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UidR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
D-glucopyranuronate UidA UidB UidC UidR a D-glucoronoside a D-glucoronoside_Ext a glucuronide ROH uidABC uidABC_mRNA uidR uidR_mRNA


Gensor Unit       
Name: UidR
Description: Molecular biology level
Detailed: UidR negatively regulates the expression of genes required for glucuronoside transport and catabolic process. UidR binds its target sites preventing its own expression and the expression of its regulated genes.
Less detailed: UidR negatively regulates the expression of genes needed for glucuronoside transport and catabolic process.
Classification:
Groups: GUs related to carbon source utilization
Gene Ontology Terms (GO): biological_process GO:0019391 - glucuronoside catabolic process
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0051289 - protein homotetramerization
GO:0006351 - transcription, DNA-templated
GO:0055085 - transmembrane transport
cellular_component GO:0009279 - cell outer membrane
GO:0005829 - cytosol
GO:0043231 - intracellular membrane-bounded organelle
GO:0005886 - plasma membrane
molecular_function GO:0003700 - DNA binding transcription factor activity
GO:0004566 - beta-glucuronidase activity
GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0042802 - identical protein binding
GO:0000976 - transcription regulatory region sequence-specific DNA binding
GO:0005215 - transporter activity
Components: Show/Hide Components Table (13 more...)
Function Name Type
simple_molecule D-glucoronoside simple_molecule
simple_molecule D-glucoronoside_Ext simple_molecule
protein UidA protein
protein UidB protein
protein UidC protein
protein UidR protein
simple_molecule alcohol simple_molecule
simple_molecule glucopyranuronate simple_molecule
simple_molecule glucuronide simple_molecule
gene uidABC gene
RNA uidABC_mRNA RNA
gene uidR gene
RNA uidR_mRNA RNA


Reactions       
Showing 8 reactions
UidR uidABC uidABC_mRNA
Name: uidABC -> uidABC_mRNA
Description: Transcription of transcription unit uidABC. Reaction inhibition by UidR.
Type: transcription
Pathway Components: uidABC - UidR -> uidABC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor UidR protein nd nd
reactant uidABC gene nd nd
product uidABC_mRNA RNA nd nd
UidR uidR uidR_mRNA
Name: uidR -> uidR_mRNA
Description: Transcription of transcription unit uidR. Reaction inhibition by UidR.
Type: transcription
Pathway Components: uidR - UidR -> uidR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor UidR protein nd nd
reactant uidR gene nd nd
product uidR_mRNA RNA nd nd
uidABC_mRNA UidA
Name: uidABC_mRNA -> UidA
Description: Translation of UidA
Type: translation
Pathway Components: uidABC_mRNA -> UidA
Components:
Function Name Type Evidence Reference(s)
product UidA protein nd nd
reactant uidABC_mRNA RNA nd nd
UidA glucuronide glucopyranuronate + alcohol
Name: glucuronide -> glucopyranuronate + alcohol
Description: Reaction transforming glucuronide into glucopyranuronate, alcohol
Type: state transition
Pathway Components: glucuronide - UidA -> glucopyranuronate + alcohol
Components:
Function Name Type Evidence Reference(s)
catalyzer UidA protein nd nd
product alcohol simple_molecule nd nd
product glucopyranuronate simple_molecule nd nd
reactant glucuronide simple_molecule nd nd
uidABC_mRNA UidB
Name: uidABC_mRNA -> UidB
Description: Translation of UidB
Type: translation
Pathway Components: uidABC_mRNA -> UidB
Components:
Function Name Type Evidence Reference(s)
product UidB protein nd nd
reactant uidABC_mRNA RNA nd nd
UidB D-glucoronoside_Ext D-glucoronoside
Name: D-glucoronoside_Ext -> D-glucoronoside
Description: Transport of D-glucoronoside_Ext through a bacterial membrane, leading to the presence of D-glucoronoside inside the cell.
Type: transport
Pathway Components: D-glucoronoside_Ext - UidB -> D-glucoronoside
Components:
Function Name Type Evidence Reference(s)
product D-glucoronoside simple_molecule nd nd
reactant D-glucoronoside_Ext simple_molecule nd nd
catalyzer UidB protein nd nd
uidABC_mRNA UidC
Name: uidABC_mRNA -> UidC
Description: Translation of UidC
Type: translation
Pathway Components: uidABC_mRNA -> UidC
Components:
Function Name Type Evidence Reference(s)
product UidC protein nd nd
reactant uidABC_mRNA RNA nd nd
uidR_mRNA UidR
Name: uidR_mRNA -> UidR
Description: Translation of UidR
Type: translation
Pathway Components: uidR_mRNA -> UidR
Components:
Function Name Type Evidence Reference(s)
product UidR protein nd nd
reactant uidR_mRNA RNA nd nd



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