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TyrR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
phenylpyruvate ketoglutarate DAHP hydroxyphenylpyruvate ketoleucine dihydrofolate AroF AroG AroL AroM AroP CO2 erythrose-4P FolA L-glutamate L-leucine L-phenylalanine L-phenylalanine_Ext L-tryptophan L-tryptophan_Ext L-tyrosine L-tyrosine_Ext Mtr L-phenylalanine TyrA TyrB TyrP TyrR L-tyrosine YaiA an aromatic amino acid an aromatic oxo-acid aroF-tyrA aroF-tyrA_mRNA aroG aroG_mRNA aroL-yaiA-aroM aroL-yaiA-aroM_mRNA aroP aroP_mRNA chorismate folA folA_mRNA indole indole_Ext mtr mtr_mRNA phosphate PEP prephenate shikimate shikimate-5-P THF tyrB tyrB_mRNA tyrP tyrP_mRNA tyrR tyrR_mRNA TyrR L-phenylalanine TyrR L-tyrosine L-glutamate ketoglutarate


Gensor Unit       
Name: TyrR
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): GO:0019292 - tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0016491 - oxidoreductase activity
GO:0016020 - membrane
GO:0008652 - cellular amino acid biosynthetic process
GO:0006571 - tyrosine biosynthetic process
GO:0003824 - catalytic activity
GO:0015196 - L-tryptophan transmembrane transporter activity
GO:0005887 - integral component of plasma membrane
GO:0005302 - L-tyrosine transmembrane transporter activity
GO:0004665 - prephenate dehydrogenase (NADP+) activity
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Components:
Function Name Type
RNA tyrR_mRNA RNA


Reactions       
Showing 39 reactions
tyrP tyrP_mRNA
Name: tyrP -> tyrP_mRNA
Description: Transcription of transcription unit tyrP; reaction inhibition by HU.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product tyrP_mRNA RNA nd nd
reactant tyrP gene nd nd
tyrR tyrR_mRNA
Name: tyrR -> tyrR_mRNA
Description: Transcription of transcription unit tyrR; reaction inhibition by TyrR.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant tyrR gene nd nd
product tyrR_mRNA RNA nd nd
TyrR + L-phenylalanine TyrR-L-phenylalanine
Name: TyrR + L-phenylalanine -> TyrR-L-phenylalanine
Description: Reaction transforming TyrR, L-phenylalanine into TyrR-L-phenylalanine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product TyrR-L-phenylalanine complex nd nd
reactant L-phenylalanine simple molecule nd nd
reactant TyrR protein nd nd
aroG aroG_mRNA
Name: aroG -> aroG_mRNA
Description: Transcription of transcription unit aroG; reaction activation by CpxR-Phosphorylated.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product aroG_mRNA RNA nd nd
reactant aroG gene nd nd
TyrR + L-tyrosine TyrR-L-tyrosine
Name: TyrR + L-tyrosine -> TyrR-L-tyrosine
Description: Reaction transforming TyrR, L-tyrosine into TyrR-L-tyrosine
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant L-tyrosine simple molecule nd nd
product TyrR-L-tyrosine complex nd nd
reactant TyrR protein nd nd
aroF-tyrA aroF-tyrA_mRNA
Name: aroF-tyrA -> aroF-tyrA_mRNA
Description: Transcription of transcription unit aroF-tyrA; reaction inhibition by TyrR-L-tyrosine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product aroF-tyrA_mRNA RNA nd nd
reactant aroF-tyrA gene nd nd
aroL-yaiA-aroM aroL-yaiA-aroM_mRNA
Name: aroL-yaiA-aroM -> aroL-yaiA-aroM_mRNA
Description: Transcription of transcription unit aroL-yaiA-aroM; reaction inhibition by TrpR-tryptophan.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant aroL-yaiA-aroM transcription unit nd nd
product aroL-yaiA-aroM_mRNA RNA nd nd
aroP aroP_mRNA
Name: aroP -> aroP_mRNA
Description: Transcription of transcription unit aroP; reaction activation by Cra.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant aroP gene nd nd
product aroP_mRNA RNA nd nd
folA folA_mRNA
Name: folA -> folA_mRNA
Description: Transcription of transcription unit folA; reaction activation by TyrR-L-tyrosine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product folA_mRNA RNA nd nd
reactant folA gene nd nd
mtr mtr_mRNA
Name: mtr -> mtr_mRNA
Description: Transcription of transcription unit mtr; reaction inhibition by HU.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant mtr gene nd nd
