RegulonDB RegulonDB 10.9: Gene Form
   

cpxP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

cpxR cpxP cpxQ cpxA CpxR CpxR CpxR TSS_4598 TSS_4598 TSS_4597 TSS_4597 TSS_4596 TSS_4596 cpxPp cpxPp cpxRp cpxRp TSS_4594 TSS_4594 cpxAp1 cpxAp1

Gene      
Name: cpxP    Texpresso search in the literature
Synonym(s): ECK3906, G7816, b3913, b4484, yiiO
Genome position(nucleotides): 4105820 --> 4106320 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
50.1
Reference(s): [1] Danese PN., et al., 1998
External database links:  
ASAP:
ABE-0174117
ECHOBASE:
EB1818
ECOLIHUB:
cpxP
ECOO157CYC:
YIIO
OU-MICROARRAY:
b3913
STRING:
511145.b4484
COLOMBOS: cpxP


Shine dalgarno      
Sequence: agattttgggAGCAAAtgATG


Product      
Name: periplasmic protein CpxP
Synonym(s): CpxP, YiiO
Sequence: Get amino acid sequence Fasta Format
Cellular location: periplasmic space
Molecular weight: 18.965
Isoelectric point: 6.898
Motif(s):
 
Type Positions Sequence
124 -> 128 LTPEQ
51 -> 69 LTEHQRQQMRDLMQQARHE
103 -> 103 A
128 -> 128 Q
60 -> 60 R

 

Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.4 - complex regulation --> 3.1.2.4.3 - two component regulatory systems (external signal)
  5 - cell processes --> 5.5 - adaptations --> 5.5.4 - pH
  5 - cell processes --> 5.5 - adaptations --> 5.5.6 - other (mechanical, nutritional, oxidative stress)
Gene Ontology Terms (GO)  
cellular_component GO:0030288 - outer membrane-bounded periplasmic space
GO:0042597 - periplasmic space
molecular_function GO:0005515 - protein binding
GO:0051082 - unfolded protein binding
GO:0042802 - identical protein binding
biological_process GO:0006950 - response to stress
GO:0030162 - regulation of proteolysis
GO:1990507 - ATP-independent chaperone mediated protein folding
External database links:  
DIP:
DIP-47937N
ECOCYC:
G7816-MONOMER
ECOLIWIKI:
b4484
ECOO157CYC:
YIIO-MONOMER
INTERPRO:
IPR012899
PDB:
3ITF
PDB:
3QZC
PFAM:
PF07813
PRIDE:
P0AE85
PRODB:
PRO_000022325
REFSEQ:
YP_026277
SMR:
P0AE85
UNIPROT:
P0AE85


Operon      
Name: cpxPQ         
Operon arrangement:
Transcription unit        Promoter
cpxPQ


Transcriptional Regulation      
Display Regulation             
Activated by: CpxR


Regulation by small RNA    
  Display Regulation
small RNA cpxQ


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter cpxAp1 4105101 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_4594 4105685 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_4596 4106222 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4597 4106224 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4598 4106290 forward nd [RS-EPT-CBR] [3]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Danese PN., Silhavy TJ., 1998, CpxP, a stress-combative member of the Cpx regulon., J Bacteriol 180(4):831-9

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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