RegulonDB

Gene
Name:	cpxQ
Synonym(s):	ECK4573, G0-16649, b4716
Genome position(nucleotides):	4106330 --> 4106387 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	48.28

Product

Name:

small regulatory RNA CpxQ

Synonym(s):

CpxQ

Type:

small RNA

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional
Gene Ontology Terms (GO)
	molecular_function	GO:0048027 - mRNA 5'-UTR binding
	biological_process	GO:0017148 - negative regulation of translation GO:0070928 - regulation of mRNA stability, ncRNA-mediated GO:0036460 - cellular response to cell envelope stress

Note(s):

Note(s): ...[more].

Evidence:

[IGI] Inferred from genetic interaction
[IMP] Inferred from mutant phenotype

Reference(s):

[1] Grabowicz M., et al., 2016

External database links:

ECOCYC:

Operon

Name:

cpxPQ

Operon arrangement:

Transcription unit	Promoter
cpxPQ	cpxPp

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_4596	4106222	forward	nd	[RS-EPT-CBR]	[2]
promoter	TSS_4597	4106224	forward	nd	[RS-EPT-CBR]	[2]
promoter	TSS_4598	4106290	forward	nd	[RS-EPT-CBR]	[2]
promoter	fieFp3	4106432	forward	nd	[ICWHO]	[3]
promoter	fieFp4	4106449	forward	nd	[ICWHO], [RS-EPT-CBR]	[2], [3]
promoter	TSS_4600 (cluster)	4107207	forward	nd	[RS-EPT-CBR]	[2]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Grabowicz M., Koren D., Silhavy TJ., 2016, The CpxQ sRNA Negatively Regulates Skp To Prevent Mistargeting of β-Barrel Outer Membrane Proteins into the Cytoplasmic Membrane., MBio 7(2):e00312-16
[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78