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YqjI Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
Fe+2 Ni+2 YqjH YqjI Fe(III)-siderophore yqjH yqjH_mRNA yqjI yqjI_mRNA YqjI Fe+2 YqjI Ni+2 siderophore


Gensor Unit       
Name: YqjI
Description: Molecular biology level
Detailed: In the absence of Fe2+ and Ni2+, YqjI negatively regulates the expression of genes required for siderophore metabolic process. Under these conditions, YqjI remains unmodified, binds its target sites and repress the expression of its regulated genes. In the absence of Fe2+ and Ni2+, YqjI is modified to YqjI-Fe2+ or YqjI-Ni2+, unbinds it target sites, enabling the expression of its regulated genes.
Less detailed:
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0071289 - cellular response to nickel ion
GO:0033212 - iron assimilation
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0045893 - positive regulation of transcription, DNA-templated
cellular_component GO:0005829 - cytosol
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA binding transcription factor activity
GO:0071949 - FAD binding
GO:0052851 - ferric-chelate reductase (NADPH) activity
GO:0050660 - flavin adenine dinucleotide binding
Components: Show/Hide Components Table (14 more...)
Function Name Type
simple_molecule (2,3-dihydroxybenzoylserine)3 simple_molecule
simple_molecule Fe+2 simple_molecule
protein YqjH protein
protein YqjI protein
complex YqjI-Fe+2 complex
complex YqjI-nickel complex
simple_molecule hydrolyzed ferric enterobactin complex simple_molecule
simple_molecule iron chelate simple_molecule
simple_molecule nickel simple_molecule
simple_molecule siderophore simple_molecule
gene yqjH gene
RNA yqjH_mRNA RNA
gene yqjI gene
RNA yqjI_mRNA RNA


Reactions       
Showing 8 reactions
YqjI yqjH yqjH_mRNA
Name: yqjH -> yqjH_mRNA
Description: Transcription of transcription unit yqjH. Reaction inhibition by YqjI.
Type: transcription
Pathway Components: yqjH - YqjI -> yqjH_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor YqjI protein nd nd
reactant yqjH gene nd nd
product yqjH_mRNA RNA nd nd
YqjI yqjI yqjI_mRNA
Name: yqjI -> yqjI_mRNA
Description: Transcription of transcription unit yqjI. Reaction inhibition by YqjI.
Type: transcription
Pathway Components: yqjI - YqjI -> yqjI_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor YqjI protein nd nd
reactant yqjI gene nd nd
product yqjI_mRNA RNA nd nd
YqjI + Fe+2 YqjI-Fe+2
Name: YqjI + Fe+2 -> YqjI-Fe+2
Description: Reaction transforming YqjI, Fe+2 into YqjI-Fe+2
Type: state transition
Pathway Components: YqjI + Fe+2 -> YqjI-Fe+2
Components:
Function Name Type Evidence Reference(s)
reactant Fe+2 simple_molecule nd nd
reactant YqjI protein nd nd
product YqjI-Fe+2 complex nd nd
nickel + YqjI YqjI-nickel
Name: nickel + YqjI -> YqjI-nickel
Description: Reaction transforming nickel, YqjI into YqjI-nickel
Type: state transition
Pathway Components: nickel + YqjI -> YqjI-nickel
Components:
Function Name Type Evidence Reference(s)
reactant YqjI protein nd nd
product YqjI-nickel complex nd nd
reactant nickel simple_molecule nd nd
yqjH_mRNA YqjH
Name: yqjH_mRNA -> YqjH
Description: Translation of YqjH
Type: translation
Pathway Components: yqjH_mRNA -> YqjH
Components:
Function Name Type Evidence Reference(s)
product YqjH protein nd nd
reactant yqjH_mRNA RNA nd nd
YqjH hydrolyzed ferric enterobactin complex (2,3-dihydroxybenzoylserine)3 + Fe+2
Name: hydrolyzed ferric enterobactin complex -> (2,3-dihydroxybenzoylserine)3 + Fe+2
Description: Reaction transforming hydrolyzed ferric enterobactin complex into (2,3-dihydroxybenzoylserine)3, Fe+2
Type: state transition
Pathway Components: hydrolyzed ferric enterobactin complex - YqjH -> (2,3-dihydroxybenzoylserine)3 + Fe+2
Components:
Function Name Type Evidence Reference(s)
product (2,3-dihydroxybenzoylserine)3 simple_molecule nd nd
product Fe+2 simple_molecule nd nd
catalyzer YqjH protein nd nd
reactant hydrolyzed ferric enterobactin complex simple_molecule nd nd
YqjH iron chelate siderophore + Fe+2
Name: iron chelate -> siderophore + Fe+2
Description: Reaction transforming iron chelate into siderophore, Fe+2
Type: state transition
Pathway Components: iron chelate - YqjH -> siderophore + Fe+2
Components:
Function Name Type Evidence Reference(s)
product Fe+2 simple_molecule nd nd
catalyzer YqjH protein nd nd
reactant iron chelate simple_molecule nd nd
product siderophore simple_molecule nd nd
yqjI_mRNA YqjI
Name: yqjI_mRNA -> YqjI
Description: Translation of YqjI
Type: translation
Pathway Components: yqjI_mRNA -> YqjI
Components:
Function Name Type Evidence Reference(s)
product YqjI protein nd nd
reactant yqjI_mRNA RNA nd nd



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