RegulonDB RegulonDB

RbsR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
10-formyl-tetrahydrofolate 2'-deoxyadenosine 2'-deoxyinosine AICAR FAICAR PRA Add ribose ribose-5P Imp GAR PurD PurH RbsA RbsB RbsC RbsD RbsK RbsR add add_mRNA adenosine alpha D-ribose ammonium beta-D-ribofuranose beta-D-ribopyranose beta-D-ribopyranose_Ext glycine inosine phosphate purHD purHD_mRNA rbsDACBKR rbsDACBKR_mRNA THF RbsR ribose RbsA RbsC RbsB phosphate


Gensor Unit       
Name: RbsR
Description: Molecular biology level
Detailed: In the presence of ribose, RbsR positively regulates the expression of genes required for adenosine catabolic process. Under these conditions, RbsR is modified to RbsR-ribose, binds its target sites enabling the expression of its regulated genes. RbsR negatively regulates its own expression and the expression of genes required for ribose catabolism and purine biosynthesis in the absence of ribose. Under these conditions, RbsR binds its target sites preventing the expression of its regulated genes.
Less detailed: In the presence of ribose RbsR positively regulates the expression of genes needed for adenosine catabolic process. RbsR negatively regulates the expression of genes involved in ribose catabolism and purine biosynthesis in the absence of ribose.

Physiology level
Detailed: The presence of ribose induces the expression of genes involved with adenosine catabolism. Under these conditions the genes necessary for degradation of adenosine to ammonium are expressed. The absence of ribose inhibits the expression of genes required for ribose catabolism and purine biosynthesis. Under this condition, the genes necessary for transport of ribose and and its conversion from furan to pyran form are not expressed; and the genes necessary for conversion of PRA (5-phosphoribosylamine) to GAR ( 5'-phosphoribosylglycinamide), and AICAR (5-amino-1-beta-D-ribofuranosyl-, 5-(dihydrogen phosphate)) to FAICAR (5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide), are not expressed.
Less detailed: Read more >
Classification:
Groups: GUs related to carbon source utilization
Gene Ontology Terms (GO): biological_process GO:0019303 - D-ribose catabolic process
GO:0015752 - D-ribose transmembrane transport
GO:0006154 - adenosine catabolic process
GO:0046835 - carbohydrate phosphorylation
GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
Read more >
cellular_component GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
Read more >
molecular_function GO:0005524 - ATP binding
GO:0042623 - ATPase activity, coupled
GO:0015591 - D-ribose transmembrane transporter activity
GO:0003677 - DNA binding
GO:0003937 - IMP cyclohydrolase activity
GO:0004000 - adenosine deaminase activity
GO:0001216 - bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Read more >
Components: Show/Hide Components Table (37 more...)
Function Name Type
simple_molecule α D-ribose simple_molecule
simple_molecule α-D-ribose 5-phosphate simple_molecule
simple_molecule 10-formyl-THF mono-L-glutamate simple_molecule
simple_molecule 5'-IMP simple_molecule
simple_molecule 5'-p-ribosylglycinamide simple_molecule
simple_molecule 5-phosphoribosylamine simple_molecule
simple_molecule AICAR simple_molecule
protein Add protein
simple_molecule FAICAR simple_molecule
protein PurD protein
protein PurH protein
protein RbsA protein
complex RbsA-RbsC-RbsB complex
protein RbsB protein
protein RbsC protein
protein RbsD protein
protein RbsK protein
protein RbsR protein
complex RbsR-ribose complex
simple_molecule THF polyglutamate simple_molecule
gene add gene
RNA add_mRNA RNA
simple_molecule adenosine simple_molecule
simple_molecule ammonium simple_molecule
simple_molecule beta-D-ribofuranose simple_molecule
simple_molecule beta-D-ribopyranose simple_molecule
simple_molecule beta-D-ribopyranose_Ext simple_molecule
simple_molecule deoxyadenosine simple_molecule
simple_molecule deoxyinosine simple_molecule
simple_molecule glycine simple_molecule
simple_molecule inosine simple_molecule
simple_molecule phosphate simple_molecule
gene purHD gene
RNA purHD_mRNA RNA
gene rbsDACBKR gene
RNA rbsDACBKR_mRNA RNA
simple_molecule ribose simple_molecule


Reactions       
Showing 24 reactions
RbsR add add_mRNA
Name: add -> add_mRNA
Description: Transcription of transcription unit add. Reaction activation by RbsR.
