RegulonDB RegulonDB 10.8: Gene Form
   

folX gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yfcH yfcG folX TSS_2617 TSS_2617 TSS_2616 TSS_2616 TSS_2615 TSS_2615 TSS_2614 TSS_2614

Gene      
Name: folX    Texpresso search in the literature
Synonym(s): ECK2297, G7195, b2303
Genome position(nucleotides): 2421325 --> 2421687 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 44.9
External database links:  
ASAP:
 ABE-0007603
ECHOBASE:
 EB4011
OU-MICROARRAY:
 b2303
PortEco:
 folX
STRING:
 511145.b2303
COLOMBOS: folX


Product      
Name: dihydroneopterin triphosphate 2'-epimerase
Synonym(s): FolX
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 14.082
Isoelectric point: 7.088
Motif(s):
 
Type Positions Sequence
2 -> 120 AQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTVTKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR
27 -> 30 NNRQ
55 -> 55 L
107 -> 107 R
8 -> 116 IRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTVTKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTL

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.1 - unassigned reversible reactions
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016853 - isomerase activity
GO:0004150 - dihydroneopterin aldolase activity
GO:0008719 - dihydroneopterin triphosphate 2'-epimerase activity
biological_process GO:0006760 - folic acid-containing compound metabolic process
External database links:  
DIP:
 DIP-9679N
ECOCYC:
 H2NTPEPIM-MONOMER
ECOLIWIKI:
 b2303
INTERPRO:
 IPR006157
PDB:
 1B9L
PFAM:
 PF02152
PRIDE:
 P0AC19
PRODB:
 PRO_000022683
REFSEQ:
 NP_416806
SMART:
 SM00905
SMR:
 P0AC19
UNIPROT:
 P0AC19


Operon      
Name: folX-yfcH         
Operon arrangement:
Transcription unit        Promoter
folX-yfcH


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2614 2421299 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2615 2421301 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2616 2421608 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2617 2421619 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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