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Zur Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          


Gensor Unit       
Name: Zur
Description: Molecular biology level
Detailed: In the presence of zinc, Zur negatively regulates the expression of genes required for zinc import and response to zinc starvation. Under these condition, Zur is modified to Zur-zinc, binds its target sites preventing the expression of its regulated genes. In the absence of zinc, Zur unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the presence of zinc, Zur negatively regulates the expression of genes needed for zinc import and response to zinc starvation.

Physiology level
Detailed: The presence of zinc inhibits the expression of genes involved with zinc import and zinc starvation. Under these conditions, the genes necessary for import of zinc are not expressed.
Less detailed: The presence of zinc inhibits the expression of genes needful for import of zinc.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0007155 - cell adhesion
GO:0034224 - cellular response to zinc ion starvation
GO:0006811 - ion transport
GO:0030001 - metal ion transport
GO:0046686 - response to cadmium ion
GO:0010043 - response to zinc ion
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cellular_component GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0005737 - cytoplasm
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0030529 - intracellular ribonucleoprotein complex
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
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molecular_function GO:0005524 - ATP binding
GO:0042626 - ATPase activity, coupled to transmembrane movement of substances
GO:0046870 - cadmium ion binding
GO:0000006 - high-affinity zinc transmembrane transporter activity
GO:0046872 - metal ion binding
GO:0003735 - structural constituent of ribosome
GO:0022857 - transmembrane transporter activity
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Components: Show/Hide Components Table (19 more...)
Function Name Type
protein YkgM protein
protein YkgO protein
protein ZinT protein
simple_molecule Zinc simple_molecule
simple_molecule Zinc_Ext simple_molecule
protein ZnuA protein
protein ZnuB protein
protein ZnuC protein
complex ZnuC-ZnuB-ZnuA complex
protein Zur protein
complex Zur-Zinc complex
gene ykgMO gene
RNA ykgMO_mRNA RNA
gene zinT gene
RNA zinT_mRNA RNA
gene znuA gene
RNA znuA_mRNA RNA
gene znuCB gene
RNA znuCB_mRNA RNA


Reactions       
Showing 13 reactions
Zinc + Zur Zur-Zinc
Name: Zinc + Zur -> Zur-Zinc
Description: Reaction transforming Zinc, Zur into Zur-Zinc
Type: state transition
Pathway Components: Zinc + Zur -> Zur-Zinc
Components:
Function Name Type Evidence Reference(s)
reactant Zinc simple_molecule nd nd
reactant Zur protein nd nd
product Zur-Zinc complex nd nd
Zur-Zinc ykgMO ykgMO_mRNA
Name: ykgMO -> ykgMO_mRNA
Description: Transcription of transcription unit ykgMO. Reaction inhibition by Zur-Zinc.
Type: transcription
Pathway Components: ykgMO - Zur-Zinc -> ykgMO_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor Zur-Zinc complex nd nd
reactant ykgMO gene nd nd
product ykgMO_mRNA RNA nd nd
Zur-Zinc zinT zinT_mRNA
Name: zinT -> zinT_mRNA
Description: Transcription of transcription unit zinT. Reaction inhibition by Zur-Zinc.
Type: transcription
Pathway Components: zinT - Zur-Zinc -> zinT_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor Zur-Zinc complex nd nd
reactant zinT gene nd nd
product zinT_mRNA RNA nd nd
Zur-Zinc znuA znuA_mRNA
Name: znuA -> znuA_mRNA
Description: Transcription of transcription unit znuA. Reaction inhibition by Zur-Zinc.
Type: transcription
Pathway Components: znuA - Zur-Zinc -> znuA_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor Zur-Zinc complex nd nd
reactant znuA gene nd nd
product znuA_mRNA RNA nd nd
Zur-Zinc znuCB znuCB_mRNA
Name: znuCB -> znuCB_mRNA
Description: Transcription of transcription unit znuCB. Reaction inhibition by Zur-Zinc.
Type: transcription
Pathway Components: znuCB - Zur-Zinc -> znuCB_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor Zur-Zinc complex nd nd
reactant znuCB gene nd nd
product znuCB_mRNA RNA nd nd
znuA_mRNA ZnuA
Name: znuA_mRNA -> ZnuA
Description: Translation of ZnuA
Type: translation
Pathway Components: znuA_mRNA -> ZnuA
Components:
Function Name Type Evidence Reference(s)
product ZnuA protein nd nd
reactant znuA_mRNA RNA nd nd
ZnuC + ZnuA + ZnuB ZnuC-ZnuB-ZnuA
Name: ZnuC + ZnuA + ZnuB -> ZnuC-ZnuB-ZnuA
Description: Reaction transforming ZnuC, ZnuA, ZnuB into ZnuC-ZnuB-ZnuA
Type: state transition
Pathway Components: ZnuC + ZnuA + ZnuB -> ZnuC-ZnuB-ZnuA
Components:
Function Name Type Evidence Reference(s)
reactant ZnuA protein nd nd
reactant ZnuB protein nd nd
reactant ZnuC protein nd nd
product ZnuC-ZnuB-ZnuA complex nd nd
ZnuC-ZnuB-ZnuA Zinc_Ext Zinc
Name: Zinc_Ext -> Zinc
Description: Transport of Zinc_Ext through a bacterial membrane, leading to the presence of Zinc inside the cell.
Type: transport
Pathway Components: Zinc_Ext - ZnuC-ZnuB-ZnuA -> Zinc
Components:
Function Name Type Evidence Reference(s)
product Zinc simple_molecule nd nd
reactant Zinc_Ext simple_molecule nd nd
catalyzer ZnuC-ZnuB-ZnuA complex nd nd
zinT_mRNA ZinT
Name: zinT_mRNA -> ZinT
Description: Translation of ZinT
Type: translation
Pathway Components: zinT_mRNA -> ZinT
Components:
Function Name Type Evidence Reference(s)
product ZinT protein nd nd
reactant zinT_mRNA RNA nd nd
ykgMO_mRNA YkgM
Name: ykgMO_mRNA -> YkgM
Description: Translation of YkgM
Type: translation
Pathway Components: ykgMO_mRNA -> YkgM
Components:
Function Name Type Evidence Reference(s)
product YkgM protein nd nd
reactant ykgMO_mRNA RNA nd nd
ykgMO_mRNA YkgO
Name: ykgMO_mRNA -> YkgO
Description: Translation of YkgO
Type: translation
Pathway Components: ykgMO_mRNA -> YkgO
Components:
Function Name Type Evidence Reference(s)
product YkgO protein nd nd
reactant ykgMO_mRNA RNA nd nd
znuCB_mRNA ZnuC
Name: znuCB_mRNA -> ZnuC
Description: Translation of ZnuC
Type: translation
Pathway Components: znuCB_mRNA -> ZnuC
Components:
Function Name Type Evidence Reference(s)
product ZnuC protein nd nd
reactant znuCB_mRNA RNA nd nd
znuCB_mRNA ZnuB
Name: znuCB_mRNA -> ZnuB
Description: Translation of ZnuB
Type: translation
Pathway Components: znuCB_mRNA -> ZnuB
Components:
Function Name Type Evidence Reference(s)
product ZnuB protein nd nd
reactant znuCB_mRNA RNA nd nd



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