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TdcA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
2-oxobutyrate L-serine L-serine_Ext thr thr_Ext TdcA TdcB TdcC TdcD TdcE TdcF TdcG ac-CoA ammonia CoA formate propanoate propanoyl-P propanoyl-CoA pyruvate tdcABCDEFG tdcABCDEFG_mRNA


Gensor Unit       
Name: TdcA
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0006565 - L-serine catabolic process
GO:0015825 - L-serine transport
GO:0070689 - L-threonine catabolic process to propionate
GO:0003333 - amino acid transmembrane transport
GO:0006865 - amino acid transport
GO:0019665 - anaerobic amino acid catabolic process
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0043875 - 2-ketobutyrate formate-lyase activity
GO:0003941 - L-serine ammonia-lyase activity
GO:0015194 - L-serine transmembrane transporter activity
GO:0004794 - L-threonine ammonia-lyase activity
GO:0015195 - L-threonine transmembrane transporter activity
GO:0008776 - acetate kinase activity
GO:0016407 - acetyltransferase activity
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Components: Show/Hide Components Table (23 more...)
Function Name Type
simple_molecule (2Z)-2-aminobut-2-enoate simple_molecule
simple_molecule 2-oxobutyrate simple_molecule
protein TdcA protein
protein TdcB protein
protein TdcC protein
protein TdcD protein
protein TdcE protein
protein TdcF protein
protein TdcG protein
simple_molecule acetyl-CoA simple_molecule
simple_molecule coenzyme A simple_molecule
simple_molecule dehydroalanine simple_molecule
simple_molecule formate simple_molecule
simple_molecule propanoate simple_molecule
simple_molecule propanoyl-CoA simple_molecule
simple_molecule propanoyl-P simple_molecule
simple_molecule pyruvate simple_molecule
simple_molecule serine simple_molecule
simple_molecule serine_Ext simple_molecule
gene tdcABCDEFG gene
RNA tdcABCDEFG_mRNA RNA
simple_molecule threonine simple_molecule
simple_molecule threonine_Ext simple_molecule


