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TrpR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
indole-3-glycerol-P 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate DAHP PRPP AroH AroL AroM CO2 erythrose-4P D-glyceraldehyde 3-phosphate L-glutamate L-glutamine L-serine L-tryptophan L-tryptophan_Ext Mtr 5-P-ribosyl-anthranilate TrpA TrpB TrpC TrpD TrpE TrpL TrpR L-tryptophan YaiA vitamin L1 aroH aroH_mRNA aroL-yaiA-aroM aroL-yaiA-aroM_mRNA chorismate PP indole indole_Ext mtr mtr_mRNA phosphate PEP pyruvate shikimate shikimate-5-P trpL trpLEDCBA trpLEDCBA_mRNA trpL_mRNA trpR trpR_mRNA TrpR L-tryptophan TrpE TrpD


Gensor Unit       
Name: TrpR
Description: Molecular biology level
Detailed: In the presence of tryptophan, TrpR negatively regulates the expression of genes required for tryptophan transport and biosynthetic process. Under these conditions, TrpR is modified to TrpR-tryptophan, binds its target sites preventing its own expression and the expression of its regulated genes. In the absence of effector, TrpR unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the presence of tryptophan, TrpR negatively regulates the expression of genes needed for tryptophan transport and biosynthetic process.

Physiology level
Detailed: The presence of tryptophan inhibits the expression of genes involved with tryptophan transport and biosynthetic process. Under these conditions the genes necessary for transport and synthesis of tryptophan from serine and conversion of erythrose-4P to chorismate, a precursor of tryptophan, are not expressed.
Less detailed: The presence of tryptophan inhibits the expression of genes needful for transport and synthesis of tryptophan from serine and conversion of erythrose-4P to chorismate, a precursor of tryptophan.
Classification:
Groups: GUs related to the metabolism of amino acids
Gene Ontology Terms (GO): biological_process GO:0003333 - amino acid transmembrane transport
GO:0009073 - aromatic amino acid family biosynthetic process
GO:0009058 - biosynthetic process
GO:0006355 - regulation of transcription, DNA-templated
GO:0090357 - regulation of tryptophan metabolic process
GO:0019632 - shikimate metabolic process
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cellular_component GO:0005950 - anthranilate synthase complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005887 - integral component of plasma membrane
GO:0005886 - plasma membrane
molecular_function GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity
GO:0003677 - DNA binding
GO:0022804 - active transmembrane transporter activity
GO:0004048 - anthranilate phosphoribosyltransferase activity
GO:0004049 - anthranilate synthase activity
GO:0005300 - high-affinity tryptophan transmembrane transporter activity
GO:0042802 - identical protein binding
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Components: Show/Hide Components Table (50 more...)
Function Name Type
simple_molecule 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P simple_molecule
simple_molecule 5-P-ribosyl-anthranilate simple_molecule
protein AroH protein
protein AroL protein
protein AroM protein
simple_molecule CO2 simple_molecule
simple_molecule DAHP simple_molecule
simple_molecule L-glutamate simple_molecule
protein Mtr protein
simple_molecule P-enol-pyruvate simple_molecule
simple_molecule PRPP simple_molecule
protein TrpA protein
complex TrpA-TrpB complex
protein TrpB protein
protein TrpC protein
protein TrpD protein
protein TrpE protein
complex TrpE-TrpD complex
protein TrpL protein
protein TrpR protein
complex TrpR-tryptophan complex
protein YaiA protein
gene aroH gene
RNA aroH_mRNA RNA
gene aroL-yaiA-aroM gene
RNA aroL-yaiA-aroM_mRNA RNA
simple_molecule chorismate simple_molecule
simple_molecule diphosphate simple_molecule
simple_molecule erythrose-4P simple_molecule
simple_molecule glutamine simple_molecule
simple_molecule glyceraldehyde-P simple_molecule
simple_molecule indole simple_molecule
simple_molecule indole-3-glycerol-P simple_molecule
simple_molecule indole_Ext simple_molecule
gene mtr gene
RNA mtr_mRNA RNA
simple_molecule phosphate simple_molecule
simple_molecule pyruvate simple_molecule
simple_molecule serine simple_molecule
simple_molecule shikimate simple_molecule
simple_molecule shikimate-5-P simple_molecule
gene trpL gene
gene trpLEDCBA gene
RNA trpLEDCBA_mRNA RNA
RNA trpL_mRNA RNA
gene trpR gene
RNA trpR_mRNA RNA
simple_molecule tryptophan simple_molecule
simple_molecule tryptophan_Ext simple_molecule
simple_molecule vitamin L1 simple_molecule


Reactions       
Showing 35 reactions
tryptophan + TrpR TrpR-tryptophan
Name: tryptophan + TrpR -> TrpR-tryptophan
Description: Reaction transforming tryptophan, TrpR into TrpR-tryptophan
Type: state transition
Pathway Components: tryptophan + TrpR -> TrpR-tryptophan
Components:
Function Name Type Evidence Reference(s)
reactant TrpR protein nd nd
product TrpR-tryptophan complex nd nd
reactant tryptophan simple_molecule nd nd
TrpR-tryptophan aroH aroH_mRNA
Name: aroH -> aroH_mRNA
Description: Transcription of transcription unit aroH. Reaction inhibition by TrpR-tryptophan.