Type: transcription
Pathway Components: add - RbsR -> add_mRNA
Components:
Function Name Type Evidence Reference(s)
activator RbsR protein nd nd
reactant add gene nd nd
product add_mRNA RNA nd nd
RbsR purHD purHD_mRNA
Name: purHD -> purHD_mRNA
Description: Transcription of transcription unit purHD. Reaction inhibition by RbsR.
Type: transcription
Pathway Components: purHD - RbsR -> purHD_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor RbsR protein nd nd
reactant purHD gene nd nd
product purHD_mRNA RNA nd nd
RbsR rbsDACBKR rbsDACBKR_mRNA
Name: rbsDACBKR -> rbsDACBKR_mRNA
Description: Transcription of transcription unit rbsDACBKR. Reaction inhibition by RbsR.
Type: transcription
Pathway Components: rbsDACBKR - RbsR -> rbsDACBKR_mRNA
Components:
Function Name Type Evidence Reference(s)
inhibitor RbsR protein nd nd
reactant rbsDACBKR gene nd nd
product rbsDACBKR_mRNA RNA nd nd
ribose + RbsR RbsR-ribose
Name: ribose + RbsR -> RbsR-ribose
Description: Reaction transforming ribose, RbsR into RbsR-ribose
Type: state transition
Pathway Components: ribose + RbsR -> RbsR-ribose
Components:
Function Name Type Evidence Reference(s)
reactant RbsR protein nd nd
product RbsR-ribose complex nd nd
reactant ribose simple_molecule nd nd
rbsDACBKR_mRNA RbsD
Name: rbsDACBKR_mRNA -> RbsD
Description: Translation of RbsD
Type: translation
Pathway Components: rbsDACBKR_mRNA -> RbsD
Components:
Function Name Type Evidence Reference(s)
product RbsD protein nd nd
reactant rbsDACBKR_mRNA RNA nd nd
RbsD beta-D-ribopyranose beta-D-ribofuranose
Name: beta-D-ribopyranose -> beta-D-ribofuranose
Description: Reaction transforming beta-D-ribopyranose into beta-D-ribofuranose
Type: state transition
Pathway Components: beta-D-ribopyranose - RbsD -> beta-D-ribofuranose
Components:
Function Name Type Evidence Reference(s)
catalyzer RbsD protein nd nd
product beta-D-ribofuranose simple_molecule nd nd
reactant beta-D-ribopyranose simple_molecule nd nd
rbsDACBKR_mRNA RbsA
Name: rbsDACBKR_mRNA -> RbsA
Description: Translation of RbsA
Type: translation
Pathway Components: rbsDACBKR_mRNA -> RbsA
Components:
Function Name Type Evidence Reference(s)
product RbsA protein nd nd
reactant rbsDACBKR_mRNA RNA nd nd
RbsC + RbsA + RbsB RbsA-RbsC-RbsB
Name: RbsC + RbsA + RbsB -> RbsA-RbsC-RbsB
Description: Reaction transforming RbsC, RbsA, RbsB into RbsA-RbsC-RbsB
Type: state transition
Pathway Components: RbsC + RbsA + RbsB -> RbsA-RbsC-RbsB
Components:
Function Name Type Evidence Reference(s)
reactant RbsA protein nd nd
product RbsA-RbsC-RbsB complex nd nd
reactant RbsB protein nd nd
reactant RbsC protein nd nd
RbsA-RbsC-RbsB beta-D-ribopyranose_Ext beta-D-ribopyranose
Name: beta-D-ribopyranose_Ext -> beta-D-ribopyranose
Description: Transport of beta-D-ribopyranose_Ext through a bacterial membrane, leading to the presence of beta-D-ribopyranose inside the cell.
