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ZntR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
Cadmium Zn Zn_Ext ZntA ZntR phosphate zntA zntA_mRNA ZntR Zn ZntR Cadmium


Gensor Unit       
Name: ZntR
Description: Molecular biology level
Detailed: In the presence of zinc, ZntR positively regulates the expression of genes required for detoxification of zinc and cadmium. Under these conditions, ZntR is modified to ZntR-zinc, binds its target sites enabling the expression of its regulated gene. In the absence of zinc, ZntR unbinds its target site preventing the expression of its regulated genes.
Less detailed: In the presence of zinc, ZntR positively regulates the expression of genes needed for detoxification of zinc and cadmium.

Physiology level
Detailed: The presence of zinc induces the expression of genes involved with detoxification of zinc (and cadmium). Under these conditions the gene necessary for efflux of zinc ion (and cadmium) is expressed.
Less detailed: The presence of zinc induces the expression of genes needful for efflux of zinc ion (and cadmium).
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0099132 - ATP hydrolysis coupled cation transmembrane transport
GO:0070574 - cadmium ion transmembrane transport
GO:0006824 - cobalt ion transport
GO:0010312 - detoxification of zinc ion
GO:0015692 - lead ion transport
GO:0035444 - nickel cation transmembrane transport
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cellular_component GO:0016021 - integral component of membrane
GO:0005886 - plasma membrane
molecular_function GO:0016887 - ATPase activity
GO:0015086 - cadmium ion transmembrane transporter activity
GO:0008551 - cadmium-exporting ATPase activity
GO:0015087 - cobalt ion transmembrane transporter activity
GO:0015094 - lead ion transmembrane transporter activity
GO:0015099 - nickel cation transmembrane transporter activity
GO:0005385 - zinc ion transmembrane transporter activity
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Components: Show/Hide Components Table (9 more...)
Function Name Type
simple_molecule Zinc simple_molecule
simple_molecule Zinc_Ext simple_molecule
protein ZntA protein
protein ZntR protein
complex ZntR-Zinc complex
complex ZntR-mercury complex
simple_molecule mercury simple_molecule
gene zntA gene
RNA zntA_mRNA RNA


Reactions       
Showing 5 reactions
Zinc + ZntR ZntR-Zinc
Name: Zinc + ZntR -> ZntR-Zinc
Description: Reaction transforming Zinc, ZntR into ZntR-Zinc
Type: state transition
Pathway Components: Zinc + ZntR -> ZntR-Zinc
Components:
Function Name Type Evidence Reference(s)
reactant Zinc simple_molecule nd nd
reactant ZntR protein nd nd
product ZntR-Zinc complex nd nd
ZntR-Zinc ZntR-mercury zntA zntA_mRNA
Name: zntA -> zntA_mRNA
Description: Transcription of transcription unit zntA. Reaction activation by ZntR-Zinc, and ZntR-mercury.
Type: transcription
Pathway Components: zntA - ZntR-Zinc - ZntR-mercury -> zntA_mRNA
Components:
Function Name Type Evidence Reference(s)
activator ZntR-Zinc complex nd nd
activator ZntR-mercury complex nd nd
reactant zntA gene nd nd
product zntA_mRNA RNA nd nd
mercury + ZntR ZntR-mercury
Name: mercury + ZntR -> ZntR-mercury
Description: Reaction transforming mercury, ZntR into ZntR-mercury
Type: state transition
Pathway Components: mercury + ZntR -> ZntR-mercury
Components:
Function Name Type Evidence Reference(s)
reactant ZntR protein nd nd
product ZntR-mercury complex nd nd
reactant mercury simple_molecule nd nd
zntA_mRNA ZntA
Name: zntA_mRNA -> ZntA
Description: Translation of ZntA
Type: translation
Pathway Components: zntA_mRNA -> ZntA
Components:
Function Name Type Evidence Reference(s)
product ZntA protein nd nd
reactant zntA_mRNA RNA nd nd
ZntA Zinc_Ext Zinc
Name: Zinc_Ext -> Zinc
Description: Transport of Zinc_Ext through a bacterial membrane, leading to the presence of Zinc inside the cell.
Type: transport
Pathway Components: Zinc_Ext - ZntA -> Zinc
Components:
Function Name Type Evidence Reference(s)
product Zinc simple_molecule nd nd
reactant Zinc_Ext simple_molecule nd nd
catalyzer ZntA protein nd nd



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