Type: transcription
Pathway Components: aroH - TrpR-tryptophan -> aroH_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor TrpR-tryptophan complex nd nd
reactant aroH gene nd nd
product aroH_mRNA RNA nd nd
TrpR-tryptophan aroL-yaiA-aroM aroL-yaiA-aroM_mRNA
Name: aroL-yaiA-aroM -> aroL-yaiA-aroM_mRNA
Description: Transcription of transcription unit aroL-yaiA-aroM. Reaction inhibition by TrpR-tryptophan.
Type: transcription
Pathway Components: aroL-yaiA-aroM - TrpR-tryptophan -> aroL-yaiA-aroM_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor TrpR-tryptophan complex nd nd
reactant aroL-yaiA-aroM gene nd nd
product aroL-yaiA-aroM_mRNA RNA nd nd
TrpR-tryptophan mtr mtr_mRNA
Name: mtr -> mtr_mRNA
Description: Transcription of transcription unit mtr. Reaction inhibition by TrpR-tryptophan.
Type: transcription
Pathway Components: mtr - TrpR-tryptophan -> mtr_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor TrpR-tryptophan complex nd nd
reactant mtr gene nd nd
product mtr_mRNA RNA nd nd
TrpR-tryptophan trpLEDCBA trpLEDCBA_mRNA
Name: trpLEDCBA -> trpLEDCBA_mRNA
Description: Transcription of transcription unit trpLEDCBA. Reaction inhibition by TrpR-tryptophan.
Type: transcription
Pathway Components: trpLEDCBA - TrpR-tryptophan -> trpLEDCBA_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor TrpR-tryptophan complex nd nd
reactant trpLEDCBA gene nd nd
product trpLEDCBA_mRNA RNA nd nd
TrpR-tryptophan trpR trpR_mRNA
Name: trpR -> trpR_mRNA
Description: Transcription of transcription unit trpR. Reaction inhibition by TrpR-tryptophan.
Type: transcription
Pathway Components: trpR - TrpR-tryptophan -> trpR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor TrpR-tryptophan complex nd nd
reactant trpR gene nd nd
product trpR_mRNA RNA nd nd
TrpR trpL trpL_mRNA
Name: trpL -> trpL_mRNA
Description: Transcription of transcription unit trpL. Reaction inhibition by TrpR.
Type: transcription
Pathway Components: trpL - TrpR -> trpL_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor TrpR protein nd nd
reactant trpL gene nd nd
product trpL_mRNA RNA nd nd
mtr_mRNA Mtr
Name: mtr_mRNA -> Mtr
Description: Translation of Mtr
Type: translation
Pathway Components: mtr_mRNA -> Mtr
Components:
Function Name Type Evidence Reference(s)
product Mtr protein nd nd
reactant mtr_mRNA RNA nd nd
Mtr indole_Ext indole
Name: indole_Ext -> indole
Description: Transport of indole_Ext through a bacterial membrane, leading to the presence of indole inside the cell.