Type: transport
Pathway Components: beta-D-ribopyranose_Ext - RbsA-RbsC-RbsB -> beta-D-ribopyranose
Components:
Function Name Type Evidence Reference(s)
catalyzer RbsA-RbsC-RbsB complex nd nd
product beta-D-ribopyranose simple_molecule nd nd
reactant beta-D-ribopyranose_Ext simple_molecule nd nd
rbsDACBKR_mRNA RbsC
Name: rbsDACBKR_mRNA -> RbsC
Description: Translation of RbsC
Type: translation
Pathway Components: rbsDACBKR_mRNA -> RbsC
Components:
Function Name Type Evidence Reference(s)
product RbsC protein nd nd
reactant rbsDACBKR_mRNA RNA nd nd
rbsDACBKR_mRNA RbsB
Name: rbsDACBKR_mRNA -> RbsB
Description: Translation of RbsB
Type: translation
Pathway Components: rbsDACBKR_mRNA -> RbsB
Components:
Function Name Type Evidence Reference(s)
product RbsB protein nd nd
reactant rbsDACBKR_mRNA RNA nd nd
rbsDACBKR_mRNA RbsK
Name: rbsDACBKR_mRNA -> RbsK
Description: Translation of RbsK
Type: translation
Pathway Components: rbsDACBKR_mRNA -> RbsK
Components:
Function Name Type Evidence Reference(s)
product RbsK protein nd nd
reactant rbsDACBKR_mRNA RNA nd nd
RbsK α D-ribose α-D-ribose 5-phosphate
Name: α D-ribose -> α-D-ribose 5-phosphate
Description: Reaction transforming α D-ribose into α-D-ribose 5-phosphate
Type: state transition
Pathway Components: α D-ribose - RbsK -> α-D-ribose 5-phosphate
Components:
Function Name Type Evidence Reference(s)
reactant α D-ribose simple_molecule nd nd
product α-D-ribose 5-phosphate simple_molecule nd nd
catalyzer RbsK protein nd nd
rbsDACBKR_mRNA RbsR
Name: rbsDACBKR_mRNA -> RbsR
Description: Translation of RbsR
Type: translation
Pathway Components: rbsDACBKR_mRNA -> RbsR
Components:
Function Name Type Evidence Reference(s)
product RbsR protein nd nd
reactant rbsDACBKR_mRNA RNA nd nd
add_mRNA Add
Name: add_mRNA -> Add
Description: Translation of Add
Type: translation
Pathway Components: add_mRNA -> Add
Components:
Function Name Type Evidence Reference(s)
product Add protein nd nd
reactant add_mRNA RNA nd nd
Add deoxyadenosine deoxyinosine + ammonium
Name: deoxyadenosine -> deoxyinosine + ammonium
Description: Reaction transforming deoxyadenosine into deoxyinosine, ammonium
Type: state transition
Pathway Components: deoxyadenosine - Add -> deoxyinosine + ammonium
Components:
Function Name Type Evidence Reference(s)
catalyzer Add protein nd nd
product ammonium simple_molecule nd nd
reactant deoxyadenosine simple_molecule nd nd
product deoxyinosine simple_molecule nd nd
Add adenosine ammonium + inosine
Name: adenosine -> ammonium + inosine
Description: Reaction transforming adenosine into ammonium, inosine
Type: state transition
Pathway Components: adenosine - Add -> ammonium + inosine
Components:
Function Name Type Evidence Reference(s)
catalyzer Add protein nd nd
reactant adenosine simple_molecule nd nd
product ammonium simple_molecule nd nd
product inosine simple_molecule nd nd
purHD_mRNA PurH
Name: purHD_mRNA -> PurH
Description: Translation of PurH
Type: translation
