RegulonDB

Gene
Name:	yqjA
Synonym(s):	ECK3086, G7609, b3095, ecfL
Genome position(nucleotides):	3247773 --> 3248435 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.68
External database links:

ASAP:	ABE-0010181
ECHOBASE:	EB2596
OU-MICROARRAY:	b3095
PortEco:	yqjA
STRING:	511145.b3095
COLOMBOS:	yqjA

Product

Name:

DedA family protein YqjA

Synonym(s):

EcfL, YqjA

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

24.585

Isoelectric point:

9.999

Motif(s):

Type	Positions	Sequence
	192 -> 212	LMLLPVVLLVFGLAGSLVVLW
	28 -> 48	LYFVLFVILFLENGLLPAAFL
	51 -> 51	D
	48 -> 173	LPGDSLLVLVGVLIAKGAMGYPQTILLLTVAASLGCWVSYIQGRWLGNTRTVQNWLSHLPAHYHQRAHHLFHKHGLSALLIGRFIAFVRTLLPTIAGLSGLNNARFQFFNWMSGLLWVLILTTLGY
	74 -> 94	LLTVAASLGCWVSYIQGRWLG

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.4 - energy production/transport
		6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane
	molecular_function	GO:0022857 - transmembrane transporter activity
	biological_process	GO:0042493 - response to drug GO:0043093 - FtsZ-dependent cytokinesis GO:0055085 - transmembrane transport

Note(s):

Note(s): ...[more].

Evidence:

[IGI] Inferred from genetic interaction

Reference(s):

[1] Kumar A., et al., 2016
[2] Kumar S., et al., 2014

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

PANTHER:

PFAM:

PRIDE:

REFSEQ:

UNIPROT:

Operon

Name:

yqjA-mzrA

Operon arrangement:

Transcription unit	Promoter
yqjA-mzrA	yqjAp1
yqjA-mzrA	yqjAp2

Transcriptional Regulation
	Display Regulation
Activated by:	CpxR

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_3393	3247928	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_3394	3248132	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_3395	3248267	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_3396	3248277	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_3397	3248288	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_3398	3248312	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_3399 (cluster)	3248314	forward	For this promoter, there is a cluster of 4 transcription start sites,in the interval 3248314 to 3248317, where the highest frequency is at position 3246338. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[3]
promoter	TSS_3400 (cluster)	3248319	forward	For this promoter, there is a cluster of 5 transcription start sites,in the interval 3248319 to 3248323, where the highest frequency is at position 3246342. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[3]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Kumar A., Beloglazova N., Bundalovic-Torma C., Phanse S., Deineko V., Gagarinova A., Musso G., Vlasblom J., Lemak S., Hooshyar M., Minic Z., Wagih O., Mosca R., Aloy P., Golshani A., Parkinson J., Emili A., Yakunin AF., Babu M., 2016, Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli., Cell Rep 14(3):648-61
[2] Kumar S., Doerrler WT., 2014, Members of the conserved DedA family are likely membrane transporters and are required for drug resistance in Escherichia coli., Antimicrob Agents Chemother 58(2):923-30
[3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.