Type: transport
Pathway Components: indole_Ext - Mtr -> indole
Components:
Function Name Type Evidence Reference(s)
catalyzer Mtr protein nd nd
product indole simple_molecule nd nd
reactant indole_Ext simple_molecule nd nd
Mtr tryptophan_Ext tryptophan
Name: tryptophan_Ext -> tryptophan
Description: Transport of tryptophan_Ext through a bacterial membrane, leading to the presence of tryptophan inside the cell.
Type: transport
Pathway Components: tryptophan_Ext - Mtr -> tryptophan
Components:
Function Name Type Evidence Reference(s)
catalyzer Mtr protein nd nd
product tryptophan simple_molecule nd nd
reactant tryptophan_Ext simple_molecule nd nd
trpL_mRNA TrpL
Name: trpL_mRNA -> TrpL
Description: Translation of TrpL
Type: translation
Pathway Components: trpL_mRNA -> TrpL
Components:
Function Name Type Evidence Reference(s)
product TrpL protein nd nd
reactant trpL_mRNA RNA nd nd
aroL-yaiA-aroM_mRNA AroL
Name: aroL-yaiA-aroM_mRNA -> AroL
Description: Translation of AroL
Type: translation
Pathway Components: aroL-yaiA-aroM_mRNA -> AroL
Components:
Function Name Type Evidence Reference(s)
product AroL protein nd nd
reactant aroL-yaiA-aroM_mRNA RNA nd nd
AroL shikimate shikimate-5-P
Name: shikimate -> shikimate-5-P
Description: Reaction transforming shikimate into shikimate-5-P
Type: state transition
Pathway Components: shikimate - AroL -> shikimate-5-P
Components:
Function Name Type Evidence Reference(s)
catalyzer AroL protein nd nd
reactant shikimate simple_molecule nd nd
product shikimate-5-P simple_molecule nd nd
aroL-yaiA-aroM_mRNA YaiA
Name: aroL-yaiA-aroM_mRNA -> YaiA
Description: Translation of YaiA
Type: translation
Pathway Components: aroL-yaiA-aroM_mRNA -> YaiA
Components:
Function Name Type Evidence Reference(s)
product YaiA protein nd nd
reactant aroL-yaiA-aroM_mRNA RNA nd nd
aroL-yaiA-aroM_mRNA AroM
Name: aroL-yaiA-aroM_mRNA -> AroM
Description: Translation of AroM
Type: translation
Pathway Components: aroL-yaiA-aroM_mRNA -> AroM
Components:
Function Name Type Evidence Reference(s)
product AroM protein nd nd
reactant aroL-yaiA-aroM_mRNA RNA nd nd
trpLEDCBA_mRNA TrpL
Name: trpLEDCBA_mRNA -> TrpL
Description: Translation of TrpL
Type: translation
Pathway Components: trpLEDCBA_mRNA -> TrpL
Components:
Function Name Type Evidence Reference(s)
product TrpL protein nd nd
reactant trpLEDCBA_mRNA RNA nd nd
trpLEDCBA_mRNA TrpE
Name: trpLEDCBA_mRNA -> TrpE
Description: Translation of TrpE
Type: translation
Pathway Components: trpLEDCBA_mRNA -> TrpE
Components:
Function Name Type Evidence Reference(s)
product TrpE protein nd nd
reactant trpLEDCBA_mRNA RNA nd nd
TrpE + TrpD TrpE-TrpD
Name: TrpE + TrpD -> TrpE-TrpD
Description: Reaction transforming TrpE, TrpD into TrpE-TrpD
Type: state transition
Pathway Components: TrpE + TrpD -> TrpE-TrpD
Components:
Function Name Type Evidence Reference(s)
reactant TrpD protein nd nd
reactant TrpE protein nd nd
product TrpE-TrpD complex nd nd
TrpE-TrpD tryptophan chorismate + glutamine L-glutamate + vitamin L1 + pyruvate
Name: chorismate + glutamine -> L-glutamate + vitamin L1 + pyruvate
Description: Reaction transforming chorismate, glutamine into L-glutamate, vitamin L1 , pyruvate
Type: state transition
Pathway Components: chorismate + glutamine - TrpE-TrpD - tryptophan -> L-glutamate + vitamin L1 + pyruvate
Components:
Function Name Type Evidence Reference(s)
product L-glutamate simple_molecule nd nd
catalyzer TrpE-TrpD complex nd nd
reactant chorismate simple_molecule nd nd
