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XapR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
inosine xanthine XapB ribose-1-phosphate XapR phosphate xapAB_mRNA nicotinamide ribose XapA vitamin PP xapAB xanthosine xanthosine_Ext XapR xanthosine guanosine hypoxanthine guanine


Gensor Unit       
Name: XapR
Description: Molecular biology level
Detailed: In the presence of xanthosine, XapR positively regulates the expression of genes required for xanthosine transport and catabolic process. Under these conditions, XapR is modified to XapR-xanthosine, binds its target sites enabling the expression of its regulated genes. In the absence of xanthosine, XapR unbinds its target sites preventing the expression of its regulated genes.
Less detailed: In the presence of xanthosine, XapR positively regulates the expression of genes needed for xanthosine transport and catabolic process.

Physiology level
Detailed: The presence of xanthosine induces the expression of genes involved with xanthosine transport and catabolic process. Under these conditions the genes necessary for xanthosine conversion to α-D-ribose-1-phosphate are expressed.
Less detailed: The presence of xanthosine induces the expression of genes needul for xanthosine conversion to α-D-ribose-1-phosphate.
Classification:
Groups: Nucleotide transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0034355 - NAD salvage
GO:0006161 - deoxyguanosine catabolic process
GO:0006149 - deoxyinosine catabolic process
GO:0046115 - guanosine catabolic process
GO:0006148 - inosine catabolic process
GO:0006139 - nucleobase-containing compound metabolic process
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003824 - catalytic activity
GO:0047975 - guanosine phosphorylase activity
GO:0042802 - identical protein binding
GO:0047724 - inosine nucleosidase activity
GO:0005337 - nucleoside transmembrane transporter activity
GO:0004731 - purine-nucleoside phosphorylase activity
GO:0016740 - transferase activity
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Components:
  Function Name Type
  protein XapA protein
  protein XapB protein
  protein XapR protein
  complex XapR-xanthosine complex
  simple_molecule guanine simple_molecule
  simple_molecule guanosine simple_molecule
  simple_molecule hypoxanthine simple_molecule
  simple_molecule inosine simple_molecule
  simple_molecule nicotinamide ribose simple_molecule
  simple_molecule phosphate simple_molecule
  simple_molecule ribose-1-phosphate simple_molecule
  simple_molecule vitamin PP simple_molecule
  simple_molecule xanthine simple_molecule
  simple_molecule xanthosine simple_molecule
  simple_molecule xanthosine_Ext simple_molecule
  gene xapAB gene
  RNA xapAB_mRNA RNA


Reactions       
Showing 9 reactions
xanthosine + XapR XapR-xanthosine
Name: xanthosine + XapR -> XapR-xanthosine
Description: Reaction transforming xanthosine, XapR into XapR-xanthosine
Type: state transition
Pathway Components: xanthosine + XapR -> XapR-xanthosine
Components:
Function Name Type
reactant XapR protein
product XapR-xanthosine complex
reactant xanthosine simple_molecule
XapR-xanthosine xapAB xapAB_mRNA
Name: xapAB -> xapAB_mRNA
Description: Transcription of transcription unit xapAB. Reaction activation by XapR-xanthosine.
Type: transcription
Pathway Components: xapAB - XapR-xanthosine -> xapAB_mRNA
Components:
Function Name Type
activator XapR-xanthosine complex
reactant xapAB gene
product xapAB_mRNA RNA
xapAB_mRNA XapA
Name: xapAB_mRNA -> XapA
Description: Translation of XapA
Type: translation
Pathway Components: xapAB_mRNA -> XapA
Components:
Function Name Type
product XapA protein
reactant xapAB_mRNA RNA
XapA xanthosine + phosphate ribose-1-phosphate + xanthine
Name: xanthosine + phosphate -> ribose-1-phosphate + xanthine
Description: Reaction transforming xanthosine, phosphate into ribose-1-phosphate, xanthine
Type: state transition
Pathway Components: xanthosine + phosphate - XapA -> ribose-1-phosphate + xanthine
Components:
Function Name Type
catalyzer XapA protein
reactant phosphate simple_molecule
product ribose-1-phosphate simple_molecule
product xanthine simple_molecule
reactant xanthosine simple_molecule
XapA phosphate + inosine ribose-1-phosphate + hypoxanthine
Name: phosphate + inosine -> ribose-1-phosphate + hypoxanthine
Description: Reaction transforming phosphate, inosine into ribose-1-phosphate, hypoxanthine
Type: state transition
Pathway Components: phosphate + inosine - XapA -> ribose-1-phosphate + hypoxanthine
Components:
Function Name Type
catalyzer XapA protein
product hypoxanthine simple_molecule
reactant inosine simple_molecule
reactant phosphate simple_molecule
product ribose-1-phosphate simple_molecule
XapA guanosine + phosphate ribose-1-phosphate + guanine
Name: guanosine + phosphate -> ribose-1-phosphate + guanine
Description: Reaction transforming guanosine, phosphate into ribose-1-phosphate, guanine
Type: state transition
Pathway Components: guanosine + phosphate - XapA -> ribose-1-phosphate + guanine
Components:
Function Name Type
catalyzer XapA protein
product guanine simple_molecule
reactant guanosine simple_molecule
reactant phosphate simple_molecule
product ribose-1-phosphate simple_molecule
XapA nicotinamide ribose + phosphate ribose-1-phosphate + vitamin PP
Name: nicotinamide ribose + phosphate -> ribose-1-phosphate + vitamin PP
Description: Reaction transforming nicotinamide ribose, phosphate into ribose-1-phosphate, vitamin PP
Type: state transition
Pathway Components: nicotinamide ribose + phosphate - XapA -> ribose-1-phosphate + vitamin PP
Components:
Function Name Type
catalyzer XapA protein
reactant nicotinamide ribose simple_molecule
reactant phosphate simple_molecule
product ribose-1-phosphate simple_molecule
product vitamin PP simple_molecule
xapAB_mRNA XapB
Name: xapAB_mRNA -> XapB
Description: Translation of XapB
Type: translation
Pathway Components: xapAB_mRNA -> XapB
Components:
Function Name Type
product XapB protein
reactant xapAB_mRNA RNA
XapB xanthosine_Ext xanthosine
Name: xanthosine_Ext -> xanthosine
Description: Transport of xanthosine_Ext through a bacterial membrane, leading to the presence of xanthosine inside the cell.
Type: transport
Pathway Components: xanthosine_Ext - XapB -> xanthosine
Components:
Function Name Type
catalyzer XapB protein
product xanthosine simple_molecule
reactant xanthosine_Ext simple_molecule



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