product mtr_mRNA RNA nd nd
tyrB tyrB_mRNA
Name: tyrB -> tyrB_mRNA
Description: Transcription of transcription unit tyrB; reaction inhibition by TyrR-L-tyrosine.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product tyrB_mRNA RNA nd nd
reactant tyrB gene nd nd
aroL-yaiA-aroM_mRNA AroM
Name: aroL-yaiA-aroM_mRNA -> AroM
Description: Translation of AroM
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant aroL-yaiA-aroM_mRNA RNA nd nd
product aroL-yaiA-aroM_mRNA RNA nd nd
tyrP_mRNA TyrP
Name: tyrP_mRNA -> TyrP
Description: Translation of TyrP
Type: translation
Components:
Function Name Type Evidence Reference(s)
product TyrP protein nd nd
reactant tyrP_mRNA RNA nd nd
L-tyrosine_Ext L-tyrosine
Name: L-tyrosine_Ext -> L-tyrosine
Description: Transport of L-tyrosine_Ext through a bacterial membrane, leading to the presence of L-tyrosine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product L-tyrosine simple molecule nd nd
reactant L-tyrosine_Ext simple molecule nd nd
folA_mRNA FolA
Name: folA_mRNA -> FolA
Description: Translation of FolA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant folA_mRNA RNA nd nd
product FolA protein nd nd
THF dihydrofolate
Name: THF -> dihydrofolate
Description: Reaction transforming THF into dihydrofolate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product dihydrofolate simple molecule nd nd
reactant THF simple molecule nd nd
aroG_mRNA AroG
Name: aroG_mRNA -> AroG
Description: Translation of AroG
Type: translation
Components:
Function Name Type Evidence Reference(s)
product AroG protein nd nd
reactant aroG_mRNA RNA nd nd
PEP + erythrose-4P DAHP + phosphate
Name: PEP + erythrose-4P -> DAHP + phosphate
Description: Reaction transforming PEP, erythrose-4P into DAHP, phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product DAHP simple molecule nd nd
reactant PEP simple molecule nd nd
reactant erythrose-4P simple molecule nd nd
product phosphate simple molecule nd nd
aroF-tyrA_mRNA AroF
Name: aroF-tyrA_mRNA -> AroF
Description: Translation of AroF
Type: translation
Components:
Function Name Type Evidence Reference(s)
product AroF protein nd nd
reactant aroF-tyrA_mRNA RNA nd nd
aroF-tyrA_mRNA TyrA
Name: aroF-tyrA_mRNA -> TyrA
Description: Translation of TyrA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product TyrA protein nd nd
reactant aroF-tyrA_mRNA RNA nd nd
chorismate prephenate
Name: chorismate -> prephenate
Description: Reaction transforming chorismate into prephenate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant chorismate simple molecule nd nd
product prephenate simple molecule nd nd
prephenate hydroxyphenylpyruvate + CO2
Name: prephenate -> hydroxyphenylpyruvate + CO2
Description: Reaction transforming prephenate into hydroxyphenylpyruvate, CO2
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant prephenate simple molecule nd nd
product CO2 simple molecule nd nd
product hydroxyphenylpyruvate simple molecule nd nd
aroP_mRNA AroP
Name: aroP_mRNA -> AroP
Description: Translation of AroP
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant aroP_mRNA RNA nd nd
product AroP protein nd nd
L-tryptophan_Ext L-tryptophan
Name: L-tryptophan_Ext -> L-tryptophan
Description: Transport of L-tryptophan_Ext through a bacterial membrane, leading to the presence of L-tryptophan inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant L-tryptophan_Ext simple molecule nd nd
product L-tryptophan simple molecule nd nd
L-phenylalanine_Ext L-phenylalanine
Name: L-phenylalanine_Ext -> L-phenylalanine
Description: Transport of L-phenylalanine_Ext through a bacterial membrane, leading to the presence of L-phenylalanine inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
product L-phenylalanine simple molecule nd nd
reactant L-phenylalanine_Ext simple molecule nd nd
aroL-yaiA-aroM_mRNA YaiA
Name: aroL-yaiA-aroM_mRNA -> YaiA
Description: Translation of YaiA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product aroL-yaiA-aroM_mRNA RNA nd nd
reactant aroL-yaiA-aroM_mRNA RNA nd nd
tyrB_mRNA TyrB
