RegulonDB RegulonDB 10.8: Gene Form
   

srlA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mltB srlE srlA srlB CRP CRP srlAp srlAp TSS_3016 TSS_3016

Gene      
Name: srlA    Texpresso search in the literature
Synonym(s): ECK2697, G8210, b2702, gutA, sbl, srlA-1
Genome position(nucleotides): 2825832 --> 2826395 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
50.18
External database links:  
ASAP:
ABE-0008890
ECHOBASE:
EB0962
OU-MICROARRAY:
b2702
PortEco:
srlA
STRING:
511145.b2702
COLOMBOS: srlA


Product      
Name: sorbitol-specific PTS enzyme IIC2 component
Synonym(s): Enzyme IIC sorbitol, GutA, Sbl, SrlA, enzyme IIC component of sorbitol PTS
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 20.58
Isoelectric point: 8.609
Motif(s):
 
Type Positions Sequence
5 -> 171 ITHGAEWFIGLFQKGGEVFTGMVTGILPLLISLLVIMNALINFIGQHRIERFAQRCAGNPVSRYLLLPCIGTFVFCNPMTLSLGRFMPEKYKPSYYAAASYSCHSMNGLFPHINPGELFVYLGIASGLTTLNLPLGPLAVSYLLVGLVTNFFRGWVTDLTTAIFEKK
68 -> 88 YLLLPCIGTFVFCNPMTLSLG
132 -> 152 LTTLNLPLGPLAVSYLLVGLV
1 -> 187 MIETITHGAEWFIGLFQKGGEVFTGMVTGILPLLISLLVIMNALINFIGQHRIERFAQRCAGNPVSRYLLLPCIGTFVFCNPMTLSLGRFMPEKYKPSYYAAASYSCHSMNGLFPHINPGELFVYLGIASGLTTLNLPLGPLAVSYLLVGLVTNFFRGWVTDLTTAIFEKKMGIQLEQKVHLAGATS
29 -> 49 GILPLLISLLVIMNALINFIG

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.4 - Group Translocators --> 4.4.A - Phosphotransferase Systems (PEP-dependent PTS)
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
biological_process GO:0008643 - carbohydrate transport
GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
External database links:  
ECOCYC:
G8210-MONOMER
ECOLIWIKI:
b2702
INTERPRO:
IPR004699
PANTHER:
PTHR40399
PFAM:
PF03608
PRIDE:
P56579
PRODB:
PRO_000023983
PROSITE:
PS51107
REFSEQ:
YP_026180
SMR:
P56579
UNIPROT:
P56579


Operon      
Name: srlAEBD-gutM-srlR-gutQ         
Operon arrangement:
Transcription unit        Promoter
srlAEBD-gutM-srlR-gutQ
srlR


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, H-NS, GutM
Repressed by: SrlR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3016 2825541 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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