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RhaS Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
L-lactaldehyde L-rhamnose L-rhamnose_Ext L-rhamnulose L-rhamnulose-1-phosphate D-xylulose RhaA RhaB RhaD RhaR RhaS RhaT beta-L-lyxose beta-L-lyxose_Ext DHAP rhaBAD rhaBAD_mRNA rhaSR rhaSR_mRNA rhaT rhaT_mRNA RhaS L-rhamnose


Gensor Unit       
Name: RhaS
Description: Molecular biology level
Detailed: In the presence of L-rhamnose, RhaS positively regulates the expression of genes required for rhamnose and lyxose transport and catabolic processes and its own expression. Under these conditions, RhaS is modified to RhaS-L-rhamnose, binds its targes sites enabling its own expression and the expression of itrs regulated genes. In the absence of L-rhamnose, RhaS unbinds its target sites preventing the expression of its regulated genes.
Less detailed: In the presence of L-rhamnose, RhaS positively regulates the expression of genes needed for rhamnose and lyxose transport and catabolic processes.

Physiology level
Detailed: The presence of L-rhamnose induces the expression of genes involved with rhamnose and lyxose catabolic processes. Under these conditions, the genes necessary for lyxose isomerization to D-xylulose and conversion of L-rhamnose to dihidroxyacetone-phosphate and L-lactaldehyde are expressed.
Less detailed: The presence of L-rhamnose induces the expression of genes needful for lyxose isomerization to D-xylulose and conversion of L-rhamnose to dihidroxyacetone-phosphate and L-lactaldehyde.
Classification:
Groups: Unclassified Gensor Units
Gene Ontology Terms (GO): biological_process GO:0019324 - L-lyxose metabolic process
GO:0046835 - carbohydrate phosphorylation
GO:0019243 - methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
GO:0019323 - pentose catabolic process
GO:0006355 - regulation of transcription, DNA-templated
GO:0019301 - rhamnose catabolic process
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cellular_component GO:0005829 - cytosol
GO:0005886 - plasma membrane
molecular_function GO:0005524 - ATP binding
GO:0003700 - DNA binding transcription factor activity
GO:0008740 - L-rhamnose isomerase activity
GO:0016832 - aldehyde-lyase activity
GO:0019172 - glyoxalase III activity
GO:0042802 - identical protein binding
GO:0008993 - rhamnulokinase activity
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Components: Show/Hide Components Table (24 more...)
Function Name Type
simple_molecule DHAP simple_molecule
protein RhaA protein
protein RhaB protein
protein RhaD protein
protein RhaR protein
protein RhaS protein
complex RhaS-rhamnose complex
protein RhaT protein
simple_molecule beta-L-lyxose simple_molecule
simple_molecule beta-L-lyxose_Ext simple_molecule
simple_molecule beta-L-rhamnopyranose simple_molecule
simple_molecule keto-L-rhamnulose simple_molecule
simple_molecule lactaldehyde simple_molecule
gene rhaBAD gene
RNA rhaBAD_mRNA RNA
gene rhaSR gene
RNA rhaSR_mRNA RNA
gene rhaT gene
RNA rhaT_mRNA RNA
simple_molecule rhamnose simple_molecule
simple_molecule rhamnose_Ext simple_molecule
simple_molecule rhamnulofuranose simple_molecule
simple_molecule rhamnulose-1P simple_molecule
simple_molecule xylulose simple_molecule