Name: tyrB_mRNA -> TyrB
Description: Translation of TyrB
Type: translation
Components:
Function Name Type Evidence Reference(s)
product TyrB protein nd nd
reactant tyrB_mRNA RNA nd nd
an aromatic amino acid + ketoglutarate an aromatic oxo-acid + L-glutamate
Name: an aromatic amino acid + ketoglutarate -> an aromatic oxo-acid + L-glutamate
Description: Reaction transforming an aromatic amino acid, ketoglutarate into an aromatic oxo-acid, L-glutamate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant an aromatic amino acid simple molecule nd nd
product L-glutamate simple molecule nd nd
product an aromatic oxo-acid simple molecule nd nd
reactant ketoglutarate simple molecule nd nd
L-leucine + ketoglutarate ketoleucine + L-glutamate
Name: L-leucine + ketoglutarate -> ketoleucine + L-glutamate
Description: Reaction transforming L-leucine, ketoglutarate into ketoleucine, L-glutamate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant ketoglutarate simple molecule nd nd
reactant L-leucine simple molecule nd nd
product L-glutamate simple molecule nd nd
product ketoleucine simple molecule nd nd
L-tyrosine + ketoglutarate hydroxyphenylpyruvate + L-glutamate
Name: L-tyrosine + ketoglutarate -> hydroxyphenylpyruvate + L-glutamate
Description: Reaction transforming L-tyrosine, ketoglutarate into hydroxyphenylpyruvate, L-glutamate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product L-glutamate simple molecule nd nd
product hydroxyphenylpyruvate simple molecule nd nd
reactant L-tyrosine simple molecule nd nd
reactant ketoglutarate simple molecule nd nd
phenylpyruvate + L-glutamate L-phenylalanine + ketoglutarate
Name: phenylpyruvate + L-glutamate -> L-phenylalanine + ketoglutarate
Description: Reaction transforming phenylpyruvate, L-glutamate into L-phenylalanine, ketoglutarate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant L-glutamate simple molecule nd nd
product ketoglutarate simple molecule nd nd
product L-phenylalanine simple molecule nd nd
reactant phenylpyruvate simple molecule nd nd
mtr_mRNA Mtr
Name: mtr_mRNA -> Mtr
Description: Translation of Mtr
Type: translation
Components:
Function Name Type Evidence Reference(s)
product Mtr protein nd nd
reactant mtr_mRNA RNA nd nd
indole_Ext indole
Name: indole_Ext -> indole
Description: Transport of indole_Ext through a bacterial membrane, leading to the presence of indole inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant indole_Ext simple molecule nd nd
product indole simple molecule nd nd
aroL-yaiA-aroM_mRNA AroL
Name: aroL-yaiA-aroM_mRNA -> AroL
Description: Translation of AroL
Type: translation
Components:
Function Name Type Evidence Reference(s)
product aroL-yaiA-aroM_mRNA RNA nd nd
reactant aroL-yaiA-aroM_mRNA RNA nd nd
shikimate shikimate-3-phosphate
Name: shikimate -> shikimate-3-phosphate
Description: Reaction transforming shikimate into shikimate-3-phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product shikimate-3-phosphate simple molecule nd nd
reactant shikimate simple molecule nd nd
tyrR_mRNA TyrR
Name: tyrR_mRNA -> TyrR
Description: Translation of TyrR
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant tyrR_mRNA RNA nd nd
product TyrR protein nd nd
prephenate phenylpyruvate
Name: prephenate -> phenylpyruvate
Description: Transformation of prephenate into phenylpyruvate by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
reactant prephenate simple molecule nd nd
product phenylpyruvate simple molecule nd nd
shikimate-3-phosphate chorismate
Name: shikimate-3-phosphate -> chorismate
Description: Transformation of shikimate-3-phosphate into chorismate by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
product chorismate simple molecule nd nd
reactant shikimate-3-phosphate simple molecule nd nd
DAHP shikimate
Name: DAHP -> shikimate
Description: Transformation of DAHP into shikimate by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
product shikimate simple molecule nd nd
reactant DAHP simple molecule nd nd



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