Pathway Components: purHD_mRNA -> PurH
Components:
Function Name Type Evidence Reference(s)
product PurH protein nd nd
reactant purHD_mRNA RNA nd nd
PurH 10-formyl-THF mono-L-glutamate + AICAR THF polyglutamate + FAICAR
Name: 10-formyl-THF mono-L-glutamate + AICAR -> THF polyglutamate + FAICAR
Description: Reaction transforming 10-formyl-THF mono-L-glutamate, AICAR into THF polyglutamate, FAICAR
Type: state transition
Pathway Components: 10-formyl-THF mono-L-glutamate + AICAR - PurH -> THF polyglutamate + FAICAR
Components:
Function Name Type Evidence Reference(s)
reactant 10-formyl-THF mono-L-glutamate simple_molecule nd nd
reactant AICAR simple_molecule nd nd
product FAICAR simple_molecule nd nd
catalyzer PurH protein nd nd
product THF polyglutamate simple_molecule nd nd
PurH 5'-IMP FAICAR
Name: 5'-IMP -> FAICAR
Description: Reaction transforming 5'-IMP into FAICAR
Type: state transition
Pathway Components: 5'-IMP - PurH -> FAICAR
Components:
Function Name Type Evidence Reference(s)
reactant 5'-IMP simple_molecule nd nd
product FAICAR simple_molecule nd nd
catalyzer PurH protein nd nd
purHD_mRNA PurD
Name: purHD_mRNA -> PurD
Description: Translation of PurD
Type: translation
Pathway Components: purHD_mRNA -> PurD
Components:
Function Name Type Evidence Reference(s)
product PurD protein nd nd
reactant purHD_mRNA RNA nd nd
5-phosphoribosylamine PurD 5-phosphoribosylamine + glycine 5'-p-ribosylglycinamide + phosphate
Name: 5-phosphoribosylamine + glycine -> 5'-p-ribosylglycinamide + phosphate
Description: Reaction transforming 5-phosphoribosylamine, glycine into 5'-p-ribosylglycinamide, phosphate
Type: state transition
Pathway Components: 5-phosphoribosylamine + glycine - PurD - 5-phosphoribosylamine -> 5'-p-ribosylglycinamide + phosphate
Components:
Function Name Type Evidence Reference(s)
product 5'-p-ribosylglycinamide simple_molecule nd nd
inhibitor 5-phosphoribosylamine simple_molecule nd nd
reactant 5-phosphoribosylamine simple_molecule nd nd
catalyzer PurD protein nd nd
reactant glycine simple_molecule nd nd
product phosphate simple_molecule nd nd
beta-D-ribofuranose α D-ribose
Name: beta-D-ribofuranose -> α D-ribose
Description: Transformation of beta-D-ribofuranose into α D-ribose by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: beta-D-ribofuranose / RXN-14904 / α D-ribose
Components:
Function Name Type Evidence Reference(s)
product α D-ribose simple_molecule nd nd
reactant beta-D-ribofuranose simple_molecule nd nd
5'-p-ribosylglycinamide AICAR
Name: 5'-p-ribosylglycinamide -> AICAR
Description: Transformation of 5'-p-ribosylglycinamide into AICAR by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: 5'-p-ribosylglycinamide / GARTRANSFORMYL2-RXN / FGAMSYN-RXN / AIRS-RXN / RXN0-742 / RXN0-743 / SAICARSYN-RXN / AICARSYN-RXN / AICAR
Components:
Function Name Type Evidence Reference(s)
reactant 5'-p-ribosylglycinamide simple_molecule nd nd
product AICAR simple_molecule nd nd



RegulonDB