reactant glutamine simple_molecule nd nd
product pyruvate simple_molecule nd nd
inhibitor tryptophan simple_molecule nd nd
product vitamin L1 simple_molecule nd nd
trpLEDCBA_mRNA TrpD
Name: trpLEDCBA_mRNA -> TrpD
Description: Translation of TrpD
Type: translation
Pathway Components: trpLEDCBA_mRNA -> TrpD
Components:
Function Name Type Evidence Reference(s)
product TrpD protein nd nd
reactant trpLEDCBA_mRNA RNA nd nd
TrpD vitamin L1 + PRPP 5-P-ribosyl-anthranilate + diphosphate
Name: vitamin L1 + PRPP -> 5-P-ribosyl-anthranilate + diphosphate
Description: Reaction transforming vitamin L1, PRPP into 5-P-ribosyl-anthranilate, diphosphate
Type: state transition
Pathway Components: vitamin L1 + PRPP - TrpD -> 5-P-ribosyl-anthranilate + diphosphate
Components:
Function Name Type Evidence Reference(s)
product 5-P-ribosyl-anthranilate simple_molecule nd nd
reactant PRPP simple_molecule nd nd
catalyzer TrpD protein nd nd
product diphosphate simple_molecule nd nd
reactant vitamin L1 simple_molecule nd nd
trpLEDCBA_mRNA TrpC
Name: trpLEDCBA_mRNA -> TrpC
Description: Translation of TrpC
Type: translation
Pathway Components: trpLEDCBA_mRNA -> TrpC
Components:
Function Name Type Evidence Reference(s)
product TrpC protein nd nd
reactant trpLEDCBA_mRNA RNA nd nd
TrpC vitamin L1 Reactants indole-3-glycerol-P + CO2
Name: 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P -> indole-3-glycerol-P + CO2
Description: Reaction transforming 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P into indole-3-glycerol-P, CO2
Type: state transition
Pathway Components: 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P - TrpC - vitamin L1 -> indole-3-glycerol-P + CO2
Components:
Function Name Type Evidence Reference(s)
reactant 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P simple_molecule nd nd
product CO2 simple_molecule nd nd
catalyzer TrpC protein nd nd
product indole-3-glycerol-P simple_molecule nd nd
inhibitor vitamin L1 simple_molecule nd nd
TrpC 5-P-ribosyl-anthranilate Products
Name: 5-P-ribosyl-anthranilate -> 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P
Description: Reaction transforming 5-P-ribosyl-anthranilate into 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P
Type: state transition
Pathway Components: 5-P-ribosyl-anthranilate - TrpC -> 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P
Components:
Function Name Type Evidence Reference(s)
product 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P simple_molecule nd nd
reactant 5-P-ribosyl-anthranilate simple_molecule nd nd
catalyzer TrpC protein nd nd
trpLEDCBA_mRNA TrpB
Name: trpLEDCBA_mRNA -> TrpB
Description: Translation of TrpB
Type: translation
Pathway Components: trpLEDCBA_mRNA -> TrpB
Components:
Function Name Type Evidence Reference(s)
product TrpB protein nd nd
reactant trpLEDCBA_mRNA RNA nd nd
TrpA-TrpB TrpB serine + indole tryptophan
Name: serine + indole -> tryptophan
Description: Reaction transforming serine, indole into tryptophan
Type: state transition
Pathway Components: serine + indole - TrpA-TrpB - TrpB -> tryptophan
Components:
Function Name Type Evidence Reference(s)
catalyzer TrpA-TrpB complex nd nd
catalyzer TrpB protein nd nd
reactant indole simple_molecule nd nd
reactant serine simple_molecule nd nd
product tryptophan simple_molecule nd nd
TrpA + TrpB TrpA-TrpB
Name: TrpA + TrpB -> TrpA-TrpB
Description: Reaction transforming TrpA, TrpB into TrpA-TrpB
Type: state transition
Pathway Components: TrpA + TrpB -> TrpA-TrpB
Components:
