RegulonDB

Gene
Name:	rcnR
Synonym(s):	ECK2098, G7137, b2105, yohL
Genome position(nucleotides):	2185524 <-- 2185796 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	48.35
External database links:

ASAP:	ABE-0006964
ECHOBASE:	EB3823
OU-MICROARRAY:	b2105
PortEco:	rcnR
STRING:	511145.b2105
COLOMBOS:	rcnR

Product

Name:

DNA-binding transcriptional repressor RcnR

Synonym(s):

RcnR, YohL

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

RcnR_FrmR_like_DUF156

Cellular location:

cytosol

Molecular weight:

10.134

Isoelectric point:

9.209

Motif(s):

Type	Positions	Sequence
	7 -> 86	DKQKLKARASKIQGQVVALKKMLDEPHECAAVLQQIAAIRGAVNGLMREVIKGHLTEHIVHQGDELKREEDLDVVLKVLD

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0046872 - metal ion binding
	biological_process	GO:0006355 - regulation of transcription, DNA-templated GO:0045892 - negative regulation of transcription, DNA-templated

Note(s):

Note(s): ...[more].

Evidence:

[APPH] Assay of protein purified to homogeneity
[GEA] Gene expression analysis

Reference(s):

[1] Iwig JS., et al., 2009
[2] Iwig JS., et al., 2006
[3] Koch D., et al., 2007

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

PANTHER:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

rcnR

Operon arrangement:

Transcription unit	Promoter
rcnR	rcnRp

Transcriptional Regulation
	Display Regulation
Repressed by:	RcnR

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	thiDp3	2184673		reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.36. P-value: 5.381e-5 Read more >	[ICWHO]	[4]

Evidence
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Iwig JS., Chivers PT., 2009, DNA recognition and wrapping by Escherichia coli RcnR., J Mol Biol 393(2):514-26
[2] Iwig JS., Rowe JL., Chivers PT., 2006, Nickel homeostasis in Escherichia coli - the rcnR-rcnA efflux pathway and its linkage to NikR function., Mol Microbiol 62(1):252-62
[3] Koch D., Nies DH., Grass G., 2007, The RcnRA (YohLM) system of Escherichia coli: a connection between nickel, cobalt and iron homeostasis., Biometals 20(5):759-71
[4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78