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TrpR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
L-glutamate chorismate aroH CO2 tryptophan AroM TrpD indole trpR_mRNA shikimate tryptophan_Ext TrpE indole-3-glycerol-P AroH trpLEDCBA tryptophan P-enol-pyruvate aroH_mRNA 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P TrpB TrpB AroL glyceraldehyde-P DAHP trpL_mRNA TrpR TrpL PRPP trpLEDCBA_mRNA TrpD trpL YaiA glutamine mtr diphosphate 5-P-ribosyl-anthranilate TrpA erythrose-4P serine mtr_mRNA aroL-yaiA-aroM_mRNA TrpA pyruvate TrpC trpR indole_Ext aroL-yaiA-aroM shikimate-5-P TrpR Mtr TrpE vitamin L1 phosphate


Gensor Unit       
Name: TrpR
Classification:
Groups: GUs related to the metabolism of amino acids
Gene Ontology Terms (GO): GO:0016833 - oxo-acid-lyase activity
GO:0003700 - transcription factor activity, sequence-specific DNA binding
GO:0045892 - negative regulation of transcription, DNA-templated
GO:0016020 - membrane
GO:0008652 - cellular amino acid biosynthetic process
GO:0005622 - intracellular
GO:0003824 - catalytic activity
GO:0090357 - regulation of tryptophan metabolic process
GO:0005887 - integral component of plasma membrane
GO:0022804 - active transmembrane transporter activity
GO:0004834 - tryptophan synthase activity
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Components:
Function Name Type
RNA trpR_mRNA RNA


Reactions       
Showing 34 reactions
TrpR + L-tryptophan TrpR-L-tryptophan
Name: TrpR + L-tryptophan -> TrpR-L-tryptophan
Description: Reaction transforming TrpR, L-tryptophan into TrpR-L-tryptophan
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant TrpR protein nd nd
reactant L-tryptophan simple molecule nd nd
product TrpR-L-tryptophan complex nd nd
aroH aroH_mRNA
Name: aroH -> aroH_mRNA
Description: Transcription of transcription unit aroH; reaction inhibition by TrpR-L-tryptophan.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant aroH gene nd nd
product aroH_mRNA RNA nd nd
aroL-yaiA-aroM aroL-yaiA-aroM_mRNA
Name: aroL-yaiA-aroM -> aroL-yaiA-aroM_mRNA
Description: Transcription of transcription unit aroL-yaiA-aroM; reaction inhibition by TrpR-L-tryptophan.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product aroL-yaiA-aroM_mRNA RNA nd nd
reactant aroL-yaiA-aroM gene nd nd
mtr mtr_mRNA
Name: mtr -> mtr_mRNA
Description: Transcription of transcription unit mtr; reaction inhibition by TrpR-L-tryptophan.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product mtr_mRNA RNA nd nd
reactant mtr gene nd nd
trpL trpL_mRNA
Name: trpL -> trpL_mRNA
Description: Transcription of transcription unit trpL; reaction inhibition by TrpR-L-tryptophan.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant trpL gene nd nd
product trpL_mRNA RNA nd nd
trpLEDCBA trpLEDCBA_mRNA
Name: trpLEDCBA -> trpLEDCBA_mRNA
Description: Transcription of transcription unit trpLEDCBA; reaction inhibition by TrpR-L-tryptophan.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
product trpLEDCBA_mRNA RNA nd nd
reactant trpLEDCBA gene nd nd
trpR trpR_mRNA
Name: trpR -> trpR_mRNA
Description: Transcription of transcription unit trpR; reaction inhibition by TrpR-L-tryptophan.
