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SoxR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          


Gensor Unit       
Name: SoxR
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0006106 - fumarate metabolic process
GO:0006108 - malate metabolic process
GO:0006355 - regulation of transcription, DNA-templated
GO:0006979 - response to oxidative stress
GO:0006099 - tricarboxylic acid cycle
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0001108 - bacterial-type RNA polymerase holo enzyme binding
GO:0000986 - bacterial-type proximal promoter sequence-specific DNA binding
GO:0004333 - fumarate hydratase activity
Components: Show/Hide Components Table (20 more...)
Function Name Type
protein FumA protein
protein FumC protein
protein SoxR protein
complex SoxR-[2Fe-2S]2+ reduced complex
complex SoxR-[2Fe-2S]3+ oxidized complex
protein SoxS protein
simple_molecule [2Fe-2S]2+ reduced simple_molecule
simple_molecule [2Fe-2S]3+ oxidized simple_molecule
simple_molecule enol-oxaloacetate simple_molecule
gene fumAC gene
RNA fumAC_mRNA RNA
gene fumC gene
RNA fumC_mRNA RNA
simple_molecule fumarate simple_molecule
simple_molecule malate simple_molecule
simple_molecule oxalacetate simple_molecule
gene soxR gene
RNA soxR_mRNA RNA
gene soxS gene
RNA soxS_mRNA RNA


Reactions       
Showing 13 reactions
[2Fe-2S]3+ oxidized + SoxR SoxR-[2Fe-2S]3+ oxidized
Name: [2Fe-2S]3+ oxidized + SoxR -> SoxR-[2Fe-2S]3+ oxidized
Description: Reaction transforming [2Fe-2S]3+ oxidized, SoxR into SoxR-[2Fe-2S]3+ oxidized
Type: state transition
Pathway Components: [2Fe-2S]3+ oxidized + SoxR -> SoxR-[2Fe-2S]3+ oxidized
Components:
Function Name Type Evidence Reference(s)
reactant SoxR protein nd nd
product SoxR-[2Fe-2S]3+ oxidized complex nd nd
reactant [2Fe-2S]3+ oxidized simple_molecule nd nd
SoxR-[2Fe-2S]3+ oxidized fumAC fumAC_mRNA
Name: fumAC -> fumAC_mRNA
Description: Transcription of transcription unit fumAC. Reaction activation by SoxR-[2Fe-2S]3+ oxidized.
Type: transcription
Pathway Components: fumAC - SoxR-[2Fe-2S]3+ oxidized -> fumAC_mRNA
Components:
Function Name Type Evidence Reference(s)
activator SoxR-[2Fe-2S]3+ oxidized complex nd nd
reactant fumAC gene nd nd
product fumAC_mRNA RNA nd nd
SoxR-[2Fe-2S]3+ oxidized soxS soxS_mRNA
Name: soxS -> soxS_mRNA
Description: Transcription of transcription unit soxS. Reaction activation by SoxR-[2Fe-2S]3+ oxidized.
Type: transcription
Pathway Components: soxS - SoxR-[2Fe-2S]3+ oxidized -> soxS_mRNA
Components:
Function Name Type Evidence Reference(s)
activator SoxR-[2Fe-2S]3+ oxidized complex nd nd
reactant soxS gene nd nd
product soxS_mRNA RNA nd nd
SoxR-[2Fe-2S]3+ oxidized soxR soxR_mRNA
Name: soxR -> soxR_mRNA
Description: Transcription of transcription unit soxR. Reaction inhibition by SoxR-[2Fe-2S]3+ oxidized.
Type: transcription
Pathway Components: soxR - SoxR-[2Fe-2S]3+ oxidized -> soxR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor SoxR-[2Fe-2S]3+ oxidized complex nd nd
reactant soxR gene nd nd
product soxR_mRNA RNA nd nd
[2Fe-2S]2+ reduced + SoxR SoxR-[2Fe-2S]2+ reduced
Name: [2Fe-2S]2+ reduced + SoxR -> SoxR-[2Fe-2S]2+ reduced
Description: Reaction transforming [2Fe-2S]2+ reduced, SoxR into SoxR-[2Fe-2S]2+ reduced
Type: state transition
Pathway Components: [2Fe-2S]2+ reduced + SoxR -> SoxR-[2Fe-2S]2+ reduced
Components:
Function Name Type Evidence Reference(s)
reactant SoxR protein nd nd
product SoxR-[2Fe-2S]2+ reduced complex nd nd
reactant [2Fe-2S]2+ reduced simple_molecule nd nd
SoxR fumC fumC_mRNA
Name: fumC -> fumC_mRNA
Description: Transcription of transcription unit fumC. Reaction activation by SoxR.
Type: transcription
Pathway Components: fumC - SoxR -> fumC_mRNA
Components:
Function Name Type Evidence Reference(s)
activator SoxR protein nd nd
reactant fumC gene nd nd
product fumC_mRNA RNA nd nd
fumAC_mRNA FumA
Name: fumAC_mRNA -> FumA
Description: Translation of FumA
Type: translation
Pathway Components: fumAC_mRNA -> FumA
Components:
Function Name Type Evidence Reference(s)
product FumA protein nd nd
reactant fumAC_mRNA RNA nd nd
FumA FumC malate fumarate
Name: malate -> fumarate
Description: Reaction transforming malate into fumarate
Type: state transition
Pathway Components: malate - FumA - FumC -> fumarate
Components:
Function Name Type Evidence Reference(s)
catalyzer FumA protein nd nd
catalyzer FumC protein nd nd
product fumarate simple_molecule nd nd
reactant malate simple_molecule nd nd
FumA oxalacetate enol-oxaloacetate
Name: oxalacetate -> enol-oxaloacetate
Description: Reaction transforming oxalacetate into enol-oxaloacetate
Type: state transition
Pathway Components: oxalacetate - FumA -> enol-oxaloacetate
Components:
Function Name Type Evidence Reference(s)
catalyzer FumA protein nd nd
product enol-oxaloacetate simple_molecule nd nd
reactant oxalacetate simple_molecule nd nd
fumAC_mRNA FumC
Name: fumAC_mRNA -> FumC
Description: Translation of FumC
Type: translation
Pathway Components: fumAC_mRNA -> FumC
Components:
Function Name Type Evidence Reference(s)
product FumC protein nd nd
reactant fumAC_mRNA RNA nd nd
soxR_mRNA SoxR
Name: soxR_mRNA -> SoxR
Description: Translation of SoxR
Type: translation
Pathway Components: soxR_mRNA -> SoxR
Components:
Function Name Type Evidence Reference(s)
product SoxR protein nd nd
reactant soxR_mRNA RNA nd nd
soxS_mRNA SoxS
Name: soxS_mRNA -> SoxS
Description: Translation of SoxS
Type: translation
Pathway Components: soxS_mRNA -> SoxS
Components:
Function Name Type Evidence Reference(s)
product SoxS protein nd nd
reactant soxS_mRNA RNA nd nd
fumC_mRNA FumC
Name: fumC_mRNA -> FumC
Description: Translation of FumC
Type: translation
Pathway Components: fumC_mRNA -> FumC
Components:
Function Name Type Evidence Reference(s)
product FumC protein nd nd
reactant fumC_mRNA RNA nd nd



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