RegulonDB

Gene
Name:	cpxP
Synonym(s):	ECK3906, G7816, b3913, b4484, yiiO
Genome position(nucleotides):	4105820 --> 4106320 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.1
Reference(s):	[1] Danese PN., et al., 1998
External database links:

ASAP:	ABE-0174117
ECHOBASE:	EB1818
ECOLIHUB:	cpxP
ECOO157CYC:	YIIO
OU-MICROARRAY:	b3913
STRING:	511145.b4484
COLOMBOS:	cpxP

Shine dalgarno
Sequence:	agattttgggAGCAAAtgATG

Product

Name:

periplasmic protein CpxP

Synonym(s):

CpxP, YiiO

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

periplasmic space

Molecular weight:

18.965

Isoelectric point:

6.898

Motif(s):

Type	Positions	Sequence
	124 -> 128	LTPEQ
	51 -> 69	LTEHQRQQMRDLMQQARHE
	103 -> 103	A
	128 -> 128	Q
	60 -> 60	R

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.4 - complex regulation --> 3.1.2.4.3 - two component regulatory systems (external signal)
		5 - cell processes --> 5.5 - adaptations --> 5.5.4 - pH
		5 - cell processes --> 5.5 - adaptations --> 5.5.6 - other (mechanical, nutritional, oxidative stress)
Gene Ontology Terms (GO)
	cellular_component	GO:0030288 - outer membrane-bounded periplasmic space GO:0042597 - periplasmic space
	molecular_function	GO:0005515 - protein binding GO:0051082 - unfolded protein binding GO:0042802 - identical protein binding
	biological_process	GO:0006950 - response to stress GO:0030162 - regulation of proteolysis GO:1990507 - ATP-independent chaperone mediated protein folding

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

ECOO157CYC:

INTERPRO:

PDB:

PDB:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

cpxPQ

Operon arrangement:

Transcription unit	Promoter
cpxPQ	cpxPp

Transcriptional Regulation
	Display Regulation
Activated by:	CpxR

Regulation by small RNA
	Display Regulation
small RNA	cpxQ

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	cpxAp1	4105101	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: 0.0. P-value: 3.051e-6 Read more >	[ICWHO]	[2]
promoter	TSS_4594	4105685	reverse	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4596	4106222	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4597	4106224	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4598	4106290	forward	nd	[RS-EPT-CBR]	[3]

Evidence
[ICWHO] Inferred computationally without human oversight
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Danese PN., Silhavy TJ., 1998, CpxP, a stress-combative member of the Cpx regulon., J Bacteriol 180(4):831-9
[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
[3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.