Reactions       
Showing 17 reactions
TdcA tdcABCDEFG tdcABCDEFG_mRNA
Name: tdcABCDEFG -> tdcABCDEFG_mRNA
Description: Transcription of transcription unit tdcABCDEFG. Reaction activation by TdcA.
Type: transcription
Pathway Components: tdcABCDEFG - TdcA -> tdcABCDEFG_mRNA
Components:
Function Name Type Evidence Reference(s)
activator TdcA protein nd nd
reactant tdcABCDEFG gene nd nd
product tdcABCDEFG_mRNA RNA nd nd
tdcABCDEFG_mRNA TdcA
Name: tdcABCDEFG_mRNA -> TdcA
Description: Translation of TdcA
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcA
Components:
Function Name Type Evidence Reference(s)
product TdcA protein nd nd
reactant tdcABCDEFG_mRNA RNA nd nd
tdcABCDEFG_mRNA TdcB
Name: tdcABCDEFG_mRNA -> TdcB
Description: Translation of TdcB
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcB
Components:
Function Name Type Evidence Reference(s)
product TdcB protein nd nd
reactant tdcABCDEFG_mRNA RNA nd nd
TdcB TdcG serine dehydroalanine
Name: serine -> dehydroalanine
Description: Reaction transforming serine into dehydroalanine
Type: state transition
Pathway Components: serine - TdcB - TdcG -> dehydroalanine
Components:
Function Name Type Evidence Reference(s)
catalyzer TdcB protein nd nd
catalyzer TdcG protein nd nd
product dehydroalanine simple_molecule nd nd
reactant serine simple_molecule nd nd
2-oxobutyrate TdcB pyruvate threonine (2Z)-2-aminobut-2-enoate
Name: threonine -> (2Z)-2-aminobut-2-enoate
Description: Reaction transforming threonine into (2Z)-2-aminobut-2-enoate
Type: state transition
Pathway Components: threonine - TdcB - 2-oxobutyrate - pyruvate -> (2Z)-2-aminobut-2-enoate
Components:
Function Name Type Evidence Reference(s)
product (2Z)-2-aminobut-2-enoate simple_molecule nd nd
inhibitor 2-oxobutyrate simple_molecule nd nd
catalyzer TdcB protein nd nd
inhibitor pyruvate simple_molecule nd nd
reactant threonine simple_molecule nd nd
tdcABCDEFG_mRNA TdcC
Name: tdcABCDEFG_mRNA -> TdcC
Description: Translation of TdcC
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcC
Components:
Function Name Type Evidence Reference(s)
product TdcC protein nd nd
reactant tdcABCDEFG_mRNA RNA nd nd
TdcC serine_Ext serine
Name: serine_Ext -> serine
Description: Transport of serine_Ext through a bacterial membrane, leading to the presence of serine inside the cell.
Type: transport
Pathway Components: serine_Ext - TdcC -> serine
Components:
Function Name Type Evidence Reference(s)
catalyzer TdcC protein nd nd
product serine simple_molecule nd nd
reactant serine_Ext simple_molecule nd nd
TdcC threonine_Ext threonine
Name: threonine_Ext -> threonine
Description: Transport of threonine_Ext through a bacterial membrane, leading to the presence of threonine inside the cell.
Type: transport
Pathway Components: threonine_Ext - TdcC -> threonine
Components:
Function Name Type Evidence Reference(s)
catalyzer TdcC protein nd nd
product threonine simple_molecule nd nd
reactant threonine_Ext simple_molecule nd nd
tdcABCDEFG_mRNA TdcD
Name: tdcABCDEFG_mRNA -> TdcD
Description: Translation of TdcD
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcD
Components:
Function Name Type Evidence Reference(s)
product TdcD protein nd nd
reactant tdcABCDEFG_mRNA RNA nd nd
TdcD propanoate propanoyl-P
Name: propanoate -> propanoyl-P
Description: Reaction transforming propanoate into propanoyl-P
Type: state transition
Pathway Components: propanoate - TdcD -> propanoyl-P
Components:
Function Name Type Evidence Reference(s)
catalyzer TdcD protein nd nd
reactant propanoate simple_molecule nd nd
product propanoyl-P simple_molecule nd nd
tdcABCDEFG_mRNA TdcE
Name: tdcABCDEFG_mRNA -> TdcE
Description: Translation of TdcE
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcE
Components:
Function Name Type Evidence Reference(s)
product TdcE protein nd nd
reactant tdcABCDEFG_mRNA RNA nd nd
TdcE 2-oxobutyrate + coenzyme A propanoyl-CoA + formate
Name: 2-oxobutyrate + coenzyme A -> propanoyl-CoA + formate
Description: Reaction transforming 2-oxobutyrate, coenzyme A into propanoyl-CoA, formate
Type: state transition
Pathway Components: 2-oxobutyrate + coenzyme A - TdcE -> propanoyl-CoA + formate
Components:
Function Name Type Evidence Reference(s)
reactant 2-oxobutyrate simple_molecule nd nd
catalyzer TdcE protein nd nd
reactant coenzyme A simple_molecule nd nd
product formate simple_molecule nd nd
product propanoyl-CoA simple_molecule nd nd
TdcE coenzyme A + pyruvate acetyl-CoA + formate
Name: coenzyme A + pyruvate -> acetyl-CoA + formate
Description: Reaction transforming coenzyme A, pyruvate into acetyl-CoA, formate
Type: state transition
Pathway Components: coenzyme A + pyruvate - TdcE -> acetyl-CoA + formate
Components:
Function Name Type Evidence Reference(s)
catalyzer TdcE protein nd nd
product acetyl-CoA simple_molecule nd nd
reactant coenzyme A simple_molecule nd nd
product formate simple_molecule nd nd
reactant pyruvate simple_molecule nd nd
tdcABCDEFG_mRNA TdcF
Name: tdcABCDEFG_mRNA -> TdcF
Description: Translation of TdcF
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcF
Components:
Function Name Type Evidence Reference(s)
product TdcF protein nd nd
reactant tdcABCDEFG_mRNA RNA nd nd
tdcABCDEFG_mRNA TdcG
Name: tdcABCDEFG_mRNA -> TdcG
Description: Translation of TdcG
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcG
Components:
Function Name Type Evidence Reference(s)
product TdcG protein nd nd
reactant tdcABCDEFG_mRNA RNA nd nd
(2Z)-2-aminobut-2-enoate 2-oxobutyrate
Name: (2Z)-2-aminobut-2-enoate -> 2-oxobutyrate
Description: Transformation of (2Z)-2-aminobut-2-enoate into 2-oxobutyrate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: (2Z)-2-aminobut-2-enoate / RXN-15123 / 2-oxobutyrate
Components:
Function Name Type Evidence Reference(s)
reactant (2Z)-2-aminobut-2-enoate simple_molecule nd nd
product 2-oxobutyrate simple_molecule nd nd
propanoyl-CoA propanoyl-P
Name: propanoyl-CoA -> propanoyl-P
Description: Transformation of propanoyl-CoA into propanoyl-P by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: propanoyl-CoA / PTAALT-RXN / propanoyl-P
Components:
Function Name Type Evidence Reference(s)
reactant propanoyl-CoA simple_molecule nd nd
product propanoyl-P simple_molecule nd nd



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