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TreR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
alpha-trehalose 6-phosphate alpha-trehalose_Ext Crr D-glucopyranose HPr HPr - phosphorylated_Ext TreB TreC TreR Trehalose beta-D-glucose-6-P treBC treBC_mRNA TreR trehalose-6-phosphate TreR Trehalose TreB Crr


Gensor Unit       
Name: TreR
Description: Molecular biology level
Detailed: In the absence of trehalose and trehalose-6-phosphate, TreR negatively regulates the expression of genes required for thehalose catabolic process. Under these conditions, TreR remains unmodified, binds its target sites preventing the expression of its regulated genes.
Less detailed: In the absence of trehalose and trehalose-6-phosphate, TreR negatively regulates the expression of genes needed for trehalose catabolism.

Physiology level
Detailed: The presence of trehalose induces the expression involved with trehalose utilization. Under these conditions the genes necessary for transport and conversion of trehalose-6-phosphate to glucose- 6- phosphate are expressed.
Less detailed: The presence of threhalose induces the expression of genes needful for trehalose-6-phosphate transport and conversion to glucose-6-phosphate.
Classification:
Groups: GUs related to carbon source utilization
Gene Ontology Terms (GO): biological_process GO:0005975 - carbohydrate metabolic process
GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
GO:0006974 - cellular response to DNA damage stimulus
GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0016310 - phosphorylation
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cellular_component GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0008788 - alpha,alpha-phosphotrehalase activity
GO:0003824 - catalytic activity
GO:0016301 - kinase activity
GO:0008982 - protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO:0090563 - protein-phosphocysteine-sugar phosphotransferase activity
GO:0090589 - protein-phosphocysteine-trehalose phosphotransferase system transporter activity
GO:0016740 - transferase activity
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Components: Show/Hide Components Table (16 more...)
Function Name Type
simple_molecule α,α-trehalose 6-phosphate simple_molecule
protein Crr protein
simple_molecule HPr - phosphorylated_Ext simple_molecule
simple_molecule PtsH simple_molecule
protein TreB protein
complex TreB-Crr complex
protein TreC protein
protein TreR protein
complex TreR-α,α-trehalose 6-phosphate complex
complex TreR-trehalose complex
simple_molecule glucopyranose simple_molecule
simple_molecule glucose-6-P simple_molecule
gene treBC gene
RNA treBC_mRNA RNA
simple_molecule trehalose simple_molecule
simple_molecule trehalose_Ext simple_molecule


Reactions       
Showing 8 reactions
TreR treBC treBC_mRNA
Name: treBC -> treBC_mRNA
Description: Transcription of transcription unit treBC. Reaction inhibition by TreR.
Type: transcription
Pathway Components: treBC - TreR -> treBC_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor TreR protein nd nd
reactant treBC gene nd nd
product treBC_mRNA RNA nd nd
trehalose + TreR TreR-trehalose
Name: trehalose + TreR -> TreR-trehalose
Description: Reaction transforming trehalose, TreR into TreR-trehalose
Type: state transition
Pathway Components: trehalose + TreR -> TreR-trehalose
Components:
Function Name Type Evidence Reference(s)
reactant TreR protein nd nd
product TreR-trehalose complex nd nd
reactant trehalose simple_molecule nd nd
α,α-trehalose 6-phosphate + TreR TreR-α,α-trehalose 6-phosphate
Name: α,α-trehalose 6-phosphate + TreR -> TreR-α,α-trehalose 6-phosphate
Description: Reaction transforming α,α-trehalose 6-phosphate, TreR into TreR-α,α-trehalose 6-phosphate
Type: state transition
Pathway Components: α,α-trehalose 6-phosphate + TreR -> TreR-α,α-trehalose 6-phosphate
Components:
Function Name Type Evidence Reference(s)
reactant α,α-trehalose 6-phosphate simple_molecule nd nd
reactant TreR protein nd nd
product TreR-α,α-trehalose 6-phosphate complex nd nd
treBC_mRNA TreB
Name: treBC_mRNA -> TreB
Description: Translation of TreB
Type: translation
Pathway Components: treBC_mRNA -> TreB
Components:
Function Name Type Evidence Reference(s)
product TreB protein nd nd
reactant treBC_mRNA RNA nd nd
TreB + Crr TreB-Crr
Name: TreB + Crr -> TreB-Crr
Description: Reaction transforming TreB, Crr into TreB-Crr
Type: state transition
Pathway Components: TreB + Crr -> TreB-Crr
Components:
Function Name Type Evidence Reference(s)
reactant Crr protein nd nd
reactant TreB protein nd nd
product TreB-Crr complex nd nd
TreB-Crr HPr - phosphorylated_Ext + trehalose_Ext α,α-trehalose 6-phosphate + PtsH
Name: HPr - phosphorylated_Ext + trehalose_Ext -> α,α-trehalose 6-phosphate + PtsH
Description: Transport of HPr - phosphorylated_Ext, trehalose_Ext through a bacterial membrane, leading to the presence of α,α-trehalose 6-phosphate, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + trehalose_Ext - TreB-Crr -> α,α-trehalose 6-phosphate + PtsH
Components:
Function Name Type Evidence Reference(s)
product α,α-trehalose 6-phosphate simple_molecule nd nd
reactant HPr - phosphorylated_Ext simple_molecule nd nd
product PtsH simple_molecule nd nd
catalyzer TreB-Crr complex nd nd
reactant trehalose_Ext simple_molecule nd nd
treBC_mRNA TreC
Name: treBC_mRNA -> TreC
Description: Translation of TreC
Type: translation
Pathway Components: treBC_mRNA -> TreC
Components:
Function Name Type Evidence Reference(s)
product TreC protein nd nd
reactant treBC_mRNA RNA nd nd
TreC α,α-trehalose 6-phosphate glucopyranose + glucose-6-P
Name: α,α-trehalose 6-phosphate -> glucopyranose + glucose-6-P
Description: Reaction transforming α,α-trehalose 6-phosphate into glucopyranose, glucose-6-P
Type: state transition
Pathway Components: α,α-trehalose 6-phosphate - TreC -> glucopyranose + glucose-6-P
Components:
Function Name Type Evidence Reference(s)
reactant α,α-trehalose 6-phosphate simple_molecule nd nd
catalyzer TreC protein nd nd
product glucopyranose simple_molecule nd nd
product glucose-6-P simple_molecule nd nd



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