RegulonDB

Gene
Name:	dsrA
Synonym(s):	ECK1952, G7047, b1954
Genome position(nucleotides):	2025227 <-- 2025313 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	43.68
External database links:

ASAP:	ABE-0006490
ECHOBASE:	EB4281
OU-MICROARRAY:	b1954
PortEco:	dsrA
COLOMBOS:	dsrA

Product

Name:

DsrA

Synonym(s):

DsrA small regulatory RNA; riboregulator of RpoS and H-NS production, small regulatory RNA DsrA

Type:

small RNA

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.2 - RNA related --> 2.2.7 - antisense RNA
		2 - information transfer --> 2.3 - protein related --> 2.3.2 - translation
		3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.6 - antisense RNA
		6 - cell structure --> 6.3 - surface antigens (ECA, O antigen of LPS)
Gene Ontology Terms (GO)
Gene Ontology Terms (GO)	biological_process	GO:1900191 - negative regulation of single-species biofilm formation GO:1902201 - negative regulation of bacterial-type flagellum-dependent cell motility

Note(s):

Note(s): ...[more].

Evidence:

[IDA] Inferred from direct assay
[IMP] Inferred from mutant phenotype

Reference(s):

External database links:

ECOCYC:

ECOLIWIKI:

Operon

Name:

dsrA

Operon arrangement:

Transcription unit	Promoter
dsrA	dsrAp

Transcriptional Regulation
	Display Regulation
Repressed by:	LeuO

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References

Reference(s)
[1] Chen S., Lesnik EA., Hall TA., Sampath R., Griffey RH., Ecker DJ., Blyn LB., 2002, A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome., Biosystems 65(2-3):157-77
[2] Malecka EM., Strozecka J., Sobanska D., Olejniczak M., 2015, Structure of bacterial regulatory RNAs determines their performance in competition for the chaperone protein Hfq., Biochemistry 54(5):1157-70
[3] Mihailovic MK., Vazquez-Anderson J., Li Y., Fry V., Vimalathas P., Herrera D., Lease RA., Powell WB., Contreras LM., 2018, High-throughput in vivo mapping of RNA accessible interfaces to identify functional sRNA binding sites., Nat Commun 9(1):4084
[4] Peterman N., Lavi-Itzkovitz A., Levine E., 2014, Large-scale mapping of sequence-function relations in small regulatory RNAs reveals plasticity and modularity., Nucleic Acids Res 42(19):12177-88
[5] Sledjeski D., Gottesman S., 1995, A small RNA acts as an antisilencer of the H-NS-silenced rcsA gene of Escherichia coli., Proc Natl Acad Sci U S A 92(6):2003-7