Type: transcription
Components:
Function Name Type Evidence Reference(s)
reactant trpR gene nd nd
product trpR_mRNA RNA nd nd
aroL-yaiA-aroM_mRNA AroM
Name: aroL-yaiA-aroM_mRNA -> AroM
Description: Translation of AroM
Type: translation
Components:
Function Name Type Evidence Reference(s)
product AroM protein nd nd
reactant aroL-yaiA-aroM_mRNA RNA nd nd
trpLEDCBA_mRNA TrpC
Name: trpLEDCBA_mRNA -> TrpC
Description: Translation of TrpC
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant trpLEDCBA_mRNA RNA nd nd
product TrpC protein nd nd
1-(o-carboxyphenylamino)-1′-deoxyribulose-5′-P indole-3-glycerol-P + CO2
Name: 1-(o-carboxyphenylamino)-1′-deoxyribulose-5′-P -> indole-3-glycerol-P + CO2
Description: Reaction transforming 1-(o-carboxyphenylamino)-1′-deoxyribulose-5′-P into indole-3-glycerol-P, CO2
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product indole-3-glycerol-P simple molecule nd nd
reactant 1-(o-carboxyphenylamino)-1′-deoxyribulose-5′-P simple molecule nd nd
product CO2 simple molecule nd nd
5-P-ribosyl-anthranilate 1-(o-carboxyphenylamino)-1′-deoxyribulose-5′-P
Name: 5-P-ribosyl-anthranilate -> 1-(o-carboxyphenylamino)-1′-deoxyribulose-5′-P
Description: Reaction transforming 5-P-ribosyl-anthranilate into 1-(o-carboxyphenylamino)-1′-deoxyribulose-5′-P
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant 5-P-ribosyl-anthranilate simple molecule nd nd
product 1-(o-carboxyphenylamino)-1′-deoxyribulose-5′-P simple molecule nd nd
trpLEDCBA_mRNA TrpL
Name: trpLEDCBA_mRNA -> TrpL
Description: Translation of TrpL
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant trpLEDCBA_mRNA RNA nd nd
product TrpL protein nd nd
trpR_mRNA TrpR
Name: trpR_mRNA -> TrpR
Description: Translation of TrpR
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant trpR_mRNA RNA nd nd
product TrpR protein nd nd
aroH_mRNA AroH
Name: aroH_mRNA -> AroH
Description: Translation of AroH
Type: translation
Components:
Function Name Type Evidence Reference(s)
product AroH protein nd nd
reactant aroH_mRNA RNA nd nd
PEP + erythrose-4P DAHP + phosphate
Name: PEP + erythrose-4P -> DAHP + phosphate
Description: Reaction transforming PEP, erythrose-4P into DAHP, phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant erythrose-4P simple molecule nd nd
reactant PEP simple molecule nd nd
product DAHP simple molecule nd nd
product phosphate simple molecule nd nd
aroL-yaiA-aroM_mRNA YaiA
Name: aroL-yaiA-aroM_mRNA -> YaiA
Description: Translation of YaiA
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant aroL-yaiA-aroM_mRNA RNA nd nd
product YaiA protein nd nd
trpLEDCBA_mRNA TrpD
Name: trpLEDCBA_mRNA -> TrpD
Description: Translation of TrpD
Type: translation
Components:
Function Name Type Evidence Reference(s)
product TrpD protein nd nd
reactant trpLEDCBA_mRNA RNA nd nd
TrpE + TrpD TrpE-TrpD
Name: TrpE + TrpD -> TrpE-TrpD
Description: Reaction transforming TrpE, TrpD into TrpE-TrpD
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product TrpE-TrpD complex nd nd
reactant TrpD protein nd nd
reactant TrpE protein nd nd
chorismate + L-glutamine vitamin L1 + pyruvate + L-glutamate
Name: chorismate + L-glutamine -> vitamin L1 + pyruvate + L-glutamate
Description: Reaction transforming chorismate, L-glutamine into vitamin L1, pyruvate , L-glutamate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product L-glutamate simple molecule nd nd
product pyruvate simple molecule nd nd
reactant chorismate simple molecule nd nd
product vitamin L1 simple molecule nd nd
reactant L-glutamine simple molecule nd nd
5-P-ribosyl-anthranilate + PP vitamin L1 + PRPP
Name: 5-P-ribosyl-anthranilate + PP -> vitamin L1 + PRPP
Description: Reaction transforming 5-P-ribosyl-anthranilate, PP into vitamin L1, PRPP
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product PRPP simple molecule nd nd
reactant PP simple molecule nd nd
reactant 5-P-ribosyl-anthranilate simple molecule nd nd
product vitamin L1 simple molecule nd nd
trpLEDCBA_mRNA TrpE
Name: trpLEDCBA_mRNA -> TrpE
Description: Translation of TrpE
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant trpLEDCBA_mRNA RNA nd nd
product TrpE protein nd nd
mtr_mRNA Mtr
Name: mtr_mRNA -> Mtr
Description: Translation of Mtr
Type: translation
Components:
Function Name Type Evidence Reference(s)
reactant mtr_mRNA RNA nd nd
product Mtr protein nd nd
indole_Ext indole
Name: indole_Ext -> indole
Description: Transport of indole_Ext through a bacterial membrane, leading to the presence of indole inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant indole_Ext simple molecule nd nd
product indole simple molecule nd nd
L-tryptophan_Ext L-tryptophan
Name: L-tryptophan_Ext -> L-tryptophan
Description: Transport of L-tryptophan_Ext through a bacterial membrane, leading to the presence of L-tryptophan inside the compartment.
