RegulonDB RegulonDB 10.8: Gene Form
   

yfeW gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

murP yfeW yfeX TSS_2745 TSS_2745

Gene      
Name: yfeW    Texpresso search in the literature
Synonym(s): ECK2425, G7265, b2430
Genome position(nucleotides): 2548102 --> 2549406 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.88
External database links:  
ASAP:
ABE-0008012
ECHOBASE:
EB3916
OU-MICROARRAY:
b2430
PortEco:
yfeW
STRING:
511145.b2430
COLOMBOS: yfeW


Product      
Name: penicillin binding protein 4B
Synonym(s): PBP4B, YfeW
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,periplasmic space
Molecular weight: 47.752
Isoelectric point: 8.317
Motif(s):
 
Type Positions Sequence
7 -> 25 YLSLLAVSCSVSAAKYPVL
44 -> 412 DRWISQQVDVGYPSVNLLIIKDNQIVYRKAWGAAKKYDGSVLMEQPVKATTGTLYDLASNTKMYATNFALQKLMSEGKLHPDDRIAKYIPGFADSPNDTIKGKNTLRISDLLHHSGGFPADPQYPNKAVAGALYSQDKGQTLEMIKRTPLEYQPGSKHIYSDVDYMLLGFIVESVTGQPLDRYVEESIYRPLGLTHTVFNPLLKGFKPQQIAATELNGNTRDGVIHFPNIRTSTLWGQVHDEKAFYSMGGVSGHAGLFSNTGDIAVLMQTMLNGGGYGDVQLFNAETVKMFTTSSKEDATFGLGWRVNGNATMTPTFGTLASPQTYGHTGWTGTVTVIDPVNHMTIVMLSNKPHSPVADPQKNPNMFES

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.34 - murein turnover, recycling
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
GO:0031226 - intrinsic component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
GO:0004180 - carboxypeptidase activity
GO:0009002 - serine-type D-Ala-D-Ala carboxypeptidase activity
GO:0008658 - penicillin binding
biological_process GO:0006508 - proteolysis
Note(s): Note(s): ...[more].
Evidence: [APPHINH] Assay of protein purified to homogeneity from its native host
Reference(s): [1] Vega D., et al., 2006
External database links:  
DIP:
DIP-12021N
ECOCYC:
G7265-MONOMER
ECOLIWIKI:
b2430
INTERPRO:
IPR001466
INTERPRO:
IPR022849
INTERPRO:
IPR012338
MODBASE:
P77619
PFAM:
PF00144
PRIDE:
P77619
PROSITE:
PS51257
REFSEQ:
NP_416925
SMR:
P77619
UNIPROT:
P77619


Operon      
Name: murQP-yfeW         
Operon arrangement:
Transcription unit        Promoter
murQP
murQP
 


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2745 2549935 forward nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Vega D., Ayala JA., 2006, The DD-carboxypeptidase activity encoded by pbp4B is not essential for the cell growth of Escherichia coli., Arch Microbiol 185(1):23-7

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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