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TdcA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
threonine_Ext serine dehydroalanine coenzyme A acetyl-CoA TdcG threonine (2Z)-2-aminobut-2-enoate TdcB pyruvate formate TdcE TdcD propanoate TdcF tdcABCDEFG propanoyl-P ammonium TdcC serine_Ext TdcA 2-oxobutyrate tdcABCDEFG_mRNA propanoyl-CoA


Gensor Unit       
Name: TdcA
Classification:
Groups: Transcription
Energy production and conversion
Amino acid transport and metabolism
Defense mechanisms
Gene Ontology Terms (GO): biological_process GO:0006565 - L-serine catabolic process
GO:0015825 - L-serine transport
GO:0070689 - L-threonine catabolic process to propionate
GO:0003333 - amino acid transmembrane transport
GO:0006865 - amino acid transport
GO:0019665 - anaerobic amino acid catabolic process
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0005622 - intracellular anatomical structure
GO:0016020 - membrane
GO:0005886 - plasma membrane
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molecular_function GO:0043875 - 2-ketobutyrate formate-lyase activity
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0003941 - L-serine ammonia-lyase activity
GO:0015194 - L-serine transmembrane transporter activity
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Components:
  Function Name Type
  simple_molecule (2Z)-2-aminobut-2-enoate simple_molecule
  simple_molecule 2-oxobutyrate simple_molecule
  protein TdcA protein
  protein TdcB protein
  protein TdcC protein
  protein TdcD protein
  protein TdcE protein
  protein TdcF protein
  protein TdcG protein
  simple_molecule acetyl-CoA simple_molecule
  simple_molecule ammonium simple_molecule
  simple_molecule coenzyme A simple_molecule
  simple_molecule dehydroalanine simple_molecule
  simple_molecule formate simple_molecule
  simple_molecule propanoate simple_molecule
  simple_molecule propanoyl-CoA simple_molecule
  simple_molecule propanoyl-P simple_molecule
  simple_molecule pyruvate simple_molecule
  simple_molecule serine simple_molecule
  simple_molecule serine_Ext simple_molecule
  gene tdcABCDEFG gene
  RNA tdcABCDEFG_mRNA RNA
  simple_molecule threonine simple_molecule
  simple_molecule threonine_Ext simple_molecule