Type: transport
Components:
Function Name Type Evidence Reference(s)
reactant L-tryptophan_Ext simple molecule nd nd
product L-tryptophan simple molecule nd nd
aroL-yaiA-aroM_mRNA AroL
Name: aroL-yaiA-aroM_mRNA -> AroL
Description: Translation of AroL
Type: translation
Components:
Function Name Type Evidence Reference(s)
product AroL protein nd nd
reactant aroL-yaiA-aroM_mRNA RNA nd nd
shikimate shikimate-3-phosphate
Name: shikimate -> shikimate-3-phosphate
Description: Reaction transforming shikimate into shikimate-3-phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant shikimate simple molecule nd nd
product shikimate-3-phosphate simple molecule nd nd
trpLEDCBA_mRNA TrpB
Name: trpLEDCBA_mRNA -> TrpB
Description: Translation of TrpB
Type: translation
Components:
Function Name Type Evidence Reference(s)
product TrpB protein nd nd
reactant trpLEDCBA_mRNA RNA nd nd
indole-3-glycerol-P + L-serine L-tryptophan + D-glyceraldehyde 3-phosphate
Name: indole-3-glycerol-P + L-serine -> L-tryptophan + D-glyceraldehyde 3-phosphate
Description: Reaction transforming indole-3-glycerol-P, L-serine into L-tryptophan, D-glyceraldehyde 3-phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product D-glyceraldehyde 3-phosphate simple molecule nd nd
reactant L-serine simple molecule nd nd
reactant indole-3-glycerol-P simple molecule nd nd
product L-tryptophan simple molecule nd nd
indole-3-glycerol-P indole + D-glyceraldehyde 3-phosphate
Name: indole-3-glycerol-P -> indole + D-glyceraldehyde 3-phosphate
Description: Reaction transforming indole-3-glycerol-P into indole, D-glyceraldehyde 3-phosphate
Type: state transition
Components:
Function Name Type Evidence Reference(s)
reactant indole-3-glycerol-P simple molecule nd nd
product D-glyceraldehyde 3-phosphate simple molecule nd nd
product indole simple molecule nd nd
indole + L-serine L-tryptophan
Name: indole + L-serine -> L-tryptophan
Description: Reaction transforming indole, L-serine into L-tryptophan
Type: state transition
Components:
Function Name Type Evidence Reference(s)
product L-tryptophan simple molecule nd nd
reactant L-serine simple molecule nd nd
reactant indole simple molecule nd nd
trpLEDCBA_mRNA TrpA
Name: trpLEDCBA_mRNA -> TrpA
Description: Translation of TrpA
Type: translation
Components:
Function Name Type Evidence Reference(s)
product TrpA protein nd nd
reactant trpLEDCBA_mRNA RNA nd nd
shikimate-3-phosphate chorismate
Name: shikimate-3-phosphate -> chorismate
Description: Transformation of shikimate-3-phosphate into chorismate by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
product chorismate simple molecule nd nd
reactant shikimate-3-phosphate simple molecule nd nd
DAHP shikimate
Name: DAHP -> shikimate
Description: Transformation of DAHP into shikimate by one, or two/three reactions not shown.
Type: super-reaction
Components:
Function Name Type Evidence Reference(s)
product shikimate simple molecule nd nd
reactant DAHP simple molecule nd nd
trpL_mRNA TrpL
Name: trpL_mRNA -> TrpL
Description: Translation of TrpL
Type: translation
Components:
Function Name Type Evidence Reference(s)
product TrpL protein nd nd
reactant trpL_mRNA RNA nd nd



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