Function Name Type Evidence Reference(s)
reactant TrpA protein nd nd
product TrpA-TrpB complex nd nd
reactant TrpB protein nd nd
TrpA-TrpB indole-3-glycerol-P + serine glyceraldehyde-P + tryptophan
Name: indole-3-glycerol-P + serine -> glyceraldehyde-P + tryptophan
Description: Reaction transforming indole-3-glycerol-P, serine into glyceraldehyde-P, tryptophan
Type: state transition
Pathway Components: indole-3-glycerol-P + serine - TrpA-TrpB -> glyceraldehyde-P + tryptophan
Components:
Function Name Type Evidence Reference(s)
catalyzer TrpA-TrpB complex nd nd
product glyceraldehyde-P simple_molecule nd nd
reactant indole-3-glycerol-P simple_molecule nd nd
reactant serine simple_molecule nd nd
product tryptophan simple_molecule nd nd
TrpA TrpA-TrpB indole-3-glycerol-P glyceraldehyde-P + indole
Name: indole-3-glycerol-P -> glyceraldehyde-P + indole
Description: Reaction transforming indole-3-glycerol-P into glyceraldehyde-P, indole
Type: state transition
Pathway Components: indole-3-glycerol-P - TrpA - TrpA-TrpB -> glyceraldehyde-P + indole
Components:
Function Name Type Evidence Reference(s)
catalyzer TrpA protein nd nd
catalyzer TrpA-TrpB complex nd nd
product glyceraldehyde-P simple_molecule nd nd
product indole simple_molecule nd nd
reactant indole-3-glycerol-P simple_molecule nd nd
trpLEDCBA_mRNA TrpA
Name: trpLEDCBA_mRNA -> TrpA
Description: Translation of TrpA
Type: translation
Pathway Components: trpLEDCBA_mRNA -> TrpA
Components:
Function Name Type Evidence Reference(s)
product TrpA protein nd nd
reactant trpLEDCBA_mRNA RNA nd nd
trpR_mRNA TrpR
Name: trpR_mRNA -> TrpR
Description: Translation of TrpR
Type: translation
Pathway Components: trpR_mRNA -> TrpR
Components:
Function Name Type Evidence Reference(s)
product TrpR protein nd nd
reactant trpR_mRNA RNA nd nd
aroH_mRNA AroH
Name: aroH_mRNA -> AroH
Description: Translation of AroH
Type: translation
Pathway Components: aroH_mRNA -> AroH
Components:
Function Name Type Evidence Reference(s)
product AroH protein nd nd
reactant aroH_mRNA RNA nd nd
AroH DAHP tryptophan P-enol-pyruvate + erythrose-4P phosphate + DAHP
Name: P-enol-pyruvate + erythrose-4P -> phosphate + DAHP
Description: Reaction transforming P-enol-pyruvate, erythrose-4P into phosphate, DAHP
Type: state transition
Pathway Components: P-enol-pyruvate + erythrose-4P - AroH - DAHP - tryptophan -> phosphate + DAHP
Components:
Function Name Type Evidence Reference(s)
catalyzer AroH protein nd nd
inhibitor DAHP simple_molecule nd nd
product DAHP simple_molecule nd nd
reactant P-enol-pyruvate simple_molecule nd nd
reactant erythrose-4P simple_molecule nd nd
product phosphate simple_molecule nd nd
inhibitor tryptophan simple_molecule nd nd
DAHP shikimate
Name: DAHP -> shikimate
Description: Transformation of DAHP into shikimate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: DAHP / 3-DEHYDROQUINATE-SYNTHASE-RXN / 3-DEHYDROQUINATE-DEHYDRATASE-RXN / RXN-7968 / shikimate
Components:
Function Name Type Evidence Reference(s)
reactant DAHP simple_molecule nd nd
product shikimate simple_molecule nd nd
shikimate-5-P chorismate
Name: shikimate-5-P -> chorismate
Description: Transformation of shikimate-5-P into chorismate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: shikimate-5-P / 2.5.1.19-RXN / CHORISMATE-SYNTHASE-RXN / chorismate
Components:
Function Name Type Evidence Reference(s)
product chorismate simple_molecule nd nd
reactant shikimate-5-P simple_molecule nd nd



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