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XapR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
XapA XapB XapR alpha-D-ribose-1-phosphate guanine guanosine hypoxanthine inosine phosphate xanthine xanthosine xanthosine_Ext xapAB xapAB_mRNA XapR xanthosine phosphate


Gensor Unit       
Name: XapR
Description: Molecular biology level
Detailed: In the presence of xanthosine, XapR positively regulates the expression of genes required for xanthosine transport and catabolic process. Under these conditions, XapR is modified to XapR-xanthosine, binds its target sites enabling the expression of its regulated genes. In the absence of xanthosine, XapR unbinds its target sites preventing the expression of its regulated genes.
Less detailed: In the presence of xanthosine, XapR positively regulates the expression of genes needed for xanthosine transport and catabolic process.

Physiology level
Detailed: The presence of xanthosine induces the expression of genes involved with xanthosine transport and catabolic process. Under these conditions the genes necessary for xanthosine conversion to α-D-ribose-1-phosphate are expressed.
Less detailed: The presence of xanthosine induces the expression of genes needul for xanthosine conversion to α-D-ribose-1-phosphate.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0034355 - NAD salvage
GO:0006161 - deoxyguanosine catabolic process
GO:0006149 - deoxyinosine catabolic process
GO:0046115 - guanosine catabolic process
GO:0006148 - inosine catabolic process
GO:0015949 - nucleobase-containing small molecule interconversion
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cellular_component GO:0005737 - cytoplasm
GO:0016021 - integral component of membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0047975 - guanosine phosphorylase activity
GO:0042802 - identical protein binding
GO:0047724 - inosine nucleosidase activity
GO:0005337 - nucleoside transmembrane transporter activity
GO:0004731 - purine-nucleoside phosphorylase activity
GO:0015553 - xanthosine transmembrane transporter activity
Components: Show/Hide Components Table (17 more...)
Function Name Type
protein XapA protein
protein XapB protein
protein XapR protein
complex XapR-xanthosine complex
simple_molecule guanine simple_molecule
simple_molecule guanosine simple_molecule
simple_molecule hypoxanthine simple_molecule
simple_molecule inosine simple_molecule
simple_molecule nicotinamide ribose simple_molecule
simple_molecule phosphate simple_molecule
simple_molecule ribose-1-phosphate simple_molecule
simple_molecule vitamin PP simple_molecule
simple_molecule xanthine simple_molecule
simple_molecule xanthosine simple_molecule
simple_molecule xanthosine_Ext simple_molecule
gene xapAB gene
RNA xapAB_mRNA RNA


Reactions       
Showing 9 reactions
XapR XapR-xanthosine xapAB xapAB_mRNA
Name: xapAB -> xapAB_mRNA
Description: Transcription of transcription unit xapAB. Reaction activation by XapR, and XapR-xanthosine.
Type: transcription
Pathway Components: xapAB - XapR - XapR-xanthosine -> xapAB_mRNA
Components:
Function Name Type Evidence Reference(s)
activator XapR protein nd nd
activator XapR-xanthosine complex nd nd
reactant xapAB gene nd nd
product xapAB_mRNA RNA nd nd
xanthosine + XapR XapR-xanthosine
Name: xanthosine + XapR -> XapR-xanthosine
Description: Reaction transforming xanthosine, XapR into XapR-xanthosine
Type: state transition
Pathway Components: xanthosine + XapR -> XapR-xanthosine
Components:
Function Name Type Evidence Reference(s)
reactant XapR protein nd nd
product XapR-xanthosine complex nd nd
reactant xanthosine simple_molecule nd nd
xapAB_mRNA XapA
Name: xapAB_mRNA -> XapA
Description: Translation of XapA
Type: translation
Pathway Components: xapAB_mRNA -> XapA
Components:
Function Name Type Evidence Reference(s)
product XapA protein nd nd
reactant xapAB_mRNA RNA nd nd
XapA xanthosine + phosphate ribose-1-phosphate + xanthine
Name: xanthosine + phosphate -> ribose-1-phosphate + xanthine
Description: Reaction transforming xanthosine, phosphate into ribose-1-phosphate, xanthine
Type: state transition
Pathway Components: xanthosine + phosphate - XapA -> ribose-1-phosphate + xanthine
Components:
Function Name Type Evidence Reference(s)
catalyzer XapA protein nd nd
reactant phosphate simple_molecule nd nd
product ribose-1-phosphate simple_molecule nd nd
product xanthine simple_molecule nd nd
reactant xanthosine simple_molecule nd nd
XapA phosphate + inosine ribose-1-phosphate + hypoxanthine
Name: phosphate + inosine -> ribose-1-phosphate + hypoxanthine
Description: Reaction transforming phosphate, inosine into ribose-1-phosphate, hypoxanthine
Type: state transition
Pathway Components: phosphate + inosine - XapA -> ribose-1-phosphate + hypoxanthine
Components:
Function Name Type Evidence Reference(s)
catalyzer XapA protein nd nd
product hypoxanthine simple_molecule nd nd
reactant inosine simple_molecule nd nd
reactant phosphate simple_molecule nd nd
product ribose-1-phosphate simple_molecule nd nd
XapA phosphate + guanosine ribose-1-phosphate + guanine
Name: phosphate + guanosine -> ribose-1-phosphate + guanine
Description: Reaction transforming phosphate, guanosine into ribose-1-phosphate, guanine
Type: state transition
Pathway Components: phosphate + guanosine - XapA -> ribose-1-phosphate + guanine
Components:
Function Name Type Evidence Reference(s)
catalyzer XapA protein nd nd
product guanine simple_molecule nd nd
reactant guanosine simple_molecule nd nd
reactant phosphate simple_molecule nd nd
product ribose-1-phosphate simple_molecule nd nd
XapA ribose-1-phosphate + vitamin PP nicotinamide ribose + phosphate
Name: ribose-1-phosphate + vitamin PP -> nicotinamide ribose + phosphate
Description: Reaction transforming ribose-1-phosphate, vitamin PP into nicotinamide ribose, phosphate
Type: state transition
Pathway Components: ribose-1-phosphate + vitamin PP - XapA -> nicotinamide ribose + phosphate
Components:
Function Name Type Evidence Reference(s)
catalyzer XapA protein nd nd
product nicotinamide ribose simple_molecule nd nd
product phosphate simple_molecule nd nd
reactant ribose-1-phosphate simple_molecule nd nd
reactant vitamin PP simple_molecule nd nd
xapAB_mRNA XapB
Name: xapAB_mRNA -> XapB
Description: Translation of XapB
Type: translation
Pathway Components: xapAB_mRNA -> XapB
Components:
Function Name Type Evidence Reference(s)
product XapB protein nd nd
reactant xapAB_mRNA RNA nd nd
XapB xanthosine_Ext xanthosine
Name: xanthosine_Ext -> xanthosine
Description: Transport of xanthosine_Ext through a bacterial membrane, leading to the presence of xanthosine inside the cell.
Type: transport
Pathway Components: xanthosine_Ext - XapB -> xanthosine
Components:
Function Name Type Evidence Reference(s)
catalyzer XapB protein nd nd
product xanthosine simple_molecule nd nd
reactant xanthosine_Ext simple_molecule nd nd



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