RegulonDB RegulonDB 10.6.3: Gene Form
   

focB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hyfR yfgO focB

Gene      
Name: focB    Texpresso search in the literature
Synonym(s): ECK2488, G7309, b2492
Genome position(nucleotides): 2613934 --> 2614782 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.24
Reference(s): [1] Andrews SC., et al., 1997
External database links:  
ASAP:
ABE-0008206
ECHOBASE:
EB3972
ECOCYC:
G7309
ECOLIHUB:
focB
OU-MICROARRAY:
b2492
REGULONDB:
b2492
STRING:
511145.b2492
M3D: focB
COLOMBOS: focB
PortEco: b2492


Product      
Name: formate channel FocB
Synonym(s): FocB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 30.565
Isoelectric point: 8.639
Motif(s):
 
Type Positions Sequence
249 -> 269 FITANLLPVMLGNIIGGAVLV
191 -> 211 IVAMILPITLFVASGFEHCIA
69 -> 89 VGGLCFTLGFILLAVCGTSLF
113 -> 133 ALLVACGNLAGIACFSLLIWF
20 -> 273 ERIAAHKIARSKVSVFLMAMSAGVFMAIGFTFYLSVIADAPSSQALTHLVGGLCFTLGFILLAVCGTSLFTSSVMTVMAKSRGVISWRTWLINALLVACGNLAGIACFSLLIWFSGLVMSENAMWGVAVLHCAEGKMHHTFTESVSLGIMCNLMVCLALWMSYCGRSLCDKIVAMILPITLFVASGFEHCIANLFVIPFAIAIRHFAPPPFWQLAHSSADNFPALTVSHFITANLLPVMLGNIIGGAVLVSMCY

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0022857 - transmembrane transporter activity
GO:0015499 - formate transmembrane transporter activity
biological_process GO:0055085 - transmembrane transport
GO:0015724 - formate transport
GO:0019664 - mixed acid fermentation
Note(s): Note(s): ...[more].
Evidence: [HIFS] Human inference of function from sequence
Reference(s): [1] Andrews SC., et al., 1997
[2] Mukherjee M., et al., 2017
External database links:  
DIP:
DIP-9671N
ECOCYC:
FOCB-MONOMER
ECOLIWIKI:
b2492
INTERPRO:
IPR024002
INTERPRO:
IPR000292
INTERPRO:
IPR023271
MINT:
MINT-1231949
PANTHER:
PTHR30520
PFAM:
PF01226
PRIDE:
P77733
PROSITE:
PS01006
PROSITE:
PS01005
PROTEINMODELPORTAL:
P77733
REFSEQ:
NP_416987
SMR:
P77733
UNIPROT:
P77733


Operon      
Name: hyfABCDEFGHIJR-focB         
Operon arrangement:
Transcription unit        Promoter
hyfABCDEFGHIJR-focB


Transcriptional Regulation      
Display Regulation             
Activated by: FhlA, CRP, HyfR
Repressed by: FNR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Andrews SC., Berks BC., McClay J., Ambler A., Quail MA., Golby P., Guest JR., 1997, A 12-cistron Escherichia coli operon (hyf) encoding a putative proton-translocating formate hydrogenlyase system., Microbiology 143 ( Pt 11):3633-47

 [2] Mukherjee M., Vajpai M., Sankararamakrishnan R., 2017, Anion-selective Formate/nitrite transporters: taxonomic distribution, phylogenetic analysis and subfamily-specific conservation pattern in prokaryotes., BMC Genomics 18(1):560


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