Reactions       
Showing 19 reactions
TdcA tdcABCDEFG tdcABCDEFG_mRNA
Name: tdcABCDEFG -> tdcABCDEFG_mRNA
Description: Transcription of transcription unit tdcABCDEFG. Reaction activation by TdcA.
Type: transcription
Pathway Components: tdcABCDEFG - TdcA -> tdcABCDEFG_mRNA
Components:
Function Name Type
activator TdcA protein
reactant tdcABCDEFG gene
product tdcABCDEFG_mRNA RNA
tdcABCDEFG_mRNA TdcA
Name: tdcABCDEFG_mRNA -> TdcA
Description: Translation of TdcA
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcA
Components:
Function Name Type
product TdcA protein
reactant tdcABCDEFG_mRNA RNA
tdcABCDEFG_mRNA TdcB
Name: tdcABCDEFG_mRNA -> TdcB
Description: Translation of TdcB
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcB
Components:
Function Name Type
product TdcB protein
reactant tdcABCDEFG_mRNA RNA
TdcB TdcG serine ammonium + pyruvate
Name: serine -> ammonium + pyruvate
Description: Reaction transforming serine into ammonium, pyruvate
Type: state transition
Pathway Components: serine - TdcB - TdcG -> ammonium + pyruvate
Components:
Function Name Type
catalyzer TdcB protein
catalyzer TdcG protein
product ammonium simple_molecule
product pyruvate simple_molecule
reactant serine simple_molecule
TdcB TdcG serine dehydroalanine
Name: serine -> dehydroalanine
Description: Reaction transforming serine into dehydroalanine
Type: state transition
Pathway Components: serine - TdcB - TdcG -> dehydroalanine
Components:
Function Name Type
catalyzer TdcB protein
catalyzer TdcG protein
product dehydroalanine simple_molecule
reactant serine simple_molecule
2-oxobutyrate TdcB pyruvate threonine 2-oxobutyrate + ammonium
Name: threonine -> 2-oxobutyrate + ammonium
Description: Reaction transforming threonine into 2-oxobutyrate, ammonium
Type: state transition
Pathway Components: threonine - TdcB - 2-oxobutyrate - pyruvate -> 2-oxobutyrate + ammonium
Components:
Function Name Type
inhibitor 2-oxobutyrate simple_molecule
product 2-oxobutyrate simple_molecule
catalyzer TdcB protein
product ammonium simple_molecule
inhibitor pyruvate simple_molecule
reactant threonine simple_molecule
TdcB threonine (2Z)-2-aminobut-2-enoate
Name: threonine -> (2Z)-2-aminobut-2-enoate
Description: Reaction transforming threonine into (2Z)-2-aminobut-2-enoate
Type: state transition
Pathway Components: threonine - TdcB -> (2Z)-2-aminobut-2-enoate
Components:
Function Name Type
product (2Z)-2-aminobut-2-enoate simple_molecule
catalyzer TdcB protein
reactant threonine simple_molecule
tdcABCDEFG_mRNA TdcC
Name: tdcABCDEFG_mRNA -> TdcC
Description: Translation of TdcC
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcC
Components:
Function Name Type
product TdcC protein
reactant tdcABCDEFG_mRNA RNA
TdcC serine_Ext serine
Name: serine_Ext -> serine
Description: Transport of serine_Ext through a bacterial membrane, leading to the presence of serine inside the cell.
Type: transport
Pathway Components: serine_Ext - TdcC -> serine
Components:
Function Name Type
catalyzer TdcC protein
product serine simple_molecule
reactant serine_Ext simple_molecule
TdcC threonine_Ext threonine
Name: threonine_Ext -> threonine
Description: Transport of threonine_Ext through a bacterial membrane, leading to the presence of threonine inside the cell.
Type: transport
Pathway Components: threonine_Ext - TdcC -> threonine
Components:
Function Name Type
catalyzer TdcC protein
product threonine simple_molecule
reactant threonine_Ext simple_molecule
tdcABCDEFG_mRNA TdcD
Name: tdcABCDEFG_mRNA -> TdcD
Description: Translation of TdcD
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcD
Components:
Function Name Type
product TdcD protein
reactant tdcABCDEFG_mRNA RNA
TdcD propanoate propanoyl-P
Name: propanoate -> propanoyl-P
Description: Reaction transforming propanoate into propanoyl-P
Type: state transition
Pathway Components: propanoate - TdcD -> propanoyl-P
Components:
Function Name Type
catalyzer TdcD protein
reactant propanoate simple_molecule
product propanoyl-P simple_molecule
tdcABCDEFG_mRNA TdcE
Name: tdcABCDEFG_mRNA -> TdcE
Description: Translation of TdcE
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcE
Components:
Function Name Type
product TdcE protein
reactant tdcABCDEFG_mRNA RNA
TdcE 2-oxobutyrate + coenzyme A propanoyl-CoA + formate
Name: 2-oxobutyrate + coenzyme A -> propanoyl-CoA + formate
Description: Reaction transforming 2-oxobutyrate, coenzyme A into propanoyl-CoA, formate
Type: state transition
Pathway Components: 2-oxobutyrate + coenzyme A - TdcE -> propanoyl-CoA + formate
Components:
Function Name Type
reactant 2-oxobutyrate simple_molecule
catalyzer TdcE protein
reactant coenzyme A simple_molecule
product formate simple_molecule
product propanoyl-CoA simple_molecule
TdcE coenzyme A + pyruvate acetyl-CoA + formate
Name: coenzyme A + pyruvate -> acetyl-CoA + formate
Description: Reaction transforming coenzyme A, pyruvate into acetyl-CoA, formate
Type: state transition
Pathway Components: coenzyme A + pyruvate - TdcE -> acetyl-CoA + formate
Components:
Function Name Type
catalyzer TdcE protein
product acetyl-CoA simple_molecule
reactant coenzyme A simple_molecule
product formate simple_molecule
reactant pyruvate simple_molecule
tdcABCDEFG_mRNA TdcF
Name: tdcABCDEFG_mRNA -> TdcF
Description: Translation of TdcF
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcF
Components:
Function Name Type
product TdcF protein
reactant tdcABCDEFG_mRNA RNA
tdcABCDEFG_mRNA TdcG
Name: tdcABCDEFG_mRNA -> TdcG
Description: Translation of TdcG
Type: translation
Pathway Components: tdcABCDEFG_mRNA -> TdcG
Components:
Function Name Type
product TdcG protein
reactant tdcABCDEFG_mRNA RNA
(2Z)-2-aminobut-2-enoate 2-oxobutyrate
Name: (2Z)-2-aminobut-2-enoate -> 2-oxobutyrate
Description: Transformation of (2Z)-2-aminobut-2-enoate into 2-oxobutyrate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: (2Z)-2-aminobut-2-enoate / RXN-15123 / 2-oxobutyrate
Components:
Function Name Type
reactant (2Z)-2-aminobut-2-enoate simple_molecule
product 2-oxobutyrate simple_molecule
propanoyl-CoA propanoyl-P
Name: propanoyl-CoA -> propanoyl-P
Description: Transformation of propanoyl-CoA into propanoyl-P by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: propanoyl-CoA / PTAALT-RXN / propanoyl-P
Components:
Function Name Type
reactant propanoyl-CoA simple_molecule
product propanoyl-P simple_molecule



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