52007


Operon      
Name: yecM-cutC         
Operon arrangement:
Transcription unit        Promoter
yecM-cutC


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2221 1958648 reverse nd [RS-EPT-CBR] [2]
  promoter cutCp2 1959267 reverse nd [ICWHO] [3]
  promoter yecMp3 1959872 reverse nd [ICWHO] [3]
  promoter TSS_2223 1959873 reverse nd [RS-EPT-CBR] [2]
  promoter yecMp2 1959984 reverse nd [ICWHO] [3]
  promoter TSS_2224 1961626 forward nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Zhang RG., Duke N., Laskowski R., Evdokimova E., Skarina T., Edwards A., Joachimiak A., Savchenko A., 2003, Conserved protein YecM from Escherichia coli shows structural homology to metal-binding isomerases and oxygenases., Proteins 51(2):311-4

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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