RegulonDB RegulonDB 10.8: Gene Form
   

focB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

Gene      
Name: focB    Texpresso search in the literature
Synonym(s): ECK2488, G7309, b2492
Genome position(nucleotides): 2613934 --> 2614782 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.24
Reference(s): [1] Andrews SC., et al., 1997
External database links:  
ASAP:
 ABE-0008206
ECHOBASE:
 EB3972
OU-MICROARRAY:
 b2492
PortEco:
 focB
STRING:
 511145.b2492
COLOMBOS: focB


Product      
Name: formate channel FocB
Synonym(s): FocB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 30.565
Isoelectric point: 8.639
Motif(s):
 
Type Positions Sequence
249 -> 269 FITANLLPVMLGNIIGGAVLV
191 -> 211 IVAMILPITLFVASGFEHCIA
69 -> 89 VGGLCFTLGFILLAVCGTSLF
113 -> 133 ALLVACGNLAGIACFSLLIWF
20 -> 273 ERIAAHKIARSKVSVFLMAMSAGVFMAIGFTFYLSVIADAPSSQALTHLVGGLCFTLGFILLAVCGTSLFTSSVMTVMAKSRGVISWRTWLINALLVACGNLAGIACFSLLIWFSGLVMSENAMWGVAVLHCAEGKMHHTFTESVSLGIMCNLMVCLALWMSYCGRSLCDKIVAMILPITLFVASGFEHCIANLFVIPFAIAIRHFAPPPFWQLAHSSADNFPALTVSHFITANLLPVMLGNIIGGAVLVSMCY

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0022857 - transmembrane transporter activity
GO:0015499 - formate transmembrane transporter activity
biological_process GO:0055085 - transmembrane transport
GO:0015724 - formate transport
GO:0019664 - mixed acid fermentation
Note(s): Note(s): ...[more].
Reference(s): [1] Andrews SC., et al., 1997
[2] Mukherjee M., et al., 2017
External database links:  
DIP:
 DIP-9671N
ECOCYC:
 FOCB-MONOMER
ECOLIWIKI:
 b2492
INTERPRO:
 IPR000292
INTERPRO:
 IPR024002
INTERPRO:
 IPR023271
MINT:
 MINT-1231949
PANTHER:
 PTHR30520
PFAM:
 PF01226
PRIDE:
 P77733
PROSITE:
 PS01006
PROSITE:
 PS01005
REFSEQ:
 NP_416987
SMR:
 P77733
UNIPROT:
 P77733


Operon      
Name: hyfABCDEFGHIJR-focB         
Operon arrangement:
Transcription unit        Promoter
hyfABCDEFGHIJR-focB


Transcriptional Regulation      
Display Regulation             
Activated by: FhlA, CRP, HyfR
Repressed by: FNR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Andrews SC., Berks BC., McClay J., Ambler A., Quail MA., Golby P., Guest JR., 1997, A 12-cistron Escherichia coli operon (hyf) encoding a putative proton-translocating formate hydrogenlyase system., Microbiology 143 ( Pt 11):3633-47

 [2] Mukherjee M., Vajpai M., Sankararamakrishnan R., 2017, Anion-selective Formate/nitrite transporters: taxonomic distribution, phylogenetic analysis and subfamily-specific conservation pattern in prokaryotes., BMC Genomics 18(1):560

RegulonDB