Reactions       
Showing 17 reactions
rhamnose + RhaS RhaS-rhamnose
Name: rhamnose + RhaS -> RhaS-rhamnose
Description: Reaction transforming rhamnose, RhaS into RhaS-rhamnose
Type: state transition
Pathway Components: rhamnose + RhaS -> RhaS-rhamnose
Components:
Function Name Type Evidence Reference(s)
reactant RhaS protein nd nd
product RhaS-rhamnose complex nd nd
reactant rhamnose simple_molecule nd nd
RhaS-rhamnose rhaBAD rhaBAD_mRNA
Name: rhaBAD -> rhaBAD_mRNA
Description: Transcription of transcription unit rhaBAD. Reaction activation by RhaS-rhamnose.
Type: transcription
Pathway Components: rhaBAD - RhaS-rhamnose -> rhaBAD_mRNA
Components:
Function Name Type Evidence Reference(s)
activator RhaS-rhamnose complex nd nd
reactant rhaBAD gene nd nd
product rhaBAD_mRNA RNA nd nd
RhaS-rhamnose rhaSR rhaSR_mRNA
Name: rhaSR -> rhaSR_mRNA
Description: Transcription of transcription unit rhaSR. Reaction activation by RhaS-rhamnose.
Type: transcription
Pathway Components: rhaSR - RhaS-rhamnose -> rhaSR_mRNA
Components:
Function Name Type Evidence Reference(s)
activator RhaS-rhamnose complex nd nd
reactant rhaSR gene nd nd
product rhaSR_mRNA RNA nd nd
RhaS-rhamnose rhaT rhaT_mRNA
Name: rhaT -> rhaT_mRNA
Description: Transcription of transcription unit rhaT. Reaction activation by RhaS-rhamnose.
Type: transcription
Pathway Components: rhaT - RhaS-rhamnose -> rhaT_mRNA
Components:
Function Name Type Evidence Reference(s)
activator RhaS-rhamnose complex nd nd
reactant rhaT gene nd nd
product rhaT_mRNA RNA nd nd
rhaBAD_mRNA RhaB
Name: rhaBAD_mRNA -> RhaB
Description: Translation of RhaB
Type: translation
Pathway Components: rhaBAD_mRNA -> RhaB
Components:
Function Name Type Evidence Reference(s)
product RhaB protein nd nd
reactant rhaBAD_mRNA RNA nd nd
RhaB rhamnulofuranose rhamnulose-1P
Name: rhamnulofuranose -> rhamnulose-1P
Description: Reaction transforming rhamnulofuranose into rhamnulose-1P
Type: state transition
Pathway Components: rhamnulofuranose - RhaB -> rhamnulose-1P
Components:
Function Name Type Evidence Reference(s)
catalyzer RhaB protein nd nd
reactant rhamnulofuranose simple_molecule nd nd
product rhamnulose-1P simple_molecule nd nd
rhaBAD_mRNA RhaA
Name: rhaBAD_mRNA -> RhaA
Description: Translation of RhaA
Type: translation
Pathway Components: rhaBAD_mRNA -> RhaA
Components:
Function Name Type Evidence Reference(s)
product RhaA protein nd nd
reactant rhaBAD_mRNA RNA nd nd
RhaA beta-L-rhamnopyranose keto-L-rhamnulose
Name: beta-L-rhamnopyranose -> keto-L-rhamnulose
Description: Reaction transforming beta-L-rhamnopyranose into keto-L-rhamnulose
Type: state transition
Pathway Components: beta-L-rhamnopyranose - RhaA -> keto-L-rhamnulose
Components:
Function Name Type Evidence Reference(s)
catalyzer RhaA protein nd nd
reactant beta-L-rhamnopyranose simple_molecule nd nd
product keto-L-rhamnulose simple_molecule nd nd
RhaA beta-L-lyxose xylulose
Name: beta-L-lyxose -> xylulose
Description: Reaction transforming beta-L-lyxose into xylulose
Type: state transition
Pathway Components: beta-L-lyxose - RhaA -> xylulose
Components:
Function Name Type Evidence Reference(s)
catalyzer RhaA protein nd nd
reactant beta-L-lyxose simple_molecule nd nd
product xylulose simple_molecule nd nd
rhaBAD_mRNA RhaD
Name: rhaBAD_mRNA -> RhaD
Description: Translation of RhaD
Type: translation
Pathway Components: rhaBAD_mRNA -> RhaD
Components:
Function Name Type Evidence Reference(s)
product RhaD protein nd nd
reactant rhaBAD_mRNA RNA nd nd
RhaD rhamnulose-1P lactaldehyde + DHAP
Name: rhamnulose-1P -> lactaldehyde + DHAP
Description: Reaction transforming rhamnulose-1P into lactaldehyde, DHAP
Type: state transition
Pathway Components: rhamnulose-1P - RhaD -> lactaldehyde + DHAP
Components:
Function Name Type Evidence Reference(s)
product DHAP simple_molecule nd nd
catalyzer RhaD protein nd nd
product lactaldehyde simple_molecule nd nd
reactant rhamnulose-1P simple_molecule nd nd
rhaSR_mRNA RhaS
Name: rhaSR_mRNA -> RhaS
Description: Translation of RhaS
Type: translation
Pathway Components: rhaSR_mRNA -> RhaS
Components:
Function Name Type Evidence Reference(s)
product RhaS protein nd nd
reactant rhaSR_mRNA RNA nd nd
rhaSR_mRNA RhaR
Name: rhaSR_mRNA -> RhaR
Description: Translation of RhaR
Type: translation
Pathway Components: rhaSR_mRNA -> RhaR
Components:
Function Name Type Evidence Reference(s)
product RhaR protein nd nd
reactant rhaSR_mRNA RNA nd nd
rhaT_mRNA RhaT
Name: rhaT_mRNA -> RhaT
Description: Translation of RhaT
Type: translation
Pathway Components: rhaT_mRNA -> RhaT
Components:
Function Name Type Evidence Reference(s)
product RhaT protein nd nd
reactant rhaT_mRNA RNA nd nd
RhaT beta-L-lyxose_Ext beta-L-lyxose
Name: beta-L-lyxose_Ext -> beta-L-lyxose
Description: Transport of beta-L-lyxose_Ext through a bacterial membrane, leading to the presence of beta-L-lyxose inside the cell.
Type: transport
Pathway Components: beta-L-lyxose_Ext - RhaT -> beta-L-lyxose
Components:
Function Name Type Evidence Reference(s)
catalyzer RhaT protein nd nd
product beta-L-lyxose simple_molecule nd nd
reactant beta-L-lyxose_Ext simple_molecule nd nd
RhaT rhamnose_Ext rhamnose
Name: rhamnose_Ext -> rhamnose
Description: Transport of rhamnose_Ext through a bacterial membrane, leading to the presence of rhamnose inside the cell.
Type: transport
Pathway Components: rhamnose_Ext - RhaT -> rhamnose
Components:
Function Name Type Evidence Reference(s)
catalyzer RhaT protein nd nd
product rhamnose simple_molecule nd nd
reactant rhamnose_Ext simple_molecule nd nd
keto-L-rhamnulose rhamnulofuranose
Name: keto-L-rhamnulose -> rhamnulofuranose
Description: Transformation of keto-L-rhamnulose into rhamnulofuranose by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: keto-L-rhamnulose / RXN-15356 / rhamnulofuranose
Components:
Function Name Type Evidence Reference(s)
reactant keto-L-rhamnulose simple_molecule nd nd
product rhamnulofuranose simple_molecule nd nd



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